Results 31 to 40 of about 27,912 (176)

Identification of an Autoinhibitory Domain of p21-activated Protein Kinase 5 [PDF]

, 2003
The p21-activated protein kinases (Paks) are serine/threonine protein kinases activated by binding to Rho family small GTPases, Rac and Cdc42. Recently, Pak family members have been subdivided into two groups, I and II.
Ching, YP, Kung, HF, Leong, VYL, Wong, CM   +3 more
core   +2 more sources

Suppl. Fig. S8 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42 [PDF]

, 2023
Julia I. Medina, Ailed Cruz‐Collazo, María del Mar Maldonado, Tatiana Matos Gascot, Luis D. Borrero-García, Mariana Cooke, Marcelo G. Kazanietz, Eliud Hernandez O'Farril, Cornelis P. Vlaar, Suranganie Dharmawardhane   +9 more
openalex   +2 more sources

Suppl. Fig. S3 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42 [PDF]

, 2023
Julia I. Medina, Ailed Cruz‐Collazo, María del Mar Maldonado, Tatiana Matos Gascot, Luis D. Borrero-García, Mariana Cooke, Marcelo G. Kazanietz, Eliud Hernandez O'Farril, Cornelis P. Vlaar, Suranganie Dharmawardhane   +9 more
openalex   +2 more sources

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells [PDF]

, 2014
Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity,
Alonso, Daniel Fernando, Cardama, Georgina Alexandra, Ciarlantini, Matias Sebastián, Comin, Maria Julieta, Gandolfi Donadío, Lucía, Gomez, Daniel Eduardo, González, Nazareno, Lorenzano Menna, Pablo   +7 more
core   +2 more sources

Suppl. Fig. S1 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42 [PDF]

, 2023
Julia I. Medina, Ailed Cruz‐Collazo, María del Mar Maldonado, Tatiana Matos Gascot, Luis D. Borrero-García, Mariana Cooke, Marcelo G. Kazanietz, Eliud Hernandez O'Farril, Cornelis P. Vlaar, Suranganie Dharmawardhane   +9 more
openalex   +2 more sources

PAKing up to the endothelium [PDF]

, 2009
Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be ...
Armelle Le Guelte, Eva Maria, Galan Moya, Julie Gavard   +3 more
core   +6 more sources

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

The Chlamydia pneumoniae effector SemD exploits its host’s endocytic machinery by structural and functional mimicry

Nature Communications
To enter epithelial cells, the obligate intracellular pathogen Chlamydia pneumoniae secretes early effector proteins, which bind to and modulate the host-cell’s plasma membrane and recruit several pivotal endocytic host proteins.
Fabienne Kocher, Violetta Applegate, Jens Reiners, Astrid Port, Dominik Spona, Sebastian Hänsch, Amin Mirzaiebadizi, Mohammad Reza Ahmadian, Sander H. J. Smits, Johannes H. Hegemann, Katja Mölleken   +10 more
doaj   +1 more source

Suppl. Fig. S6 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42 [PDF]

, 2023
Julia I. Medina, Ailed Cruz‐Collazo, María del Mar Maldonado, Tatiana Matos Gascot, Luis D. Borrero-García, Mariana Cooke, Marcelo G. Kazanietz, Eliud Hernandez O'Farril, Cornelis P. Vlaar, Suranganie Dharmawardhane   +9 more
openalex   +2 more sources

Investigation of the TOCA1-Cdc42 interaction [PDF]

, 2016
Transducer of Cdc42-dependent actin assembly protein 1 (TOCA1) is an effector of the Rho family small G protein Cdc42. It contains a membrane-deforming F-BAR domain as well as a Src homology 3 (SH3) domain and a G protein-binding homology region 1 (HR1 ...
Fox, Helen M, Gallop, Jennifer L, Mott, Helen R, Nietlispach, Daniel, Owen, Darerca, Watson, Joanna R   +5 more
core   +2 more sources