Results 131 to 140 of about 118,570 (219)

Biopharmaceuticals for Cancer Treatment: An Update

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath, Yousuf Alam, Afsana Mustak Mim, Maksuda Akter, Mohammad Abbas Gani, Khondaker Muhammad Khairul Alam, Md. Nur Alam   +6 more
wiley   +1 more source

A CDK-4EBP1 signaling axis drives HSV-1 replication and underscores a druggable pathway for potent antiviral intervention. [PDF]

mBio
Madavaraju K, Yadavalli T, Singh SK, Patil CD, Borase H, Shukla D.   +5 more
europepmc   +1 more source

Effects of Tumor Microenvironment on Lung Cancer Stem Cells: Bidirectional Regulatory Mechanisms

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Lung cancer, with a high mortality rate, poses challenges in treatment due to its invasiveness and heterogeneity. Lung cancer stem cells (LCSCs) are considered key contributors to recurrence and metastasis because of their self‐renewal, pluripotency, and drug resistance.
Hongyi Lai, Ruihang Luo, Wei Zou, Xuyang Liu, Maosen Liu, Mingshan Liu, Jingtao Zhang   +6 more
wiley   +1 more source

Considerations for establishing occupational exposure limits for small molecule kinase inhibitors in drug development. [PDF]

Front Toxicol
Nicholas T, Morinello E, Moudgal C, Beaulieu A, Graham J.   +4 more
europepmc   +1 more source

Biochemical Characterization of a Kunitz‐Type Protease Inhibitor From Mimosa regnellii and Its Effects on Melanoma Cell Viability and Angiogenesis

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
A Kunitz‐type serine protease inhibitor (JTI) purified from Mimosa regnellii seeds selectively targets melanoma cells. JTI triggers mitochondrial apoptosis, increases ROS and Ca2+ levels, arrests the cell cycle, and suppresses migration and angiogenesis without affecting healthy cells.
Luciana Maria Araújo Rabêlo, Pedro Henrique de Oliveira Cardoso, Leonardo Thiago Duarte Barreto Nobre, Paula Ivani Medeiros dos Santos, Sheyla Varela Lucena, Raphael Paschoal Serquiz, Marcelo Porto Bemquerer, Hugo Alexandre de Oliveira Rocha, Helena Bonciani Nader, Elizeu Antunes dos Santos, Adeliana Silva de Oliveira, Breno Emanuel Farias Frihling, Ludovico Migliolo   +12 more
wiley   +1 more source

Evaluation of New Coumarins for Anti-Cancer Activity in HL-60 Cell Line Supported by Molecular Docking, MD Simulation, and Binding Free Energy Calculations. [PDF]

Onco Targets Ther
Humayun N, Rabbi F, Sohail M, Khan A, Zeb A, Nisar A, Rahim A, Shao C, Wang S, Younas A.   +9 more
europepmc   +1 more source

The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis [PDF]

, 2004
Boudolf, Véronique, Vlieghe, Kobe, Beemster, Gerrit, Magyar, Zoltán, Torres Acosta, Juan Antonio, Maes, Sara, Van Der Schueren, Els, Inzé, Dirk, De Veylder, Lieven   +8 more
core   +2 more sources

Longitudinal Tumor Size and Survival Modeling for Exposure–Response Analysis of Drugs with Frequent Dose Reductions: Dose Justification of Abemaciclib in Patients with Metastatic Breast Cancer

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1070-1079, April 2026.
Abemaciclib is an oral anticancer drug indicated for treatment of HR+ HER2‐ breast cancer. Dose modifications due to side effects are frequent, thus drug exposures change over time as a result of altering the dose or temporarily withholding abemaciclib treatment.
Emmanuel Chigutsa, Sonya C. Chapman, P. Kellie Turner   +2 more
wiley   +1 more source

Congenital Knee Dislocation: A Case Report. [PDF]

Clin Case Rep
Castro-Lara M, Palencia Sagastume GE, Gaitán-Zambrano K, Baca Garcia CH, Palencia Sagastume JA, Maradiaga J.   +5 more
europepmc   +1 more source

Pandering to Persuade [PDF]

Navin Kartik, Wouter Dessein, Yeon-Koo Che   +2 more
core