Results 111 to 120 of about 6,022 (190)
A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Chinese patients [PDF]
, 2011 Background Peutz-Jeghers syndrome (PJS) is caused by mutations in the tumor suppressor gene, STK11, and is characterized by gastrointestinal hamartomas, melanin spots on the lips, and an increased risk of developing cancer.
Zhiqing Wang +5 more
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Frontiers in Molecular Neuroscience, 2019 Opioid activation of the mu opioid receptor (MOR) promotes signaling cascades that evoke both analgesic responses to pain and side effects like addiction and dependence.
Wei Lei +6 more
doaj +1 more source
Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles [PDF]
, 2016 B-Raf represents a critical physiological regulator of the Ras/RAF/MEK/ERK-pathway and a pharmacological target of growing clinical relevance, in particular in oncology.
Baumeister, Ralf +17 more
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A molecular mechanism of chaperone–client recognition [PDF]
, 2016 Molecular chaperones are essential in aiding client proteins to fold into their native structure and in maintaining cellular protein homeostasis. However, mechanistic aspects of chaperone function are still not well understood at the atomic level. We use
He, Lichun +3 more
core +2 more sources
Identification and dynamics of two classes of Aurora-like kinases in Arabidopsis and other plants [PDF]
, 2005 Aurora-like kinases play key roles in chromosome segregation and cytokinesis in yeast, plant, and animal systems. Here, we characterize three Arabidopsis thaliana protein kinases, designated AtAurora1, AtAurora2, and AtAurora3, which share high amino ...
Demidov, Dmitri +4 more
core +1 more source
PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1
Parkinson's Disease, 2011 Recent publications suggest that the Parkinson's disease- (PD-) related PINK1/Parkin pathway promotes elimination of dysfunctional mitochondria by autophagy.
Aleksandar Rakovic +6 more
doaj +1 more source
Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance. [PDF]
, 2019 A mammalian cell houses two genomes located separately in the nucleus and mitochondria. During evolution, communications and adaptations between these two genomes occur extensively to achieve and sustain homeostasis for cellular functions and ...
Jiang, Nian +3 more
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Computational analysis of the LRRK2 interactome. [PDF]
, 2015 LRRK2 was identified in 2004 as the causative protein product of the Parkinson's disease locus designated PARK8. In the decade since then, genetic studies have revealed at least 6 dominant mutations in LRRK2 linked to Parkinson's disease, alongside one ...
Denny, P +3 more
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Scientific Reports, 2017 Two missense mutations of the DYRK1B gene have recently been found to co-segregate with a rare autosomal-dominant form of metabolic syndrome. This gene encodes a member of the DYRK family of protein kinases, which depend on tyrosine autophosphorylation ...
Samira Abu Jhaisha +6 more
doaj +1 more source
Quantitative proteomic study of cell cycle of Prorocentrum donghaiense during the blooming period [PDF]
, 2016 东海原甲藻（Prorocentrumdonghaiense）是中国近海主要有害藻华种，几乎每年都会引发大规模的有害藻华，对海洋生态系统、海洋生物资源和水产养殖造成了严重威胁，并且影响公众健康。尽管目前对东海原甲藻藻华形成的海洋学和生态学机制开展了大量研究，但对现场藻华形成过程中东海原甲藻细胞生长调控的分子机制知之甚少。 本论文以现场东海原甲藻藻华为研究对象，运用基于质谱的定量蛋白质组学技术—iTRAQ（isobarictagsforrelativeandabsolutequantitation）技术 ...
刘九玲
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