Results 151 to 160 of about 118,570 (219)

CDK Inhibitors

, 2007
Wang, Hong, Zhou, Yongming, Acosta, Juan Antonio Torres, Fowke, Larry   +3 more
openaire   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Combination of cyclin-dependent kinase 4/6 inhibitors and renin-angiotensin system inhibitors in breast cancer treatment: a promising therapeutic approach. [PDF]

Rev Assoc Med Bras (1992)
Mutlu E, İnanç M.
europepmc   +1 more source

Discovery of a First‐in‐Class Murine Double Minute 2‐Recruiting Positive Transcription Elongation Factor B PROTAC Degrader With Selective Antitumor Activity

MedComm, Volume 7, Issue 4, April 2026.
This study reports the development of dCDK9‐010, a first‐in‐class, selective MDM2‐recruiting CDK9/cyclin T PROTAC degrader with compelling in vivo antitumor efficacy and safety profile. This degrader potently inhibits RNA polymerase II phosphorylation and interferences with MDM2‐mediated p53 degradation, resulting in concurrent transcription disruption
Xian Guan, Long Xie, Hanjun Guo, Lin Ma, Jiawei Zhou, Lisong Luo, Hao Yang, Yuanfang Wu, Jiangyu Liu, Yue Wang, Xingze Huang, Jiyang Liu, Ying Zhang, Wenhao Chen, Ye Chen, Liang Xu, Xin Han   +16 more
wiley   +1 more source

The Multifaceted Role of Rad9 in the DNA Damage Response of Saccharomyces cerevisiae. [PDF]

Yeast
Kiely A, O'Halloran F, Young P, Lowndes NF, Grenon M, Finn K.   +5 more
europepmc   +1 more source

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source

Abemaciclib in meningiomas with somatic NF2 or CDK pathway alterations: the phase 2 Alliance A071401 trial. [PDF]

Nat Med
Brastianos PK, Dooley K, Geyer S, Gerstner ER, Kaufmann TJ, Iafrate AJ, Martinez-Lage M, Milhem M, Welch MR, Kaley TJ, Drappatz J, Chan A, Kumthekar P, Matsuoka CK, Strowd RE, Cohen AL, Jaeckle K, Robell L, Magge RS, Nam JY, Blondin N, Shaikh N, Rabinowitz I, Thomas AA, Piccioni DE, Brown P, Kaluziak S, Codd E, Cahill DP, Santagata S, Barker FG, Galanis E.   +31 more
europepmc   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, Volume 15, Issue 4, April 2026.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Pan-cyclin-dependent kinase inhibition is a potential treatment for adenoid cystic carcinoma that downregulates the MYB::NFIB fusion and induces tumor regression. [PDF]

Cancer Commun (Lond)
Huang J, Larsson P, Kakay Afshari M, Tejera Nevado P, Tešan Tomić T, Fehr A, Jäwert F, Stenman G, Andersson MK.   +8 more
europepmc   +1 more source

GraphReco: Probabilistic Structure Recognition for Chemical Molecules

ChemistryOpen, Volume 15, Issue 4, April 2026.
Molecule structure images are unfriendly for machine understanding, blocking productivity improvements in chemical data mining, drug discovery, and many other fields. We present a rule‐based probabilistic Optical Chemical Structure Recognition model to explain and tackle the ambiguity challenges in graph assembly.
Haidong Wang, Yuncheng Yu, Jyh‐Charn Liu   +2 more
wiley   +1 more source