Results 111 to 120 of about 118,570 (219)

Efficacy and Safety of Prophylaxis With a Plasma‐Derived von Willebrand Factor/Factor VIII Concentrate (Wilate) in Patients With Type 3 von Willebrand Disease—A WIL‐31 Study Sub‐Analysis

European Journal of Haematology, Volume 116, Issue 5, Page 674-681, May 2026.
ABSTRACT Objectives The WIL‐31 study demonstrated efficacy and safety of prophylaxis with the plasma‐derived von Willebrand factor/factor VIII concentrate wilate in von Willebrand disease (VWD) of all types and was the only prospective study with an on‐demand run‐in study as an intra‐individual comparator.
Claudia Djambas Khayat, Leonid Dubey, Adlette Inati, Toshko Lissitchkov, Dzmitry Novik, Elina Peteva, Robert F. Sidonio Jr, Ali T. Taher, Kateryna V. Vilchevska, Vladimir Vdovin, Ana Boban   +10 more
wiley   +1 more source

Phase I/II Study of the CDK2/9 Inhibitor Fadraciclib in Combination with Chemotherapy in Children with Advanced Malignancies: Arm K of the AcSé-ESMART Trial. [PDF]

Target Oncol
Rubio-San-Simón A, Marshall LV, Karamouza E, André N, Abbou S, Rubino J, Nebchi S, Aerts I, Thebaud E, Brisset C, Ducassou S, Le Teuff G, Geoerger B.   +12 more
europepmc   +1 more source

Cell cycle follows ‘pause and play’ mechanism in salt and cold stress recovery in diverse plant species

New Phytologist, Volume 250, Issue 3, Page 1689-1703, May 2026.
Summary Changes to organismal growth induced by environmental stress are orchestrated at the cellular level. These periods of stress may be followed by recovery periods, when plants have the opportunity to return to normal growth conditions. However, the cell cycle mechanisms underlying recovery are poorly understood.
Olivia S. Hazelwood, Kamryn A. Diehl, Vicky Hollenbeck, Joh Demura‐Devore, Dustin Herb, Joseph P. Gallagher, M. Arif Ashraf   +6 more
wiley   +1 more source

Novel indole-based scaffolds: Design, synthesis, molecular modeling, and anti-proliferative evaluation. [PDF]

BMC Chem
Mohamed-Ezzat RA, Al-Ashmawy AAK, Srour AM.   +2 more
europepmc   +1 more source

The PagDMG6341–PagWD40–PagPOLD4 Module Coordinates Base Excision Repair in ‘84K’ Poplar (Populus alba × P. glandulosa)

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2956-2969, May 2026.
ABSTRACT Base excision repair (BER) is a critical pathway for repairing damaged DNA bases in cells; however, the mechanisms of protein recruitment and interaction in this pathway remain largely unexplored in higher plants. In this study, we used ‘84K’ poplar (Populus alba × P.
Aoyu Ling, Yijia Jin, Yufei Xia, Shenxiu Jiang, Jianghai Shu, Xiaotong Hu, Kang Du, Pingdong Zhang, Xiangyang Kang   +8 more
wiley   +1 more source

The Binding of 3‐O‐Methylfluorescein Phosphate to the Catalytic Domain of the Human CDC25B Phosphatase: A Structural Investigation

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Structural studies on the complex that CDC25B C473S (CDC25B‐S) forms with the 3‐O‐methylfluorescein phosphate (3‐OMFP) reveal how the fluorogenic substrate binds CDC25B‐S, engaging key binding regions and inducing structural adjustments that stabilize the protein.
Romualdo Troisi, Rosario Rullo, Valeria Napolitano, Grzegorz M. Popowicz, Emmanuele De Vendittis, Filomena Sica   +5 more
wiley   +1 more source

Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II. [PDF]

J Cell Biol
Yang J, Sumiyoshi E, Bowerman B.
europepmc   +1 more source

The discovery of plant D-type cyclins [PDF]

, 2019
De Veylder, Lieven
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, Volume 20, Issue 4, Page 1022-1040, April 2026.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Selective CDK4/9 Inhibitors. [PDF]

ACS Med Chem Lett
Li S, Yang X, Yin W, Zhang W, Li Z, Hu J, Li Y.   +6 more
europepmc   +1 more source