Results 61 to 70 of about 3,939 (188)

Oxidative Stress‐Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Oxidative stress is a common occurrence in testicular cells of infertile men and is considered a significant cause of male reproductive dysfunction. The increase in reactive oxygen species (ROS) leads to impaired spermatogenesis by activating caspases and generating free radicals from mitochondria, resulting in DNA damage and cell death ...
Nafiseh Sanei‐Ataabadi, Fatemeh Aboutalebi, Kianoush Dormiani, Mohammad Hossein Nasr‐Esfahani   +3 more
wiley   +1 more source

Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion

eLife, 2016
Integrin activation is crucial for the regulation of leukocyte rolling, adhesion and trans-vessel migration during inflammation and occurs by engagement of myeloid cells through factors presented by inflamed vessels.
Liang Gao, Gülce Sila Gülcüler, Lieke Golbach, Helena Block, Alexander Zarbock, Ana Martin-Villalba   +5 more
doaj   +1 more source

Loss of Myonuclei and Transcriptional Activity During Diaphragm Atrophy in Critically Ill Patients

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Diaphragm weakness frequently develops in critically ill patients and is explained by a combination of atrophy and myofiber dysfunction. Myofibers are large syncytial cells maintained by a population of myonuclei, which provide gene transcripts to a finite fiber volume, termed the myonuclear domain.
Wout J. Claassen, Marloes van den Berg, Zhong Hua Shi, Rianne. J. Baelde, Sylvia Bogaards, Luuk Bonis, Heleen Hakkeling, Arezou Bamyani, Gerben J. Schaaf, Albertus Beishuizen, Chris Dickhoff, Reinier A. Boon, Leo Heunks, Tyler J. Kirby, Coen A. C. Ottenheijm   +14 more
wiley   +1 more source

CD95 ligand (CD95L) immunohistochemistry: a critical study on 12 antibodies [PDF]

Cell Death & Differentiation, 2001
In recent years, some studies on the expression of CD95(Fas/APO-1) ligand (CD95L) in tissues or cells raised concerns about the specificity of the antibodies used. We therefore tested 12 CD95L antibodies for their reliability in immunocyto/histochemistry by (i) staining CD95L-transfected and control CV-1/EBNA cells and (ii) comparing staining patterns ...
J, Sträter, H, Walczak, C, Hasel, I, Melzner, F, Leithäuser, P, Möller   +5 more
openaire   +2 more sources

Effect of reactive oxygen species generation in rabbit corneal epithelial cells on inflammatory and apoptotic signaling pathways in the presence of high osmotic pressure. [PDF]

PLoS ONE, 2013
It is generally accepted that high osmotic pressure (HOP) of lacrimal fluid is the core mechanism causing ocular inflammation and injury. However, the association between HOP and the regulation of cell inflammatory response and apoptotic pathways remains
Yihui Chen, Min Li, Bing Li, Weifang Wang, Anjuan Lin, Minjie Sheng   +5 more
doaj   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Rôles des caspases initiatrices et des sphingomyéline synthases dans l'apoptose induite par CD95L et TRAIL [PDF]

, 2011
La mort cellulaire par apoptose est un mécanisme effecteur de la réponse immunitaire anti-tumorale. La liaison de ligands, dont TRAIL et CD95L, produits par des cellules immunitaires, sur des récepteurs de mort (DR pour Death Receptor), exprimés par les ...
Lafont, Elodie
core  

Monocytes in Neonatal Bacterial Sepsis: Think Tank or Workhorse?

BioChem, 2022
Infection and sepsis remain among the leading causes of neonatal mortality. The susceptibility of newborns to infection can be attributed to their immature immune system.
Caitlin Doughty, Louise Oppermann, Niels-Ulrik Hartmann, Stephan Dreschers, Christian Gille, Thorsten Orlikowsky   +5 more
doaj   +1 more source

Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Autoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body’s own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and immune factors all play a part.
Hadiseh Farahani, Parviz Kokhaei, Ali Ganji, Ghasem Mosayebi, Ali Ghazavi, Masanori Murayama   +5 more
wiley   +1 more source

Depletion and suppression of human HLA-alloreactive T-cells by CD95L expressing cells

, 2011
In dieser Arbeit wurde die Depletion alloreaktiver T-Zellen mittels CD95L exprimierender Zellen mit dem Ziel einer möglichen Anwendung von Donor-Lymphozyten-Präparaten nach allogener Stammzelltransplantation (SCT) untersucht.
Jacobsen Eva-Maria (137679777)
core   +2 more sources