Results 181 to 190 of about 72,294 (253)

Chemical Diversity and Biological Significance of Sesquiterpene Lactones: From Biosynthesis to Anticancer Mechanisms

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari, Ragini Yadav, Mayank Kashyap, Shreyans K. Jain   +3 more
wiley   +1 more source

Feasibility and Acceptability of Perioperative Application of Biofeedback-Based Virtual Reality vs Control for Pain and Anxiety in Children and Adolescents Undergoing Surgery: Pilot Randomized Controlled Trial. [PDF]

J Med Internet Res
Lin AM, Rachwal B, Asti L, Orgil Z, Santiago I, Ding L, Kashikar-Zuck S, King CD, Williams SE, Black WR, Minneci PC, Olbrecht VA.   +11 more
europepmc   +1 more source

Phytochemistry, Pharmacological Potential, and Future Prospects of Abietane‐Type Diterpenoids From Salvia rosmarinus

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
The review delves into the findings on abietane diterpenes from Salvia rosmarinus. It comprises the phytochemistry, biological activities, biosynthesis, degradation studies, semisynthesis, and pharmacokinetic studies of these compounds. The potential of these compounds for future development has also been highlighted.
Rida Siddiqui, Vipin Singh, Kapil Dev
wiley   +1 more source

Whole-Genome Analysis of the Cell Cycle Regulators in Soybean: Evolution, Expansion, and Functional Implications. [PDF]

Biology (Basel)
Jia Q, Shi J, Wang R, He X, Guo B, Zhu G, Song L.   +6 more
europepmc   +1 more source

Imine Reductase‐Mediated Regio‐ and Stereoselective Reductive Amination of Diamines

ChemCatChem, Volume 18, Issue 19, 14 October 2026.
Imine reductases (IREDs) have been employed as biocatalysts for the regioselective modification of diamines via reductive amination. The use of racemic diamines resulted in both regio‐ and enantio‐selective reductive amination via kinetic resolution. The application of this methodology has been demonstrated on a preparative scale by the synthesis of a ...
Arnau Rué Casamajo, Yuqi Yu, Lucian Pirvu, Christian Schnepel, Simon J. Charnock, Francesco Falcioni, Martin A. Hayes, Nicholas J. Turner   +7 more
wiley   +1 more source

Targeting Menin in T-lineage Acute Lymphoblastic Leukemia. [PDF]

Mol Cancer Ther
Shimamoto K, Karaoglu DA, Arnold O, Dhar A, Chan Z, Giordano G, Cheng JX, Youshanlouei HR, Patel AA, DuVall AS, Drazer MW, Kessler L, Burrows F, Odenike O, Thirman MJ, Stock W, Saygin C.   +16 more
europepmc   +1 more source

Race and Socioeconomic Status are Predictors of Survival in Patients With Metastatic Bone Disease Secondary to Breast Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background With implementation of early detection screening methods and advances in medical treatment, there have been improvement in outcomes for patients with breast cancer. Despite this, studies have suggested potential differences in outcomes amongst various racial and ethnic groups.
Ashley Castan, Rosamaria Dias, Amog Mysore, David Herz, Katie Gotoff, Yazan Kadkoy, Kathleen Beebe, Joseph Benevenia, Joseph Ippolito   +8 more
wiley   +1 more source

Stem cell killer: cyclin-dependent kinase inhibitor KRP6 eliminates DNA-damaged stem cells. [PDF]

Plant J
Mooney BC.
europepmc   +1 more source

Advancing Blue‐Light Photoactivatable TAM Kinase Inhibitors for Cancer Treatment: Challenges in Using π‐Extended Coumarins as Photocleavable Protecting Groups

ChemPhotoChem, Volume 10, Issue 10, October 2026.
Promise and obstacles of π‐extended coumarin as photolabile protecting groups for blue‐light photoactivatable TAM kinase inhibitors. We developed a series of photocleavable TAM kinase inhibitors that incorporate various π‐extended coumarins as photoremovable groups, enabling blue‐light activation.
Sébastien Billotte, Gaëlle Fontaine, Frédéric Bolze, Alexandre Specht, Sophie Bombard, Sandrine Piguel   +5 more
wiley   +1 more source

Integrated CDK4/6 inhibitor resistance and primary-metastatic discordance in hormone receptor-positive/HER2-negative metastatic breast cancer: a translational framework focused on invasive ductal carcinoma with gastric metastasis. [PDF]

Front Oncol
Cheng M, Wang D, Lin Y, Wu C, Hong R, Zhang J, Li J.   +6 more
europepmc   +1 more source