Results 131 to 140 of about 57,313 (205)

Novel indole-based scaffolds: Design, synthesis, molecular modeling, and anti-proliferative evaluation. [PDF]

BMC Chem
Mohamed-Ezzat RA, Al-Ashmawy AAK, Srour AM.   +2 more
europepmc   +1 more source

The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma

MedComm, Volume 7, Issue 6, June 2026.
To define the mechanisms of sensitivity to PP2A inhibitors (PP2Ai), we combined molecular profiling of PP2Ai responses with genome‐wide genetic screens. PP2Ai preferentially target mesenchymal pancreatic ductal adenocarcinoma (PDAC) cells and engage pathways linked to transcriptional elongation, splicing, metabolism, and ER stress response factors ...
Janine Murr, Carolin Schneider, Ningjun Duan, Hazal Köse, Anantharamanan Rajamani, Xueyang He, Jonas Buchloh, Christian Hintze, Atharva Naik, Daniel Goeke, Nicole Rjasanow, Lukas Krauß, Alexandra Nguyen, Sebastian A. Widholz, Christian Schneeweis, Riccardo Trozzo, Felix Orben, Sebastian Mueller, Rupert Öllinger, Juan J Montero, Michael Dudek, Percy Knolle, Bo Kong, Volker Ellenrieder, Constanza Tapia Contreras, Elisabeth Hessmann, Marian Grade, Michael Ghadimi, Christian J. Braun, Roland Rad, Maximillian Reichert, Ulrich Keller, Roland M. Schmid, Paul L. Boutz, Dieter Saur, Matthias Wirth, Oliver H. Krämer, Günter Schneider   +37 more
wiley   +1 more source

Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II. [PDF]

J Cell Biol
Yang J, Sumiyoshi E, Bowerman B.
europepmc   +1 more source

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

CMGC Kinases in Viral Infection and Human Disease. [PDF]

Pathogens
Amusan OT, Guo H.
europepmc   +1 more source

Integrative Proteogenomic Characterization of Left‐Sided and Right‐Sided Colorectal Cancer

MedComm, Volume 7, Issue 6, June 2026.
This study performed whole‐exome sequencing, proteomic, and phosphoproteomic analysis on 80 pairs of tumor tissues and matched normal adjacent tissues from colorectal cancer patients. The integrated proteogenomic study provides a comprehensive and nuanced understanding of the molecular heterogeneity between left‐ and right‐sided colorectal cancer ...
An Huang, Haopeng Hong, Yonghui Sun, Zhaoya Gao, Jingxuan Xu, Jiajia Chen, Yong Yang, Zhongyi Chen, Hebing Chen, Ming Li, Xiaodong Wang, Jin Gu   +11 more
wiley   +1 more source

The effect of switching from ribociclib to palbociclib due to toxicity in hormone receptor-positive, HER2-negative metastatic breast cancer: a real-world, multicenter, retrospective study. [PDF]

Sci Rep
Oruç A, Deliktaş Onur İ, Uyar GC, Şahin TK, Tünbekici S, Arslan Kapuci A, Ulukal Karancı E, Kemik F, Yıldırım Dişli Ş, Ateş Ö, İnanç İmamoğlu G, Aksoy S, Çakar B, Özdemir N, Öztürk B, Selçukbiricik F, Koçak MZ, Karakurt Eryılmaz M, Araz M, Artaç M.   +19 more
europepmc   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

Abemaciclib Inhibits Retinoblastoma Tumor Growth by Targeting CDK1/2. [PDF]

Invest Ophthalmol Vis Sci
Yang H, Xiao Q, Shen Y, Yao Y, Yin X, Sang Y, Deng Y.   +6 more
europepmc   +1 more source