Results 41 to 50 of about 25,474 (119)

Suppl. Fig. S2 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

open access: yes, 2023
<p>Supplemental Figure S2 shows the Effect of MBQ compounds on cell migration</p>
Suranganie Dharmawardhane   +9 more
openaire   +1 more source

Mutation p.R356Q in the Collybistin Phosphoinositide Binding Site Is Associated With Mild Intellectual Disability

open access: yesFrontiers in Molecular Neuroscience, 2019
The recruitment of inhibitory GABAA receptors to neuronal synapses requires a complex interplay between receptors, neuroligins, the scaffolding protein gephyrin and the GDP-GTP exchange factor collybistin (CB). Collybistin is regulated by protein-protein
Tzu-Ting Chiou   +10 more
doaj   +1 more source

Suppl. Fig. S8 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

open access: yes, 2023
<p>Supplementary Figure S8 shows nucleotide loading of GTP binding to Rho GTPases.</p>
Suranganie Dharmawardhane   +9 more
openaire   +1 more source

Supplementary Methods SM1 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

open access: yes, 2023
<p>Supplementary methods</p>
Suranganie Dharmawardhane   +9 more
openaire   +1 more source

Self-organization principles of intracellular pattern formation [PDF]

open access: yes, 2018
Dynamic patterning of specific proteins is essential for the spatiotemporal regulation of many important intracellular processes in procaryotes, eucaryotes, and multicellular organisms. The emergence of patterns generated by interactions of diffusing proteins is a paradigmatic example for self-organization. In this article we review quantitative models
arxiv   +1 more source

Dependence of protein-induced lipid bilayer deformations on protein shape [PDF]

open access: yes, 2022
Membrane proteins typically deform the surrounding lipid bilayer membrane, which can play an important role in the function, regulation, and organization of membrane proteins. Membrane elasticity theory provides a beautiful description of protein-induced lipid bilayer deformations, in which all physical parameters can be directly determined from ...
arxiv   +1 more source

Suppl. Fig. S7 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

open access: yes, 2023
<p>Supplementary Figure S7 shows the effect of MBQ-167 on Rac1(G15A) association with Tiam-1 and p-REX-1.</p>
Suranganie Dharmawardhane   +9 more
openaire   +1 more source

Global well-posedness for volume-surface reaction-diffusion systems [PDF]

open access: yesarXiv, 2021
We study the global existence of classical solutions to volume-surface reaction-diffusion systems with control of mass. Such systems appear naturally from modeling evolution of concentrations or densities appearing both in a volume domain and its surface, and therefore have attracted considerable attention.
arxiv  

Paradoxical signaling regulates structural plasticity in dendritic spines [PDF]

open access: yes, 2016
Transient spine enlargement (3-5 min timescale) is an important event associated with the structural plasticity of dendritic spines. Many of the molecular mechanisms associated with transient spine enlargement have been identified experimentally. Here, we use a systems biology approach to construct a mathematical model of biochemical signaling and ...
arxiv   +1 more source

Genome-Wide Analysis of Gene and Protein Expression of Dysplastic Naevus Cells

open access: yesJournal of Skin Cancer, 2012
Cutaneous melanoma, a type of skin tumor originating from melanocytes, often develops from premalignant naevoid lesions via a gradual transformation process driven by an accumulation of (epi)genetic lesions.
Linda Gao   +7 more
doaj   +1 more source

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