Results 161 to 170 of about 6,074 (204)

Predictive value of CDC37 gene expression for targeted therapy in metastatic colorectal cancer. [PDF]

open access: yesEur J Cancer
Arai H   +31 more
europepmc   +1 more source

Prodrug-inspired adenosine triphosphate-activatable celastrol-Fe(III) chelate for cancer therapy. [PDF]

open access: yesSci Adv
Li H   +15 more
europepmc   +1 more source

Protective effect of CK2 against endoplasmic reticulum stress in pancreatic β cells. [PDF]

open access: yesDiabetol Int
Takai T   +6 more
europepmc   +1 more source

Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators

Bioorganic and Medicinal Chemistry, 2017
Targeting Hsp90-Cdc37 protein-protein interaction (PPI) is becoming an alternative approach for future anti-cancer drug development. We previously reported the discovery of an eleven-residue peptide (Pep-1) with micromolar activity for the disruption of Hsp90-Cdc37 PPI.
Lei  Wang   +2 more
exaly   +3 more sources

Computational investigation of interactions between Cdc37 and celastrol

Molecular Simulation, 2013
Celastrol is a novel inhibitor of the human protein complex Hsp90–Cdc37. It was found that the N-terminal domain of Cdc37 (Cdc37_N) was the molecular target for celastrol binding through covalent bonding. To get insight into the binding mode of celastrol in the active site of Cdc37, herein, the homology models of Cdc37_N and N-terminal/middle domain of
Yaokai Duan   +2 more
exaly   +2 more sources

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