Results 131 to 140 of about 86,770 (308)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Novel role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in adhesion and migration of 32D myeloid progenitor cells [PDF]

, 2012
Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic ...
Aschenbrenner, Frank, Bug, Gesine, Henschler, Reinhard, Hofmann, Wolf-Karsten, Kampfmann, Manuela, Komor, Martina, Ruthardt, Martin, Rüster, Brigitte Inge, Schwarz, Kerstin   +8 more
core   +1 more source

A hot-spot mutation in CDC42 (p.Tyr64Cys) and novel phenotypes in the third patient with Takenouchi-Kosaki syndrome

Journal of Human Genetics, 2018
Takenouchi-Kosaki syndrome (TKS) is a congenital malformation syndrome characterized by severe developmental delay, macrothrombocytopenia, camptodactyly, sensorineural hearing loss, and dysmorphic facial features.
Midori Motokawa, Satoshi Watanabe, A. Nakatomi, T. Kondoh, Tadashi Matsumoto, Kanako Morifuji, Hirotake Sawada, Toyoki Nishimura, H. Nunoi, K. Yoshiura, H. Moriuchi, S. Dateki   +11 more
semanticscholar   +1 more source

CDC42—a promising target of glioma treatment related to Treg cell proliferation [PDF]

, 2023
Tao Jiang, Xianwei Wang, Jiaming Huang, Dong Chen   +3 more
openalex   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking.

PLoS Biology, 2015
The small Rho-family GTPase Cdc42 is critical for cell polarization and polarizes spontaneously in absence of upstream spatial cues. Spontaneous polarization is thought to require dynamic Cdc42 recycling through Guanine nucleotide Dissociation Inhibitor (
Felipe O Bendezú, Vincent Vincenzetti, Dimitrios Vavylonis, Romain Wyss, Horst Vogel, Sophie G Martin   +5 more
doaj   +1 more source

miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients

British Journal of Cancer, 2017
Background:The lethality and poor outcome of high-grade gliomas result from the tumour relentless invasion. miR-29a/b/c downexpressions contribute to several human tumourigenesis.
C. Shi, Linlin Ren, Cuiyun Sun, Lin Yu, X. Bian, Xuexia Zhou, Yanjun Wen, D. Hua, Shujun Zhao, W. Luo, Run Wang, Chun Rao, Qian Wang, Shizhu Yu   +13 more
semanticscholar   +1 more source

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Cdc42 Promotes ADSC-Derived IPC Induction, Proliferation, And Insulin Secretion Via Wnt/β-Catenin Signaling

Diabetes, Metabolic Syndrome and Obesity, 2019
Xing-Hua Xiao,* Qi-Yuan Huang,* Xian-Ling Qian,* Jing Duan, Xue-Qiao Jiao, Long-Yuan Wu, Qing-Yun Huang, Jun Li, Xing-Ning Lai, Yu-Bo Shi, Li-Xia Xiong Department of Pathophysiology, Medical College, Nanchang University, Nanchang 330006, People’s ...
Xiao XH, Huang QY, Qian XL, Duan J, Jiao XQ, Wu LY, Huang QY, Li J, Lai XN, Shi YB, Xiong LX   +10 more
doaj  

Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration

JCI Insight, 2020
The regulatory mechanisms enabling the intestinal epithelium to maintain a high degree of regenerative capacity during mucosal injury remain unclear. Ex vivo survival and clonogenicity of intestinal stem cells (ISCs) strictly required growth response ...
Xiao Zhang, Sheila Bandyopadhyay, Leandro Pires Araujo, Kevin Tong, Juan Flores, Daniel Laubitz, Yanlin Zhao, George Yap, Jingren Wang, Qingze Zou, Ronaldo Ferraris, Lanjing Zhang, Wenwei Hu, Edward M. Bonder, Pawel R. Kiela, Robert Coffey, Michael P. Verzi, Ivaylo I. Ivanov, Nan Gao   +18 more
doaj   +1 more source