Results 131 to 140 of about 33,736 (233)

Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. [PDF]

, 1996
Viral oncoproteins that inactivate the retinoblastoma tumor suppressor protein (pRb) family both block skeletal muscle differentiation and promote cell cycle progression.
Jacks, T, Lassar, AB, Mulligan, GJ, Novitch, BG   +3 more
core  

Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]

, 1996
In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M., Félix, M. A., Guet, C. C., Leibler, S.   +3 more
core   +2 more sources

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

Animal Models and Experimental Medicine
Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer (CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing
Mohammad Yasin Zamanian, Niloofar Taheri, Montather F. Ramadan, Yasser Fakri Mustafa, Safa Alkhayyat, Klunko Nataliya Sergeevna, Hashem O. Alsaab, Ahmed Hjazi, Farnoosh Molavi Vasei, Siamak Daneshvar   +9 more
doaj   +1 more source

Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases [PDF]

, 2008
We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions and ...
Gil-Mi Ryu, Jong Hun Kim, Kyu-Won Kim, Kyung-Soo Oh, Pamela Song   +4 more
core   +1 more source

Mutations In RAD27 Define A Potential Link Between G₁ Cyclins And DNA Replication [PDF]

, 1995
The yeast Saccharomyces cerevisiae has three G1 cyclin (CLN) genes with overlapping functions. To analyze the functions of the various CLN genes, we examined mutations that result in lethality in conjunction with loss of cln1 and cln2.
Cross, Frederick R., , \u2778, Vallen, Elizabeth Ann   +1 more
core   +1 more source

Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression

Molecular Oncology
In advanced prostate cancer (PC), in particular after acquisition of resistance to androgen receptor (AR) signaling inhibitors (ARSI), upregulation of AR splice variants compromises endocrine therapy efficiency.
Jasper Van Goubergen, Miroslav Peřina, Florian Handle, Elisa Morales, Anika Kremer, Oliver Schmidt, Glen Kristiansen, Marcus V. Cronauer, Frédéric R. Santer   +8 more
doaj   +1 more source

cdc2 Protein Kinase: Interactions with Cyclins and sucl

Cold Spring Harbor Symposia on Quantitative Biology, 1991
P. Brambilla, B. Ducommun, G. Draetta
openaire   +1 more source

The mitotic functions of a fission yeast CK1 enzyme are regulated by Cdk1-dependent and auto-phosphorylation. [PDF]

J Biol Chem
Akizuki K, Cullati SN, Johnson AE, Chen JS, Willet AH, Gould KL.   +5 more
europepmc   +1 more source

Phylogenetic and structural analyses reveal Cdc2-like kinases (CLKs) as ancient regulators of thermosensitive splicing. [PDF]

J Biol Chem
Ogle RA, Netherton JK, Robinson BR, Heyd F, Baker MA.   +4 more
europepmc   +1 more source

Efficacy of Wee1 G2 Checkpoint Kinase and Mouse Double Minute 2 Homolog Inhibitors in Gastrointestinal Stromal Tumors Determined by p53 Status. [PDF]

Oncol Res
Chen CP, Tang YJ, Cai YY, Pan YR, Yeh CN, Huang WK, Lo CH, Hsiao YT, Shih HJ, Wu CE.   +9 more
europepmc   +1 more source