Results 101 to 110 of about 118,570 (219)

Intestinal Organoid‐Based Mathematical Modeling Predicts Clinical Gastrointestinal Toxicity of Oral Oncology Drugs

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Gastrointestinal (GI) toxicity is a common and potentially severe side effect of antiproliferative cancer therapies that often requires dose reduction or treatment interruption. Despite the clinical implications, there are currently no robust strategies for quantitative preclinical assessment of GI toxicity.
Carmen Pin, Deepa Maheshvare M., Louis Gall, Andrew Hall, Muireann Coen, Ambra Bianco, Shimeng Liu, Kenneth Pryde   +7 more
wiley   +1 more source

New predicted dual CDK-2/CDK-1 inhibitors from Aspergillus unguis isolate SP51-EGY with relative selectivity for colorectal cancer cells: a computational and experimental approach. [PDF]

Sci Rep
El-Rashedy AA, Ibrahim AM, Abdel-Aziz MS, Fayad W, El-Hady FKA.   +4 more
europepmc   +1 more source

10000 CDK commits!

, 2008
It has happened. Just a few minutes ago. The 10000th commit to the CDK source code repository. Miguel was the lucky(?) one.
openaire   +1 more source

The Epistemic Generativity of Using a Model of a Big Idea

Science Education, Volume 110, Issue 3, Page 803-825, May 2026.
ABSTRACT Science instruction should involve learners in generating and warranting ideas, what we call epistemic generation. In modeling instruction, epistemic generation should be achieved by coordinating a model structure with the experienced world in reciprocal directions denoted as developing models and using models. In the former, a model structure
Jonathan T. Shemwell, Daniel K. Capps
wiley   +1 more source

Correction: Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II. [PDF]

J Cell Biol
Yang J, Sumiyoshi E, Bowerman B.
europepmc   +1 more source

CDK Literature #2

, 2007
Second in a series of articles summarizing articles that cite one of the main CDK articles for CDK News. The first CDK Literature was already half a year ago, so it was about time.
openaire   +1 more source

Elucidating R‐gene‐mediated resistance to wheat dwarf virus in Triticum aestivum genotypes

Annals of Applied Biology, Volume 188, Issue 3, Page 947-961, May 2026.
This study investigates R‐gene‐mediated resistance to wheat dwarf virus (WDV) among different wheat genotypes. Following inoculation with Psammotettix alienus (leafhoppers) and the subsequent appearance of characteristic symptoms such as yellowing and dwarfing, phenotypic responses were evaluated alongside molecular analyses, including quantification ...
Priyanka Krishnamurthy, Emad Ibrahim, Jan Ripl, Jiban K. Kundu   +3 more
wiley   +1 more source

Development, anti-proliferative activity, multi-target kinase inhibition against CHK1, PIM1, and CDK-2, and computational insights of new thiazole-based hybrids. [PDF]

RSC Adv
Altwaijry NA, Othman IMM, Anwar MM, Nosier SS, Saleh A, Tashkandi NY, Nossier ES.   +6 more
europepmc   +1 more source

Preoperative Beta‐Hydroxy‐Beta‐Methyl‐Butyrate Supplementation Reduces Mitochondrial Dynamics Proteins and Preserves Hepatic Mitochondrial Function After Partial Hepatectomy in Mice

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim The liver exhibits a remarkable regenerative capacity, enabling this organ to maintain homeostasis even after significant injury. However, hepatic regeneration requires sufficient energy to sustain cellular hypertrophy and proliferation, thus ensuring efficient tissue repair.
A. L. Vieira‐da‐Silva, M. V. Esteca, F. A. Silva, I. A. Divino, F. S. Carneiro, E. R. Ropelle, A. S. Torsoni, I. L. Baptista   +7 more
wiley   +1 more source

Emerging Strategies to Inhibit the G1/S Transition for Cancer Therapy. [PDF]

Cancer Res
Rubin SM, Sage J, Skotheim JM.
europepmc   +1 more source