Results 81 to 90 of about 3,939 (188)

Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma

Advanced Healthcare Materials, Volume 14, Issue 29, November 14, 2025.
A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li, Jiahui Li, Hasan Al Faruque, Paul Shami, Birgit Knoechel, Jens Lohr, Douglas Sborov, Jiyuan Yang, Jindřich Kopeček   +8 more
wiley   +1 more source

Expression of CD95 and CD95L protein in RCECs.

, 2013
A: western blotting analysis showing the presence of CD95 and CD95L protein in RCECs. B, C: Results of statistical analysis of protein levels relative to GAPDH.
Yihui Chen (446576), Min Li (12799), Weifang Wang (421565), Anjuan Lin (446577), Bing Li (43671), Minjie Sheng (446578)   +5 more
core   +1 more source

Sjogren’s syndrome: apoptosis by anti-SSA and anti-SSB antibodies

Reumatismo, 2011
The pathogenesis of the Sjogren’s Syndrome (SjS) has not yet been completely defined. However, the cell-mediated immunity plays an important role and the apoptosis of the ductal and acinar epithelial cells is responsible of the glandular tissue damage ...
A. Scagliusi, S. D'Amore, M. D'Amore, P. Scagliusi   +3 more
doaj   +1 more source

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

Advancements in DNA‐Driven Precision Modulation of Cell Surface Receptor for Programmable Cellular Functions

Advanced Science, Volume 12, Issue 32, August 28, 2025.
DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan, Ming Cai, Yiyu Wang, Hong‐Hui Wang, Zhou Nie   +4 more
wiley   +1 more source

Topical imiquimod and in situ vulvar melanoma: A promising therapy?

International Journal of Gynecology &Obstetrics, Volume 170, Issue 2, Page 608-613, August 2025.
Abstract Objectives Vulvar melanoma is a rare type of cancer that affects mainly postmenopausal women. There are no established protocols for the treatment of vulvar melanoma. From data extrapolated from the literature on cutaneous melanoma, surgical excision remains the best option for the resectable disease.
Francesca Pepe, Flavia Silvestri, Eleonora Petra Preti, Anna Daniela Iacobone, Gianluigi Radici, Sabina Vaccari, Paola Queirolo, Giulio Tosti   +7 more
wiley   +1 more source

CD95L cell surface cleavage triggers a pro-metastatic signaling pathway in triple negative breast cancer. [PDF]

, 2013
International audienceTriple-negative breast cancers (TNBC) lacking estrogen and progesterone receptors and HER2 amplification have a relatively high risk of metastatic dissemination, but the mechanistic basis for this risk is not understood.
Goubard, Armelle, Campion, Loic, Vacher, Pierre, Jezequel, Pascal, Debure, Laure, Bessede, Alban, Castellano, Remy, Collette, Yves, Tauzin, Sebastien, Macgrogan, Gaetan, Ducret, Thomas, Malleter, Marine, Legembre, Patrick, Godey, Florence, Leveque, Jean, Campone, Mario   +15 more
core   +1 more source

Apoptosis in neuroblastomas induced by interferon-gamma involves the CD95/CD95L pathway

Background and Procedure. The CD95/ CD95 ligand (CD95L) system is a key regulator of apoptosis. To evaluate a possible role of the CD95/CD95L system in human neuroblastoma (NB) cells, we investigated the constitutive and interferon gamma (INF gamma ...
Bernassola, C.P.F., M., Melino, P.E., Pearson, Lovat, Redfern, G., F., A.D.J., Annicchiarico-Petruzzelli   +11 more
core   +5 more sources

Neutrophil-dependent tumor rejection and priming of tumoricidal CD8+ T cell response induced by dendritic cells overexpressing CD95L.

, 2008
Overexpression of CD95 (Fas/Apo-1) ligand (CD95L) has been shown to induce T cell tolerance but also, neutrophilic inflammation and rejection of allogeneic tissue.
Kris Thielemans, Frédéric Paulart, Thielemans, Kris M., Flamand, Véronique, Sofia Buonocore, Heirman, Carlo, Haddou, Najate Ouled, Fabrice Moore, Michel Goldman, Goldman, Michel, Najate Ouled Haddou, Véronique Flamand, Thielemans, Kris, Moore, Fabrice, Paulart, Frédéric, Florquin, Sandrine, Sandrine Florquin, Carlo Heirman, Buonocore, Sofia   +18 more
core   +1 more source

Cytotoxic activity of peripheral blood lymphocytes in children with infectious mononucleosis

Бюллетень сибирской медицины, 2009
Twenty children aged 3—6 years with Epstein—Barr-virus-induced infectious mononucleosis (IM) were examined. The present study is aimed at investigating the functional activity of cytotoxic lymphocytes in children with IM during clinical and hematological
N. R. Slepicheva, O. I. Urazova, V. V. Novitsky, A. P. Pomogayeva   +3 more
doaj   +1 more source