Results 51 to 60 of about 3,939 (188)
eLife, 2017 Over 80% of multiple-tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death characterized by simultaneous activation of multiple cell death pathways preferentially killing transformed and cancer stem cells. We now show
William Putzbach +12 more
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iScience, 2021 Summary: CD95 expression is preserved in triple-negative breast cancers (TNBCs), and CD95 loss in these cells triggers the induction of a pro-inflammatory program, promoting the recruitment of cytotoxic NK cells impairing tumor growth.
Jean-Philippe Guégan +5 more
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Andrology, EarlyView.ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus +6 more
wiley +1 more source
Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway. [PDF]
PLoS Biology, 2019 [This corrects the article DOI: 10.1371/journal.pbio.1001090.].
Sébastien Tauzin +13 more
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From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
The Scientific World Journal, 2013 Up- and downregulation of eosinopoiesis control pulmonary eosinophilia in human asthma. In mice, eosinopoiesis is suppressed in vitro by prostaglandin E2 (PGE2) and in vivo by diethylcarbamazine, through a proapoptotic mechanism sequentially requiring ...
Bianca de Luca +9 more
doaj +1 more source
Redox Biology, 2015 Hepatocellular carcinoma develops in cirrhotic liver. The nitric oxide (NO) synthase type III (NOS-3) overexpression induces cell death in hepatoma cells.
Raúl González +10 more
doaj +1 more source
Resveratrol for Cancer Radio‐Sensitization: Ready for Prime Time or Future Perspective
Food Science &Nutrition, Volume 14, Issue 5, May 2026.Resveratrol exerts antioxidant and anti‐inflammatory effects by reducing reactive oxygen species and suppressing NF‐κB and JAK/STAT signaling pathways. It modulates metabolic signaling through AMPK‐dependent inhibition of mTOR, influencing cell survival and inflammatory responses.
Maryam Fallah +7 more
wiley +1 more source
Death Induced by CD95 or CD95 Ligand Elimination
Cell Reports, 2014 CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. We now show that elimination of CD95 or CD95L results in a form of cell death that is independent of caspase-8, RIPK1/MLKL, and p53, is not inhibited by Bcl-xL ...
Abbas Hadji +13 more
doaj +1 more source
BMC Immunology, 2023 Background Patients with Sjögren’s syndrome, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) are among the dysregulated proteins. Methods We studied Fas and FasL on IL-
Irena Lindrova +9 more
doaj +1 more source