Results 191 to 200 of about 81,267 (316)

EGF‐Induced Macropinocytosis Promotes NAV1‐Dependent Internalization of Occludin in Keratinocytes

The FASEB Journal, Volume 39, Issue 8, 30 April 2025.
This graphical abstract illustrates how epidermal growth factor (EGF) stimulates macropinocytosis in keratinocytes, leading to the internalization of occludin, a key tight junction protein. NAV1 is identified as a critical mediator of this process, modulating macropinocytosis via the Rho family of GTPases.
Haruka Taira, Lixin Li, Asumi Koyama, Rino Toyoshima, Toyoki Yamamoto, Yukiko Ito, Eiki Sugimoto, Yuka Mizuno, Kentaro Awaji, Shinichi Sato, Sayaka Shibata   +10 more
wiley   +1 more source

Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

Genes and Diseases
CDC42 controls intestinal epithelial (IEC) stem cell (IESC) division. How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear. We utilized models of inflammatory bowel diseases (IBD), colorectal cancer, aging, and IESC injury to ...
Dongsheng Zhang, Wenjuan Tang, Haitao Niu, William Tse, Hai-Bin Ruan, Helmut Dolznig, Thomas Knösel, Friedrich Karl-Heinz, Madeleine Themanns, Jiang Wang, Mingquan Song, Lee Denson, Lukas Kenner, Richard Moriggl, Yi Zheng, Xiaonan Han   +15 more
doaj  

Analysis of the Mechanisms of Action of the Saccharomyces cerevisiae Dominant Lethal cdc42 G12V and Dominant Negative cdc42 D118A Mutations [PDF]

, 1998
Cynthia R. Davis, Tamara J. Richman, Steven Deliduka, Jeffrey O. Blaisdell, Cheryl Collins, Douglas I. Johnson   +5 more
openalex   +1 more source

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes [PDF]

, 1997
Dianne Cox, Peter Chang, Qing Zhang, Pabbathi G. Reddy, Gary Bokoch, Steven M. Greenberg   +5 more
openalex   +1 more source

The Myotonic Dystrophy Kinase-related Cdc42-binding Kinase Is Involved in the Regulation of Neurite Outgrowth in PC12 Cells [PDF]

, 1999
Xiangqun Chen, Ivan Tan, Thomas Leung, Louis Lim   +3 more
openalex   +1 more source

STIFFNESS OF 3D COLLAGEN MATRICES REGULATES CDC42 ACTIVITY OF ENDOTHELIAL COLONY FORMING CELLS DURING EARLY VACUOLE [PDF]

, 2012
poster abstractRecent preclinical reports have provided evidence that endothelial colony forming cells (ECFCs), a subset of endothelial progenitor cells, significantly improve vessel formation, largely due to their robust vasculogenic potential. While it
Kim, Seung Joon, Na, Sungsoo, Voytik-Harbin, Sherry, Yoder, Mervin   +3 more
core  

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

Cell, 1995
C. Nobes, A. Hall
semanticscholar   +1 more source

Cdc42 and Rac1 Regulate the Interaction of IQGAP1 with β-Catenin [PDF]

, 1999
Masaki Fukata, Shinya Kuroda, Masato Nakagawa, Aie Kawajiri, Naohiro Itoh, Ikuo Shoji, Yoshiharu Matsuura, Shin Yonehara, Hajime Fujisawa, Akira Kikuchi, Kozo Kaibuchi   +10 more
openalex   +1 more source

Gα13 Stimulates Na+-H+ Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways [PDF]

, 1996
Rebecca Hooley, Chun-Yuan Yu, Marc Symons, Diane L. Barber   +3 more
openalex   +1 more source

Matrix Adhesion Polarizes Heart Progenitor Induction In The Invertebrate Chordate Ciona Intestinalis [PDF]

, 2013
Cell-matrix adhesion strongly influences developmental signaling. Resulting impacts on cell migration and tissue morphogenesis are well characterized. However, the in vivo impact of adhesion on fate induction remains ambiguous.
Cooley, J., Cota, C. D., Davidson, Bradley Justin, , \u2791, Islam, A., Norton, J.   +4 more
core   +1 more source