Results 81 to 90 of about 6,022 (190)

Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90

Scientific Reports, 2021
The molecular chaperones Hsc70 and Hsp90 are required for proteostasis control and specific folding of client proteins in eukaryotic and prokaryotic organisms.
Lukas Schmauder, Eva Absmeier, Alexander Bepperling, Katalin Barkovits, Katrin Marcus, Klaus Richter   +5 more
doaj   +1 more source

Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms

Small Science, Volume 5, Issue 11, November 2025.
This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn, Yeram Lee, Gi‐Hoon Nam, Jae Bem You, Eun Jung Lee   +4 more
wiley   +1 more source

A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90a [PDF]

, 2011
Hsp90α's vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and cell lines validates it as a therapeutic target for glioma.
Adi Mehta, Altieri, Amal Shervington, Bagatell, Basso, Bisht, Boado, Brader, Braga-Basaria, Burger, Chang, Chatterjee, Chinmay Munje, Chiosis, Clarke, Cohen-Saidon, Cruickshanks, Duerfeldt, Elbashir, Eustace, Gaspar, Gazitt, Goetz, Graner, Han, Isaacs, Jane, Kamal, Kamal, Karkoulis, Koren, Kumar, Lang, Lanneau, Leroy Shervington, Li, Luo, McAnuff, McCollum, Padmini, Porter, Pu, Pu, Sauvageot, Schiffelers, Shervington, Shim, Siegelin, Solit, Sreedhar, Stommel, Walsh, Whitesell, Yang, Yen, Yu   +55 more
core   +2 more sources

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments

The FEBS Journal, Volume 292, Issue 22, Page 5899-5920, November 2025.
Gasdermins (GSDMs) are pore‐forming proteins best known for driving pyroptosis through plasma membrane (PM) permeabilization. Beyond triggering inflammatory cell death, GSDMs can also associate with organelle membranes, including mitochondria, lysosomes, ER, and nucleus, where they modulate membrane integrity and cellular signaling.
Eleonora Margheritis, Nadine Gehle, Katia Cosentino   +2 more
wiley   +1 more source

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression

eLife, 2021
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) normally signals to necroptosis by phosphorylating MLKL. We report here that when the cellular RIPK3 chaperone Hsp90/CDC37 level is low, RIPK3 also signals to apoptosis.
Dianrong Li, Jie Chen, Jia Guo, Lin Li, Gaihong Cai, She Chen, Jia Huang, Hui Yang, Yinhua Zhuang, Fengchao Wang, Xiaodong Wang   +10 more
doaj   +1 more source

The Human Cdc37·Hsp90 Complex Studied by Heteronuclear NMR Spectroscopy [PDF]

Journal of Biological Chemistry, 2009
The cell division cycle protein 37 (Cdc37) and the 90-kDa heat shock protein (Hsp90) are molecular chaperones, which are crucial elements in the protein signaling pathway. The largest class of client proteins for Cdc37 and Hsp90 are protein kinases. The catalytic domains of these kinases are stabilized by Cdc37, and their proper folding and functioning
Sreeramulu, Sridhar, Jonker, Hendrik R. A., Langer, Thomas, Richter, Christian, Lancaster, C. Roy D., Schwalbe, Harald   +5 more
openaire   +4 more sources

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, Volume 45, Issue 5, Page 1452-1465, September 2025.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90

Molecular Cancer, 2011
Background Multiple myeloma (MM) is a B-cell malignancy that is largely incurable and is characterized by the accumulation of malignant plasma cells in the bone marrow.
Xu Yuan-Ji, Du Zhi-Yan, Zhang Xu-Hui, Zhu Hai-Yan, Ma Jian, Zhao Ming, Yu Xiao-Dan   +6 more
doaj   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, Volume 5, Issue 4, August 2025.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges

Cancer Science, Volume 116, Issue 7, Page 1795-1806, July 2025.
Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li, Bing Wang, Lisha Ye, Guohua Wang   +3 more
wiley   +1 more source