Results 31 to 40 of about 86,770 (308)

A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function

Journal of Experimental Medicine, 2019
Lam et al. characterize a novel hematological/autoinflammatory disorder due to a de novo recurrent missense mutation of CDC42. The authors use in silico, in vitro, and in vivo analyses to correlate the molecular mechanisms altering CDC42 function to the ...
Michael T. Lam, Simona Coppola, Oliver H. F. Krumbach, G. Prencipe, A. Insalaco, C. Cifaldi, I. Brigida, Erika Zara, S. Scala, S. Di Cesare, S. Martinelli, Martina Di Rocco, A. Pascarella, M. Niceta, F. Pantaleoni, A. Ciolfi, P. Netter, Alexandre F. Carisey, Michael Diehl, M. Akbarzadeh, F. Conti, P. Merli, A. Pastore, Stefano Levi Mortera, S. Camerini, L. Fariña, Marcel Buchholzer, L. Pannone, Tram N. Cao, Z. Coban-Akdemir, S. Jhangiani, D. Muzny, R. Gibbs, L. Basso-Ricci, M. Chiriacò, R. Dvorsky, L. Putignani, R. Carsetti, P. Janning, A. Stray-Pedersen, H. C. Erichsen, A. Horne, Y. Bryceson, Lamberto Torralba-Raga, K. Ramme, V. Rosti, C. Bracaglia, V. Messia, P. Palma, A. Finocchi, F. Locatelli, Ivan K. Chinn, J. Lupski, E. Mace, C. Cancrini, A. Aiuti, M. Ahmadian, J. Orange, F. De Benedetti, M. Tartaglia   +59 more
semanticscholar   +1 more source

Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3β

Journal of Integrative Neuroscience, 2022
Background: Progressive axon degeneration is a common pathological feature of neurodegenerative diseases. Cdc42 is a member of the Rho GTPase family that participates in axonogenesis.
Yu-Ting Li, Fang-Zheng Chen, Wei Chen, Hui-Ming Zhu, Yu Chen, Zhen-Lin Li, Fang Yan, Zhong-Ying Liu, Wei-Ren Dong, Lin Zhang, Hai-Hong Wang   +10 more
doaj   +1 more source

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. [PDF]

, 2019
HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors.
Brichacek, Beda, Bukrinsky, Michael, Ditiatkovski, Michael, Dragoljevic, Dragana, Dubrovsky, Larisa, Fu, Ying, Hoang, Anh, Horvath, Anelia, Low, Hann, Meikle, Peter J, Miller, Yury I, Mukhamedova, Nigora, Murphy, Andrew, Ohkawa, Ryunosuke, Pushkarsky, Tatiana, Sviridov, Dmitri   +15 more
core   +3 more sources

GTPase-Activating Proteins for Cdc42 [PDF]

Eukaryotic Cell, 2002
ABSTRACT The Rho-type GTPase, Cdc42, has been implicated in a variety of functions in the yeast life cycle, including septin organization for cytokinesis, pheromone response, and haploid invasive growth. A group of proteins called GTPase-activating proteins (GAPs) catalyze the hydrolysis of GTP to GDP, thereby inactivating Cdc42.
Gregory R, Smith, Scott A, Givan, Paul, Cullen, George F, Sprague   +3 more
openaire   +2 more sources

Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK [PDF]

, 2015
The GTPases belonging to the Rho family control the actin cytoskeleton rearrangements needed for particle internalization during phagocytosis. ROCK and mDia1 are downstream effectors of RhoA, a GTPase involved in that process.
A Alonso, A Schonichen, A Subtil, A Tierrez, A Yoneda, AB Hall, AB Jaffe, AD Hoppe, AL Bishop, AP Wheeler, AR Frampton Jr., AS Alberts, B Qualmann, BJ Wallar, C Capo, C Cougoule, C Yang, CA Burnham, CM Haglund, CW Gourlay, D Howe, D Michaelson, D Michaelson, D Truong, Daniel E. Voth, DE Voth, DJ Hackam, DM Underhill, DM Waag, DT Brandt, E Alix, E Caron, E Colucci-Guyon, E Lemichez, EJ van Schaik, EM Rosales, EN Firat-Karalar, F Li, F Matsumura, F Niedergang, G Kaplan, GD Fairn, H Bierne, H Bierne, H Genth, HJ Newton, IM Olazabal, J Dellacasagrande, J Faix, J Hanisch, J Pizarro-Cerda, J Pizarro-Cerda, JA McDonough, JA Swanson, JC Patel, JC Patel, JE Heindl, Jesús S. Distel, JG Duman, JG Kim, K Aktories, K Bhadriraju, L Hodgson, LA Allen, M Aguilera, M Amano, M Amano, M Fernandez-Borja, M Kaksonen, M Ladwein, María I. Colombo, MG Gutierrez, Milton O. Aguilera, ML Gardel, N Ramalingam, N Watanabe, N Watanabe, NA Khan, O Billker, O Pertz, O Pertz, OB Matas, OG Baca, OG Baca, P Aspenstrom, P Cossart, P Croise, P Hotulainen, PJ Roberts, PS Romano, R Fox, RA Carabeo, RC May, RC May, Rodolfo M. Ortiz Flores, Romina P. Salinas, RS Flannagan, S Meconi, SJ Heasman, SK Hussain, T Dubois, T Tominaga, V Benard, VC Tam, W Beron, Walter Berón, WI Goh, X Chi, XD Ren, Z Woldehiwet   +109 more
core   +8 more sources

Regulation of polarised growth in fungi [PDF]

, 2008
Polarised growth in fungi occurs through the delivery of secretory vesicles along tracks formed by cytoskeletal elements to specific sites on the cell surface where they dock with a multiprotein structure called the exocyst before fusing with the ...
Adamo, Adamo, Adams, Akashi, Ayad-Durieux, Bachewich, Bartnicki-Garcia, Bartnicki-Garcia, Bassilana, Bassilana, Bassilana, Behrens, Berman, Bidlingmaier, Bose, Boyce, Boyce, Boyce, Boyd, Brown, Caviston, Chant, Chapa y Lazo, Collinge, Colman-Lerner, Court, Crampin, Cvrckova, Dong, Drgonova, Dunkler, Feng, Finger, France, Gao, Girbardt, Gladfelter, Goehring, Gorovits, Gulli, Guo, Harris, Harris, Hartwell, Hergovich, Hou, Hou, Irazoqui, Jin, Karnoub, Knechtle, Kohno, Konzack, Kron, Leberer, Leberer, Leberer, Leonhard, Lew, Li, Liu, Loeb, Loeb, Longtine, Mahlert, Mata, McCollum, McCusker, Medkova, Mehta, Mendenhall, Nelson, Nonaka, Novick, Pan, Park, Pearson, Peter, Peter E. Sudbery, Philippsen, Punt, Qadota, Racki, Read, Santangelo, Schmidt, Seiler, Seiler, Sinha, Smith, Soll, Stevenson, Sudbery, Sudbery, Sudbery, Tamaskovic, Tanaka, Tcheperegine, Trinci, Verde, Versele, Virag, Virag, Walton, Walworth, Wedlich-Soldner, Wedlich-Soldner, Wendland, Wu, Yarden, Zhang, Zheng, Zheng   +112 more
core   +1 more source

Regulation of Cdc42 and its effectors in epithelial morphogenesis

Journal of Cell Science, 2019
Cdc42 – a member of the small Rho GTPase family – regulates cell polarity across organisms from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial cells, through coordination of apical membrane morphogenesis, lumen ...
F. Pichaud, Rhian F. Walther, Francisca Nunes de Almeida   +2 more
semanticscholar   +1 more source

Cdc42 Effector Protein 3 Interacts With Cdc42 in Regulating Xenopus Somite Segmentation [PDF]

Frontiers in Physiology, 2019
Somitogenesis is a critical process during vertebrate development that establishes the segmented body plan and gives rise to the vertebra, skeletal muscles, and dermis. While segmentation clock and wave front mechanisms have been elucidated to control the size and time of somite formation, regulation of the segmentation process that physically ...
Mary Kho, Hongyu Shi, Shuyi Nie, Shuyi Nie, Shuyi Nie   +4 more
openaire   +3 more sources

Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview

Endocrine Regulations, 2016
The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides ...
Lestanova Z., Bacova Z., Bakos Jan
doaj   +1 more source

Mitosis can drive cell cannibalism through entosis

eLife, 2017
Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis.
Joanne Durgan, Yun-Yu Tseng, Jens C Hamann, Marie-Charlotte Domart, Lucy Collinson, Alan Hall, Michael Overholtzer, Oliver Florey   +7 more
doaj   +1 more source