Results 61 to 70 of about 86,770 (308)
Cells, 2019 : T cell activation is immediately followed by internalization of the T cell receptor (TCR). TCR endocytosis is required for T cell activation, but the mechanisms supporting removal of TCR from the cell surface remain incompletely understood.
Pascal Rossatti +5 more
doaj +1 more source
Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation. [PDF]
, 2017 Cool-associated tyrosine-phosphorylated protein 1 (Cat-1) is a signaling scaffold as well as an ADP-ribosylation factor-GTPase-activating protein. Although best known for its role in cell migration, we recently showed that the ability of Cat-1 to bind ...
Antonyak, Marc A. +3 more
core +2 more sources
CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression
Circulation Research, 2019 Rationale: Aberrant formation of blood vessels precedes a broad spectrum of vascular complications; however, the cellular and molecular events governing vascular malformations are not yet fully understood.
Marco Castro +8 more
semanticscholar +1 more source
Chronic inflammation evoked by pathogenic stimulus during carcinogenesis
4 open, 2019 A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Myelination: all about Rac n roll. [PDF]
, 2007 During the development of the peripheral nervous system, Schwann cells select individual axons from a nerve bundle and establish a one-to-one relationship through a process termed radial sorting. Recent findings identify the Rho family GTPase Rac1 as the
Chan, Jonah
core +2 more sources
Development, 2019 Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-aPKC), Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work together and interact during epithelial morphogenesis is not well understood.
Francisca Nunes de Almeida +4 more
semanticscholar +1 more source
Journal of Cell Biology, 2015 In 1990, John Pringle and colleagues identified the small GTPase and demonstrated its role in yeast cell polarization.
openaire +2 more sources
Spatial Regulation of Cdc42 During Cytokinesis [PDF]
Cell Cycle, 2007 Cdc42 GTPase plays a critical role in the establishment of cell polarity in most eukaryotic organisms. Cdc42 active state, as that of other GTPases, depends on the bound nucleotide. The protein with GTP is active, and only in this state can it interact with different target effector proteins.
Rincón Padilla, Sergio A. +2 more
openaire +3 more sources
Libyan Journal of Medicine, 2023 Vascular calcification (VC) is prevalent in uremia patients, lacking effective molecular biomarkers. This study was conducted to explore the role of serum cell division cycle 42 (CDC42) in the diagnosis of uremic VC incidence and progression. We enrolled
Mingzhi Xu +7 more
doaj +1 more source
Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]
, 2016 During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo +5 more
core +2 more sources