Results 161 to 170 of about 81,267 (316)
Nature Communications, 2015 Phagocytosis is responsible for the elimination of particles of widely disparate sizes, from large fungi or effete cells to small bacteria. Though superficially similar, the molecular mechanisms involved differ: engulfment of large targets requires ...
Daniel Schlam +6 more
semanticscholar +1 more source
Opposing Expressions of Nidogen-1 and Cdc42 Genes in the Development of Liver Cirrhosis in Patients with Non-Alcoholic Fatty Liver Disease [PDF]
پزشکی بالینی ابن سیناBackground and Objective: The roles of Nidogen-1 and Cdc42 genes as significant factors in the metabolism of the extracellular matrix have been demonstrated in the fibrosis of various tissues. This study investigates the gene expressions of Nidogen-1 and
Zahra Ali +2 more
doaj
Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization [PDF]
, 2002 The Nf2 tumor suppressor gene product merlin is related to the membrane-cytoskeleton linker proteins of the band 4.1 superfamily, including ezrin, radixin, and moesin (ERMs). Merlin is regulated by phosphorylation in a Rac/cdc42-dependent fashion.
Eckman, Matthew S. +3 more
core +1 more source
The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion. [PDF]
, 2014 Cell polarization relies on small GTPases, such as Cdc42, which can break symmetry through self-organizing principles, and landmarks that define the axis of polarity.
Gallo Castro, D. +2 more
core +2 more sources
Locally excitable Cdc42 signals steer cells during chemotaxis
Nature Cell Biology, 2015 Neutrophils and other amoeboid cells chemotax by steering their front ends towards chemoattractant. Although Ras, Rac, Cdc42 and RhoA small GTPases all regulate chemotaxis, it has been unclear how they spatiotemporally control polarization and steering ...
Heebum Yang, Sean R. Collins, T. Meyer
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of proposed relationship between hyperglycaemia, gestational diabetes mellitus (GDM), active BCR‐related (ABR), RhoA and actin organization of feto‐placental arterial endothelial cells (fpEC). Hyperglycaemia upregulates ABR, which in turn increases RhoA activation.
Silvija Tokic +9 more
wiley +1 more source
European Journal of Cell Biology, 2022 Metastasis remains the main challenge to overcome for treating ovarian cancers. In this study, we investigate the potential role of the Cdc42 GAP StarD13 in the modulation of cell motility, invasion in ovarian cancer cells.
Sandra Abdellatef +9 more
doaj
The Journal of Physiology, EarlyView.Abstract figure legend During development, Intersectin‐1 (Itsn1) translocates near voltage‐gated calcium channels (VGCCs) to enhance Ca2+‐dependent replenishment of readily releasable synaptic vesicles (SVs). In the presynaptic terminal, SVs undergo a cycle involving formation (step 1), docking (step 2), exocytosis (step 3), endocytosis (step 4) and ...
Yi‐Mei Yang +13 more
wiley +1 more source
Molecular Biology of the Cell, 2017 Using FRET-based biosensors, we show that sphingosine-1-phosphate promotes endothelial integrity through S1PR1-Gαi-Rac1 and S1PR1-Gαi-Cdc42 pathways, in addition to activating a barrier disrupting S1PR2-Gα12/13-RhoA pathway.
N. R. Reinhard +7 more
semanticscholar +1 more source
PICK1 links AMPA receptor stimulation to Cdc42
Neuroscience Letters, 2015 Rho-family GTPases control numerous cell biological processes via effects on actin dynamics, such as cell migration, cell adhesion, morphogenesis and vesicle traffic. In neurons, they are involved in dendritic spine morphogenesis and other aspects of neuronal morphology via regulation of the actin cytoskeleton.
Rocca, Dan, Hanley, Jonathan
openaire +4 more sources