Results 181 to 190 of about 118,570 (219)

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, Volume 117, Issue 4, Page 885-895, April 2026.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source

Integration of ear and hearing care services in low- and middle-income health systems: a systematic review and qualitative synthesis. [PDF]

Glob Health Action
de Kock C, Gilson L.
europepmc   +1 more source

Targeting BCL‐xL in Myeloid Malignancies: From Inhibitors to PROTAC

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Restoring apoptosis in malignant cells represents a central goal of anticancer therapy. Tumour cells often escape cell death by overexpressing anti‐apoptotic members of the BCL‐2 protein family, particularly BCL‐2, BCL‐xL, and MCL1. These proteins inhibit the intrinsic mitochondrial apoptotic pathway through intricate interactions with pro ...
Daniela Cilloni, Alessandro Ferrando, Francesco Frassoni   +2 more
wiley   +1 more source

Cell cycle in plant development and reprogramming. [PDF]

Development
Lee LR, Torii KU.
europepmc   +1 more source

Non‐innocent solvents in meteorite extractions: Evidence for artifact formation

Meteoritics &Planetary Science, Volume 61, Issue 4, Page 706-719, April 2026.
Abstract Solvent extraction is a cornerstone of meteoritic organic and inorganic chemistry, yet the assumption that common solvents act as chemically inert media is becoming increasingly untenable. This study reports that low‐molecular‐weight alcohols, particularly methanol and ethanol, are “non‐innocent” solvents when used to extract soluble sulfur ...
N. Randazzo, R. W. Hilts, R. M. Whittal, B. Reiz, V. Olan‐Rubio, C. D. K. Herd, I. H. Krouse   +6 more
wiley   +1 more source

Focal Adhesion and Cancer Cell Cycle-Associated Resistance. [PDF]

ACS Omega
Ruksha TG, Palkina NV, Lapkina EZ, Liu K.   +3 more
europepmc   +1 more source

Single Cell Analysis Reveals the Presence of Novel Intermediate Cells in Both Mice and Patients With Severe MASLD

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Schematic overview of the experimental workflow combining single‐cell RNA sequencing and spatial proteomics in a murine model of MASLD. Tissues were isolated, dissociated, and processed for single‐cell transcriptomic profiling to identify distinct cellular clusters and define cell‐type–specific gene expression signatures. Computational analysis enabled
Marica Meroni, Paride Pelucchi, Erika Paolini, Miriam Longo, Ada Sula, Michele Battistin, Alice Chiodi, Deborah Mattinzoli, Masami Ikehata, Elena Trombetta, Daniele Dondossola, Alessandra Mezzelani, Gianluca Martino Tartaglia, Giuseppe Castellano, Anna Ludovica Fracanzani, Flora Peyvandi, Stefano Gatti, Ettore Mosca, Paola Dongiovanni   +18 more
wiley   +1 more source

Inactivation of CDK4/6, CDK2, and ERK in G1-phase triggers differentiation commitment. [PDF]

Commun Biol
Sharma S, Berger H, Meyer T, Teruel MN.
europepmc   +1 more source

Real-world patterns of post-progression treatment and outcomes in patients with HR+/HER2- advanced breast cancer treated with CDK4/6 inhibitors. [PDF]

Oncologist
Torrisi R, Giugliano F, Giordano L, Saltalamacchia G, Jacobs F, Carnevale Schianca A, Milano M, Bianco N, Sangalli CA, De Sanctis R, Masci G, Curigliano G, Santoro A, Munzone E.   +13 more
europepmc   +1 more source

Efficacy of everolimus in patients with hormone receptor positive, HER2 negative, metastatic breast cancer pretreated with CDK4/6 inhibitors. [PDF]

Breast Cancer Res
Dutheil J, Pereira V, Boisson C, Mansi L, Paillard MJ, Bazan F, Chaigneau L, Dobi E, Viot J, Meynard G, Goujon M, Dalens L, Dubourd C, Marchi S, Meneveau N, Vernerey D, Adotévi O, Meurisse A, Curtit E.   +18 more
europepmc   +1 more source