Results 141 to 150 of about 75,568 (261)

PACAP induces FSHβ gene expression via EPAC. [PDF]

, 2019
Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of their levels, primarily by GnRH, is critical for reproductive function.
Coss, Djurdjica, Yeh, Debra M
core  

miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling

International Journal of Endocrinology, 2019
Background. Diabetes is a progressive metabolic disease characterized by hyperglycemia. Functional impairment of islet β cells can occur to varying degrees.
Jing Duan, Xian-Ling Qian, Jun Li, Xing-Hua Xiao, Xiang-Tong Lu, Lin-Chen Lv, Qing-Yun Huang, Wen Ding, Hong-Yan Zhang, Li-Xia Xiong   +9 more
doaj   +1 more source

Mutation in CDC42 Gene Set as a Response Biomarker for Immune Checkpoint Inhibitor Therapy

Cancer Medicine
Background Immune checkpoint inhibitors (ICIs) have achieved great success; however, a subset of patients exhibits no response. Consequently, there is a critical need for reliable predictive biomarkers.
Kun Wang, Yingying Zhang, Zhaoming Su, Bei Wang, Yuanyang Zhou, Xiaochu Tong, Chengying Xie, Xiaomin Luo, Sulin Zhang, Mingyue Zheng   +9 more
doaj   +1 more source

Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation [PDF]

Epithelial cells develop morphologically characteristic apical domains that are bordered by tight junctions, the apical–lateral border. Cdc42 and its effector complex Par6–atypical protein kinase c (aPKC) regulate multiple steps during epithelial ...
Balda, M.S., Elbediwy, A., Harris, J., Keep, Nicholas H., Matter, K., Munro, P.M.G., Terry, S.J., Zihni, C.   +7 more
core   +1 more source

MP098PODOPLANIN OVEREXPRESSION IN RAT PODOCYTES INDUCES A MORPHOLOGICAL CHANGE SIMILAR TO FLATTENING OF FOOT PROCESSES VIA REGULATING RAC1 AND CDC42 ACTIVITY [PDF]

, 2016
Hitonari Nosaka, Sigurd Krieger, Nobuharu Fujiwara, Dai Oono, Shunya Uchida, Dontscho Kerjaschki, Kenichiro Kojima   +6 more
openalex   +1 more source

Overexpression of RhoA, Rac1, and Cdc42 GTPases Is Associated with Progression in Testicular Cancer [PDF]

, 2004
Takao Kamai, Tomonori Yamanishi, Hiromichi Shirataki, Kentaro Takagi, Hidekazu Asami, Yuji Ito, Ken‐Ichiro Yoshida   +6 more
openalex   +1 more source

Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis [PDF]

, 2007
During animal cell chemotaxis, signalling at the plasma membrane induces actin polymerisation to drive forward cell movement. Since the cellular pool of actin is limited, efficient protrusion formation also requires the coordinated disassembly of pre ...
Baum, B, Jovceva, E, Larsen, MR, Timms, JF, Waterfield, MD   +4 more
core  

MICAL‐L2 potentiates Cdc42‐dependent EGFR stability and promotes gastric cancer cell migration [PDF]

, 2019
Pengxiang Min, Shuo Zhao, Lei Liu, Yujie Zhang, Yadong Ma, Xuyang Zhao, Yueyuan Wang, Yixuan Song, Chenchen Zhu, Haonan Jiang, Luo Gu, Jun Du   +11 more
openalex   +1 more source

Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

Genes and Diseases
Developmental defects of enamel are common due to genetic and environmental factors before and after birth. Cdc42, a Rho family small GTPase, regulates prenatal tooth development in mice.
Jinxuan Zheng, Rongcheng Yu, Yiqi Tang, Sihui Su, Sainan Wang, Chenxi Liao, Xuecong Li, Jiabin Liao, Dongsheng Yu, Tingting Ai, Wei Zhao, Vicky Yau, Chufeng Liu, Liping Wu, Yang Cao   +14 more
doaj   +1 more source

Paradoxical signaling regulates structural plasticity in dendritic spines

, 2016
Transient spine enlargement (3-5 min timescale) is an important event associated with the structural plasticity of dendritic spines. Many of the molecular mechanisms associated with transient spine enlargement have been identified experimentally.
Khan, Shahid M., Levy, Michael G., Oster, George, Rangamani, Padmini   +3 more
core   +1 more source