Results 111 to 120 of about 72,294 (253)

CDK-inhibitor olomoucine inhibits cell death after exposure of cell lines to cytosine-arabinoside

, 1999
Signal transduction for apoptosis or programmed cell death, after DNA damage in mammalian cells, is believed to involve activation of cyclin-dependent kinases (CDKs), especially CDK-1 (cdc2) and CDK-2.
Dimitriadis, K. A., Papazisis, K. T., Konstantinos A. Dimitriadis, Konstantinos T. Papazisis, George D. Geromichalos, Alexander H. Kortsaris, Kouretas, D., Kortsaris, A. H., Demetrios Kouretas, Geromichalos, G. D.   +9 more
core   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

FEWT: Frequency‐Enhanced Wavelet‐Based Transformer for Multimodal Wheeled Bimanual Manipulation

SmartBot, EarlyView.
An embodied mobile bimanual robot learns dexterous manipulation skills through imitation learning with multimodal perception. The integration of vision, proprioception, and tactile sensing establishes a comprehensive perception–action loop, enabling the robot to continuously understand, interact with, and adapt to complex physical environments.
Jiaxin Huang, Hanyu Liu, Yunsheng Ma, Jian Shen, Yilin Zheng, Jiayi Wen, Zhigong Song   +6 more
wiley   +1 more source

Herpes Simplex Virus 1 Upregulates p 35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons [PDF]

, 2015
The cyclin-dependent kinase 5 (CDK-5) activating protein, p35, is important for acute herpes simplex virus 1 (HSV-1) replication in mice. This report shows that HSV-1 increases p35 levels, changes the primary localization of CDK-5 from the nucleus to the
van Loben Sels, Jessica M., Mostafa, Heba H., Davido, David J.   +2 more
core   +1 more source

Carbon‐Modified SnS2/g‐C3N4 S‐Scheme Heterostructure with Enhanced Interfacial Charge Transfer for Efficient Photocatalytic Reduction of Cr(VI) and 4‐Nitrophenol

Small, EarlyView.
The S‐scheme of SnS2‐C/g‐C3N4 heterostructure enables Photocatalytic Cr(VI) and 4‐NP reduction. ABSTRACT Hexavalent chromium (Cr(VI)) and 4‐nitrophenol (4‐NP) are persistent and highly toxic water pollutants that require efficient treatment under mild conditions. In this work, L‐cysteine‐derived carbon‐modified SnS2 (SnS2‐C) was prepared hydrothermally
Dhayanantha Prabu Jaihindh, Dinesh Kumar Dhanthala Chittibabu, Gabriella Janed Johana Sijabat, Saravanakumar Muthusamy, Jayaseelan Dhakshinamoorthy, Dang Manh Phuc, Tzu‐Ting Chang, Hsin‐Tsung Chen, Yi‐Feng Lin   +8 more
wiley   +1 more source

Cdk-counteracting phosphatases unlock mitotic exit

, 2008
Entry into mitosis of the eukaryotic cell cycle is driven by rising cyclin-dependent kinase (Cdk) activity. During exit from mitosis, Cdk activity must again decline.
Queralt, Ethel, Uhlmann, Frank
core   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Diflubenzuron Caused Mitochondrial Dysfunction, Ca2+ Homeostasis Disruption, and Intrinsic Apoptosis in Trophoblastic Cells

Environmental Toxicology, EarlyView.
ABSTRACT Diflubenzuron is used as an insect growth inhibitor, and its potential risk to human health was raised owing to the possibility of environmental residues and human exposure. This study aimed to investigate the toxic mechanism of diflubenzuron on trophoblastic cells such as HTR8/SVneo and JEG‐3 cells. We investigated mitochondrial function, Ca2+
Miji Kim, Wonhyoung Park, Whasun Lim, Gwonhwa Song, Sunwoo Park   +4 more
wiley   +1 more source

cdk/cdk: Patch Release of 2.1

, 2016
<p>This patch release removes the SNAPSHOT dependency.</p ...
John Mayfield, LuisFF, Syed Asad Rahman, Klas Jönsson, Yap Chun Wei, philopon, Arvid Berg, Alex Clark, zachcp, Oliver Stueker, Uli Köhler, Tomáš Pluskal, Rajarshi Guha, kaibioinfo, Daniel Szisz, Ralf Stephan, Dmitry Katsubo, Luis F. de Figueiredo, Noel O'Boyle, PeterOdeus, rafeli, Nina Jeliazkova, AndyHowlettGitHub, Cyrus Harmon, Onkar, Jonathan Alvarsson, Nikolay Kochev, gilleain torrance, Kazuya Ujihara, Mark Williamson, Stephan Beisken, Mark J. Williamson, Egon Willighagen, sambitgaan, mbv31602, kdole   +35 more
core   +1 more source