Results 191 to 200 of about 33,736 (233)
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Structure, function, and regulation of neuronal Cdc2-like protein kinase
Neurobiology of Aging, 1995We have identified and purified from bovine brain a novel protein kinase which catalyzes in vitro phosphorylation of neurofilament proteins NF-H and NF-M and tau proteins at sites implicating the enzyme in the regulation of neurocytoskeleton dynamics and in Alzheimer pathology.
Lew, J. +7 more
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Activation of the various cyclin/cdc2 protein kinases
Current Opinion in Cell Biology, 1993Recent research has led to the near culmination of the biochemical confirmation of the most basic genetic predictions about how p34cdc2 activity is controlled. The field is now moving from a biochemical dissection of the machinery to understanding how the system is regulated.
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Biology of the Cell, 1990
Summary—Among protein serine/threonine kinases, the CDC2 proteins are both well characterized as protein serine/threonine kinases and are functionally involved in the control of cell division. Protein serine/threonine kinase sequences were analysed using Fourier transform of the coded sequences. Characteristic code/frequency pairs were extracted from a
M A, Guerrucci, H, Soldano, R, Bellé
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Summary—Among protein serine/threonine kinases, the CDC2 proteins are both well characterized as protein serine/threonine kinases and are functionally involved in the control of cell division. Protein serine/threonine kinase sequences were analysed using Fourier transform of the coded sequences. Characteristic code/frequency pairs were extracted from a
M A, Guerrucci, H, Soldano, R, Bellé
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Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate
Nature, 1988cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation.
G, Draetta +5 more
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Reviews in Medical Virology, 2003
AbstractHerpesviruses encode protein kinases. A subset of these proteins, represented by HSV‐1 UL13, are conserved throughout all members of the Herpesviridae, and here, are designated CHPKs (conserved herpesvirus protein kinases). In addition to conserved gene products like CHPKs, herpesviruses encode genes specific to respective herpesviruses.
Yasushi, Kawaguchi, Kentaro, Kato
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AbstractHerpesviruses encode protein kinases. A subset of these proteins, represented by HSV‐1 UL13, are conserved throughout all members of the Herpesviridae, and here, are designated CHPKs (conserved herpesvirus protein kinases). In addition to conserved gene products like CHPKs, herpesviruses encode genes specific to respective herpesviruses.
Yasushi, Kawaguchi, Kentaro, Kato
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Regulation of the Mitotic CDC2 Protein Kinase
1993The eukaryotic cell cycle is characterized by two major events, DNA replication (S phase) and mitosis (M phase); these are separated by two so-called “gap”-phases, G1 (prior to S phase) and G2 (prior to M phase). According to the current paradigm of the cell cycle as a “cdc2 cycle”, both DNA replication and mitosis are driven by serine-threonine ...
E. A. Nigg, W. Krek, P. Gallant
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cdc2 protein kinase: structure-function relationships.
Ciba Foundation symposium, 1993Activation of the cdc2 kinase in the cell cycle occurs upon binding to a regulatory subunit called cyclin. Cyclin A associates with both Cdc2 and its homologue Cdk2. The two complexes appear in S phase but cyclin A/Cdk2 is activated earlier than cyclin A/Cdc2. Several regions in Cdc2 are involved in binding cyclins A and B.
M J, Marcote, M, Pagano, G, Draetta
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PISSLRE, a human novel CDC2-related protein kinase.
Oncogene, 1994The cell division cycle have been shown to be regulated by a closely-related family of protein kinases named CDKs (by cyclin-dependent kinases). Using a PCR-based cloning technique, we have isolated cDNAs encoding a human CDC2-related protein kinase. The full-length cDNA accommodates an open reading frame that does not contain any ATG initiation codon ...
GRANA X +4 more
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cdc2-related protein kinases and cell cycle control in trypanosomatids
Parasitology Today, 1994The molecular mechanisms that control the cell cycle have been studied extensively in yeast and higher eukaryotes. Investigations have centred on the cyclin-dependent kinase family of serine/threonine protein kinases, the best characterized of which is cdc2, a key regulatory element in the control of mitosis.
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Investigation of CDC2-independent mitotic protein kinases
2009Mitosis is a highly coordinated event which ensures the equal segregation of the cytoplasmic and genetic material into two daughter cells. A key regulatory process in ensuring the temporal fidelity of mitosis involves reversible protein phosphorylation mediated by protein kinases and phosphatases.
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