Results 151 to 160 of about 3,736 (194)

The role of the FKBP51-Hsp90 complex in Alzheimer's disease: An emerging new drug target. [PDF]

Cell Stress Chaperones
Jeanne X, Török Z, Vigh L, Prodromou C.   +3 more
europepmc   +1 more source

CDK4/6 Inhibitors for Breast Cancer Therapy-A Review of Clinical Trials, Structural and Computational Approaches. [PDF]

Pharmaceuticals (Basel)
Avdičević A, Lešnik S, Bren U, Čavka L.   +3 more
europepmc   +1 more source

Targeting HSP90 in cancer: advances in the development of inhibitors, mechanisms of action, and therapeutic applications. [PDF]

Mol Cancer
Wang X, Ni R, Wang X, Li X.
europepmc   +1 more source

Repurposing Ilaprazole as a PP5 TPR Domain Binder with Modulatory Effects on MAPK Signaling. [PDF]

ACS Med Chem Lett
He Y, Gu J, Hua L, Zhai D, Huang Q, Pei J, You Q, Zhang Q, Wang L.   +8 more
europepmc   +1 more source

Identification of drug candidates against glioblastoma with machine learning and high-throughput screening of heterogeneous cellular models.

Digit Discov
Smer-Barreto V, Elliott RJR, Dawson JC, Lorente-Macías Á, Furqan M, Unciti-Broceta A, Oyarzún DA, Carragher NO.   +7 more
europepmc   +1 more source

Computational investigation of interactions between Cdc37 and celastrol

Molecular Simulation, 2013
Celastrol is a novel inhibitor of the human protein complex Hsp90Cdc37. It was found that the N-terminal domain of Cdc37 (Cdc37_N) was the molecular target for celastrol binding through covalent bonding.
Zhanli Wang, Yao-Kai Duan, Liangren Zhang   +2 more
exaly   +3 more sources

Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

Oncogene, 2013
The HSP90 molecular chaperone plays a key role in the maturation, stability and activation of its clients, including many oncogenic proteins. Kinases are a substantial and important subset of clients requiring the key cochaperone CDC37.
emmanuel de Billy, Laurence Pearl, Chrisostomos Prodromou   +2 more
exaly   +2 more sources

Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia [PDF]

Oncogene, 2000
The Cdc37 gene encodes a 50 kDa protein which targets intrinsically unstable oncoprotein kinases such as Cdk4, Raf-1, and src to the molecular chaperone Hsp90. This activity is thought to play an important role in the establishment of signaling pathways controlling cell proliferation.
Milton Finegold, Jeffrey W. Harper, Timothy C Thompson   +2 more
exaly   +3 more sources

MZF1 and SCAND1 Reciprocally Regulate CDC37 Gene Expression in Prostate Cancer [PDF]

Cancers, 2019
Cell division control 37 (CDC37) increases the stability of heat shock protein 90 (HSP90) client proteins and is thus essential for numerous intracellular oncogenic signaling pathways, playing a key role in prostate oncogenesis.
Stuart K Calderwood, Benjamin J Lang, Takanori Eguchi   +2 more
exaly   +3 more sources