Results 151 to 160 of about 57,313 (205)

Availability and Costs of Allergic Rhinitis Treatments Across the World: A Survey of ARIA Experts

Allergy, Volume 81, Issue 6, Page 2069-2078, June 2026.
We surveyed experts of the ARIA group on the costs of medications for allergic rhinitis in the respective countries. Overall, oral antihistamines are the cheapest medications while fixed combinations of antihistamines + corticosteroids are the most expensive.
Maria Clara Urbano, Rafael José Vieira, Yi‐Kui Xiang, Sara Gil‐Mata, Anna Bedbrook, Baharudin Abdullah, Mona Al‐Ahmad, Maryam Ali Al‐Nesf, Emilio Alvarez‐Cuesta, Salma Mussagy Amade, Julijana Asllani, Kazi S. Bennoor, Elena Camelia Berghea, Mario Calvo‐Gil, Luis R. Caraballo, Elizabeth Castro, Lorenzo Cecchi, Deepa Choudhury, George Christoff, Derek K. Chu, Ieva Cirule, Alvaro A. Cruz, Dejan Dokic, Bilun Gemicioglu, Maria Antonieta Guzman, Ineta Grisle, Tari Haahtela, Elham Hossny, Wolfram Hoetzenecker, Martin Hrubisko, Tomohisa Iinuma, Zhanat Ispayeva, Juan Carlos Ivancevich, Fanny Wai San Ko, Helga Kraxner, Maciej Kupczyk, Violeta Kvedariene, Yen Lam, Désirée E. Larenas‐Linnemann, Bassam Mahboub, Padukudru A. Mahesh, Mohammed Reza Masjedi, Garry McDonald, Amarilis Melendez, Florin Mihaltan, Branislava Milenkovic, Yousser Mohammad, Marek Niedoszytko, Robyn E. O'Hehir, Carmen Panaitescu, Petr Panzner, Nikolaos G. Papadopoulos, José Miguel Fuentes Perez, Nhân Pham‐Thi, Constantinos Pitsios, Davor Plavec, María Susana Repka‐Ramirez, Jan Romantowski, Marylin Valentin Rostan, Menachem Rottem, Hani Salim, Pongsakorn Tantilipikorn, Vesna Tomic‐Spiric, Arunas Valiulis, Leticia de las Vecillas, Maria Teresa Ventura, Dana Wallace, Pascal Werminghaus, Sian Williams, Francisco Javier Plaza Zamora, Ludger Klimek, Torsten Zuberbier, Ana Margarida Pereira, João A. Fonseca, Jean Bousquet, Bernardo Sousa‐Pinto   +75 more
wiley   +1 more source

Real-world second- and third-line progression-free survival after progression on first-line CDK4/6 inhibitors in HR+/HER2- metastatic breast cancer by PAM50 intrinsic subtype: the SOLTI-1801 CDK-PREDICT study. [PDF]

Breast Cancer Res Treat
Tolosa P, García-Fructuoso I, Pascual T, Martínez-Sáez O, Cejalvo JM, Servitja S, Fernández Abad M, Benitez Fuentes JD, Brasó-Maristany F, Sanfeliu E, Lema L, Ruano Y, Parrilla L, Roncero AM, Cobos MÁ, Díaz I, Centelles López KA, Sánchez-Bayona R, Alva M, Madariaga A, Villacampa G, Salvador F, Sánchez-Belmonte A, Malumbres M, Prat A, Ciruelos E.   +25 more
europepmc   +1 more source

The Recycling Endosomal (Na+, K+)/H+ Exchanger NHE6/SLC9A6 Facilitates Signal Transduction by Shuttling Cyclin‐Dependent Kinase 5 to the Plasma Membrane

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The alkali cation/proton exchanger NHE6/SLC9A6 regulates luminal pH homeostasis and trafficking of recycling endosomes in most tissues, especially neurons. Loss‐of‐function mutations in NHE6 cause Christianson Syndrome, an X‐linked neurodevelopmental and neurodegenerative disorder; however, the underlying molecular and cellular mechanisms ...
Rebecca Flessner, Alina Ilie, Léo Han, Annie Boucher, Rebecca Anne McKinney, Reza Sharif‐Naeini, John Orlowski   +6 more
wiley   +1 more source

Predictive Role of Serum Inflammatory Markers in Metastatic Luminal A/B Breast Cancers Receiving CDK-4/6 Inhibitors Therapy. [PDF]

Immun Inflamm Dis
Bulut N, Kapagan T, Ozmen A, Erdem GU.
europepmc   +1 more source

Discovery of a Novel γ‐Glutamylcyclotransferase Inhibitor Plumbagin by Luminescence‐Based High‐Throughput Screening

Cancer Science, Volume 117, Issue 6, Page 1713-1723, June 2026.
A cell‐based high‐throughput screening system utilizing the luminescent probe LISA‐103 was developed to monitor γ‐glutamylcyclotransferase (GGCT) activity in cancer cells. Through this assay, plumbagin was identified as a novel GGCT inhibitor that induces cell cycle arrest and suppresses cancer cell growth. ABSTRACT γ‐Glutamylcyclotransferase (GGCT) is
Keiko Taniguchi, Yukie Nohara, Mano Horinaka, Kozue Nose, Masaya Mori, Hiromi Ii, Hiroko Kawakami, Kazuto Yano, Susumu Nakata, Taku Yoshiya, Toshiyuki Sakai   +10 more
wiley   +1 more source

Recent Advances in Benzimidazole-Triazole Hybrids for Single- and Multi-Target Protein Kinase Inhibition. [PDF]

Pharmaceuticals (Basel)
Abu Al Rub HM, Eissa AG.
europepmc   +1 more source

Human Absorption, Metabolism, and Excretion (hAME) Mass Balance Studies in Patients With Cancer

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Radiolabeled mass balance human studies are a critical component of clinical pharmacology programs supporting the development of new investigational drugs. These studies provide information about absorption, metabolism, and excretion (AME) of the parent drug and metabolite(s) in the human body and are normally conducted in healthy volunteers ...
Begoña de las Heras, Claudine Oelke, Pamela Atwell, Hector Herrero, Paulo Nunes, Kamal S. Saini, Laura Vidal Boixader, Catherine Laing, James Bush, Emiliano Calvo   +9 more
wiley   +1 more source

A CDK-4EBP1 signaling axis drives HSV-1 replication and underscores a druggable pathway for potent antiviral intervention. [PDF]

mBio
Madavaraju K, Yadavalli T, Singh SK, Patil CD, Borase H, Shukla D.   +5 more
europepmc   +1 more source

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source

Decoding Cdk1 control: from mitotic thresholds to meiotic specificity. [PDF]

Chromosome Res
Touati SA.
europepmc   +1 more source