Advanced Science, Volume 13, Issue 56, 9 October 2026.An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu +11 more
wiley +1 more source
Efficacy and tolerability of CDK 4/6 inhibitors in HR-positive HER2-negative de novo metastatic breast cancer patients aged ≥ 70 years. [PDF]
BMC CancerAtci MM, Erciyestepe M, Erturk K.
europepmc +1 more source
Advanced Science, Volume 13, Issue 57, 14 October 2026.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon +6 more
wiley +1 more source
Targeted Degradation of CDK2: A New Strategy for Overcoming Cyclin E‑Driven Cancers. [PDF]
ACS Med Chem LettRenner AC, Kargbo RB.
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A Physical Adaptive Material Motor Unit Neural Network: A Hygromorph Composite Material Machine
Advanced Science, Volume 13, Issue 59, 23 October 2026.This study introduces a new class of material‐based intelligent machines. It presents a Physical Adaptive Material Motor Unit Neural Network, an assembly of smart 4D printed actuators and a controlling system that adapt through environmental interaction its shading behavior.
Charles de Kergariou +2 more
wiley +1 more source
Hermione Exchange Educational Program: How to Integrate Multidisciplinary Approaches to Manage HR+/HER2- Metastatic Breast Cancer. [PDF]
Cancers (Basel)Cazzaniga ME +5 more
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Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract BACKGROUND Individuals with Alzheimer's disease (AD) dementia can be subgrouped based on cognitive performance at diagnosis. We compared neuropathology across cognitively defined AD subgroups in the Adult Changes in Thought study. METHODS Scores for memory, executive functioning, language, and visuospatial abilities were derived from the ...
Caitlin S. Latimer +12 more
wiley +1 more source
Inhibition of CDK/Cyclin-phospho-Rb signaling by amebaciclib may have an antitumor effect against uterine leiomyosarcoma. [PDF]
Signal Transduct Target TherHayashi T, Muto M, Konishi I.
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CCNE1: A Cell Cycle Regulator That Influences Tumor Progression
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Liang Yan +6 more
wiley +1 more source
CDK7, CDK9, or CDK11 inhibition reduces neutrophil-driven inflammation and tissue damage in experimental autoimmune models. [PDF]
Cell Commun SignalSchlotfeldt M +21 more
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