Results 61 to 70 of about 75,568 (261)
Spatial Regulation of Cdc42 During Cytokinesis [PDF]
Cell Cycle, 2007 Cdc42 GTPase plays a critical role in the establishment of cell polarity in most eukaryotic organisms. Cdc42 active state, as that of other GTPases, depends on the bound nucleotide. The protein with GTP is active, and only in this state can it interact with different target effector proteins.
Rincón Padilla, Sergio A. +2 more
openaire +3 more sources
Effects of cdc42 gene knockout by CRISPR/Cas9 technology on osteochondral development in zebrafish
陆军军医大学学报Objective To knock out cdc42 gene in zebrafish using CRISPR/Cas9 technology, and investigate the effect of cdc42 on early osteochondral development.
YANG Yunfei, LI Yi, SUN Xianding
doaj +1 more source
Libyan Journal of Medicine, 2023 Vascular calcification (VC) is prevalent in uremia patients, lacking effective molecular biomarkers. This study was conducted to explore the role of serum cell division cycle 42 (CDC42) in the diagnosis of uremic VC incidence and progression. We enrolled
Mingzhi Xu +7 more
doaj +1 more source
Myelination: all about Rac n roll. [PDF]
, 2007 During the development of the peripheral nervous system, Schwann cells select individual axons from a nerve bundle and establish a one-to-one relationship through a process termed radial sorting. Recent findings identify the Rho family GTPase Rac1 as the
Chan, Jonah
core +2 more sources
Cdc42 Regulates Microtubule-Dependent Golgi Positioning [PDF]
Traffic, 2010 The molecular mechanisms underlying cytoskeleton-dependent Golgi positioning are poorly understood. In mammalian cells, the Golgi apparatus is localized near the juxtanuclear centrosome via dynein-mediated motility along microtubules. Previous studies implicate Cdc42 in regulating dynein-dependent motility.
Heidi, Hehnly +3 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation. [PDF]
, 2017 Cool-associated tyrosine-phosphorylated protein 1 (Cat-1) is a signaling scaffold as well as an ADP-ribosylation factor-GTPase-activating protein. Although best known for its role in cell migration, we recently showed that the ability of Cat-1 to bind ...
Antonyak, Marc A. +3 more
core +2 more sources
Advanced Functional Materials, EarlyView.A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam +8 more
wiley +1 more source
European Journal of Cell Biology, 2022 Metastasis remains the main challenge to overcome for treating ovarian cancers. In this study, we investigate the potential role of the Cdc42 GAP StarD13 in the modulation of cell motility, invasion in ovarian cancer cells.
Sandra Abdellatef +9 more
doaj +1 more source
The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion. [PDF]
, 2014 Cell polarization relies on small GTPases, such as Cdc42, which can break symmetry through self-organizing principles, and landmarks that define the axis of polarity.
Gallo Castro, D. +2 more
core +2 more sources