Results 111 to 120 of about 6,938 (195)
lHuman cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis [PDF]
, 2005 Effector-memory T cells expressing Fas (Apo-1/CD95) are switched to an apoptotic program by cross-linking with Fas-ligand (FasL). Consequently, tumors that express FasL can induce apoptosis of infiltrating Fas-positive T lymphocytes and subdue any ...
Biagi, E +8 more
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Scientific Reports, 2018 Naive T cells are known to express the modest level of TLR4 while it is known to go down during TCR activation. However, information towards the requirement of TLR4 signaling during TCR or mitogenic activation of naive wild-type T cells remains scanty ...
Subhransu Sekhar Sahoo +7 more
doaj +1 more source
Tolerance and autoimmunity: novel therapeutic approaches [PDF]
, 2009 La función primaria del sistema inmune es resguardar al individuo de los patógenos potencialmente dañinos que invaden el medio ambiente en el cual nos desarrollamos.
Carambia, Leandro +5 more
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Blocking of the B7-CD28 pathway increases the capacity of FasL+ (CD95L+) dendritic cells to kill alloactivated T cells [PDF]
, 1997 AW Thomson +22 more
core +1 more source
, 2018 Chronic pancreatitis is a progressive inflammation in pancreas results in fibrosis and irreversible damage lead to loss of exocrine and endocrine function. Mortality and complication rate is high. Appropriate management of chronic pancreatitis begin from
Abdullah, M. (Murdani) +2 more
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Zhongguo shiyan zhenduanxue, 2011 肿瘤不仅是增殖和分化异常的疾病,同时也是凋亡异常的疾病,肿瘤常表现出细胞增生亢进及凋亡减少。Fas/FasL系统是凋亡相关基因[1,2]。Fas,又名CD95或APO-1,属于肿瘤坏死因子受体（TN-FR）和神经生长因子受体（NGFR）家族。人Fas基因定位于第10号染色体长臂2区（10q24.1）,包含8个内含子和9个外显子。Fas配体（Fasl）,又称CD95L,
张妍, 张文颖, 周玲, 王莉
doaj
Evolutionary regulation of human Fas ligand (CD95L) by plasmin in solid cancer immunotherapy
Nature CommunicationsDespite sharing >98% genomic similarity, humans are more likely to develop cancers than our closest living ancestors, the nonhuman primates. Here, we unexpectedly discover that, unlike chimpanzee and other primates, a critical embryonic development ...
Brice E. N. Wamba +10 more
doaj +1 more source
Chemotherapy Sensitizes Colon Cancer Initiating Cells to Vc9Vd2 T Cell-Mediated Cytotoxicity [PDF]
, 2013 Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible for tumor maintenance and resistance to anti-cancer therapies, possibly allowing for tumor recapitulation once treatment stops.
CACCAMO, Nadia Rosalia +6 more
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Antitumor effect of allogenic fibroblasts engineered to express Fas ligand (FasL) [PDF]
, 1998 Fas ligand is a type II transmembrane protein which can induce apoptosis in Fas-expressing cells. Recent reports indicate that expression of FasL in transplanted cells may cause graft rejection and, on the other hand, tumor cells may lose their ...
Bilbao, R. (Roberto) +4 more
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CD95 Ligand (CD95L) in Normal Human Lymphoid Tissues [PDF]
The American Journal of Pathology, 1999 Jörn Sträter +6 more
openaire +1 more source