Results 71 to 80 of about 3,939 (188)
Modulation of host cell pathways by Coxiella burnetii Dot/Icm effectors
mLife, Volume 4, Issue 6, Page 577-596, December 2025.Abstract Coxiella burnetii, the etiological agent of Q fever, is a significant intracellular bacterial pathogen. C. burnetii is a highly infectious pathogen that primarily targets pulmonary alveolar macrophages during natural infection. It can then disseminate to macrophages in other tissues and organs, leading to chronic infections. C.
Jingya Yuan +3 more
wiley +1 more source
Cytofluorymetryczna analiza wybranych markerów apoptozy Fas/FasL (CD95/CD95L) w tkance gruczołu tarczowego u młodocianych pacjentów z chorobą Gravesa-Basedowa oraz zapaleniem tarczycy typu Hashimoto [PDF]
Pediatric Endocrinology, Diabetes and Metabolism, 2006 Wprowadzenie: Apoptoza, to jedna z postaci programowanej śmierci komórek, nazwana także śmiercią fizjologiczną albo śmiercią samobójczą komórek – jest mechanizmem regulacyjnym, pozwalającym na usunięcie komórek wytworzonych w nadmiarze i ...
Artur Bossowski +9 more
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Pro- and anti-apoptotic CD95 signaling in T cells
Cell Communication and Signaling, 2011 The TNF receptor superfamily member CD95 (Fas, APO-1, TNFRSF6) is known as the prototypic death receptor in and outside the immune system. In fact, many mechanisms involved in apoptotic signaling cascades were solved by addressing consequences and ...
Janssen Ottmar, Paulsen Maren
doaj +1 more source
Reprimo (RPRM): A Tumor Suppressor That Induces Extrinsic Apoptosis via YAP Signaling
Cancer Science, Volume 116, Issue 12, Page 3266-3273, December 2025.Reprimo (encoded by RPRM) is a p53 target gene that acts as a tumor suppressor and is frequently silenced by promoter hypermethylation in various cancers. Although previously known to function intracellularly as a tumor suppressor, recent studies revealed that secreted Reprimo also induces apoptosis in neighboring cells through a novel p53‐Reprimo ...
Masahiro Takikawa, Rieko Ohki
wiley +1 more source
CD95L Inhibition Impacts Gemcitabine-Mediated Effects and Non-Apoptotic Signaling of TNF-α and TRAIL in Pancreatic Tumor Cells [PDF]
, 2021 Despite the potential apoptotic functions, the CD95/CD95L system can stimulate survival as well as pro-inflammatory signaling, particularly through the activation of NFκB. This holds true for the TNF/TNFR and the TRAIL/TRAILR systems.
Freya Goumas +9 more
core +1 more source
CD73 Expression by CD4 + T Cells Marks Early Effector Memory T Cells
Immunology, Volume 176, Issue 4, Page 454-467, December 2025.The role of CD73 in the development of naïve CD4+ T cells. Naïve CD4+ T cells, which are negative for CD25, CD44, and positive for CD62L, are depicted based on the expression of CD73. CD73− and CD73+ subpopulations among naïve CD4+ T cells bear distinct characteristics.
Luxia Chen +5 more
wiley +1 more source
Asunercept as an innovative therapeutic approach for recurrent glioblastoma and other malignancies
Cancer Management and Research, 2019 Andriy Krendyukov, Christian GieffersApogenix AG, Heidelberg, GermanyCorrespondence: Andriy KrendyukovApogenix AG, Im Neuenheimer Feld 584, Heidelberg 69120, GermanyEmail andriy.krendyukov@apogenix.comAbstract: Glioblastoma is the most common and ...
Krendyukov A, Gieffers C
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Nature Communications, 2016 Activation and biological function of B cells in cancer are still unclear. Here, the authors show that hepatocarcinoma cells drive the formation of semimature dendritic cells that in turn activate FcγRIIlow/−tumour B cells through the CD95L/CD95 axis ...
Fang-Zhu Ouyang +9 more
doaj +1 more source
Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism
Obesity Reviews, Volume 26, Issue 12, December 2025.ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso +5 more
wiley +1 more source
Reirradiation: Standards, challenges, and patient‐focused strategies across tumor types
CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 630-666, November/December 2025.Abstract Reirradiation (reRT), defined as administering a course of radiation therapy to a specific area previously irradiated, is an evolving treatment strategy for locoregionally recurrent cancer that offers significant potential and poses inherent challenges.
Arnaud Beddok +21 more
wiley +1 more source