Results 111 to 120 of about 57,522 (220)

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

A patent review of cyclin-dependent kinase 5 (CDK5) inhibitors (1999-2025). [PDF]

Front Bioeng Biotechnol
Derzhavina VM, Khalymbadzha IA, Yuzhalin AE.   +2 more
europepmc   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Design, synthesis, anticancer activity, and mechanistic investigation of 4,5,6,7-tetrahydrobenzo[<i>b</i>]thiophene carboxamides as CDK-2 inhibitors: <i>in vitro</i> and <i>in silico</i> DFT and molecular docking study. [PDF]

J Enzyme Inhib Med Chem
Anwer KE, Ramadan RM, Nossier ES, Altwaijry NA, Saleh A, Bräse S, Husseiny EM.   +6 more
europepmc   +1 more source

PubChem-CDK

, 2009
PubChem-CDK is a project that runs CDK code on the PubChem data. As we speak, a groovy script reads about 100 PubChem Compounds XML entries per second into the database. Mind you, not the SDF they distribute which uses a custom extension to overcome the limits of the real MDL SDF format.
openaire   +1 more source

RIOK2 Promotes Clear Cell Renal Cell Carcinoma Progression Through Cell Cycle Regulation

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of kidney cancer and is frequently associated with poor clinical outcomes. Ribosome biogenesis, which is upregulated in many malignancies, plays a key role in tumor proliferation.
Hiroyuki Shikuma, Keisuke Goto, Ayako Shimo, Tomoya Hatayama, Kazuma Yukihiro, Kyosuke Iwane, Ryoken Yamanaka, Ryo Tasaka, Yuki Kohada, Kenshiro Takemoto, Kohei Kobatake, Yohei Sekino, Hiroyuki Kitano, Akihiro Goriki, Keisuke Hieda, Osamu Kaminuma, Nobuyuki Hinata   +16 more
wiley   +1 more source

From Basics to Benchmarks: Evaluating Sample Adequacy, PD‐L1 Expression, and Molecular Profiling in Effusion Samples of Lung Adenocarcinoma

Diagnostic Cytopathology, Volume 54, Issue 8, Page 547-555, August 2026.
ABSTRACT Introduction Lung adenocarcinoma commonly causes malignant pleural effusion (MPE), a condition with poor prognosis and limited treatment options. Pleural effusion specimens offer a minimally invasive source for diagnosis and molecular testing.
Harpreet Virk, Claire Michael, Keri Ann Pfeil, Navid Sadri, Omid Savari, Aparna Harbhajanka   +5 more
wiley   +1 more source

CDK - The Documentation

, 2009
In preparation for the CDK workshop later this month, I am writing up my material for my kick-off presentation of the workshop. So, I better make it good. Using LaTeX at least overcomes my laziness which always made Word documents look stupid.
openaire   +1 more source

The Potential Role of MicroRNAs as Cardioprotective Agents During Cardioplegia: A Preliminary Qualitative Systematic Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Recent advancements in gene expression studies have shed light on the role of non‐coding RNAs in negatively regulating mRNA and inhibiting mRNA translation. Given the significant impact of miRNAs on cardiovascular function, our review aims to comprehensively explore their contribution to mitigating heart injury and their ...
Maryam Baniani, Ali Dabbagh, Pourya Shokri, Firoozeh Madadi   +3 more
wiley   +1 more source

Cell cycle oscillations in a polarity network facilitate state switching by morphogenetic cues. [PDF]

Sci Adv
Ng K, Sebaa H, Hirani N, Chizh A, Messi Z, Bland T, Sugioka K, Goehring NW.   +7 more
europepmc   +1 more source