Results 201 to 210 of about 72,294 (253)

Dual phosphoregulatory mechanisms of condensin I revealed by biochemical reconstitution. [PDF]

PNAS Nexus
Shintomi K, Tane S, Masahara-Negishi Y, Hirano T.   +3 more
europepmc   +1 more source

Protective Effects of Nongxiang‐Type Tieguanyin on the Liver of D‐Galactose‐Induced Aging C57BL/6 Mice via the NF‐κB Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Mechanistic diagram of the hepatoprotective effect of Tgy‐N on D‐gal‐induced senescent C57BL/6 mice (“→” indicates activation, and “⊣” indicates inhibition). ABSTRACT This research aimed to investigate the hepatoprotective and anti‐senescence effects of Nongxiang‐type Tieguanyin (Tgy‐N) on D‐galactose (D‐gal)‐induced aging C57BL/6 mice and to elucidate
Weihong Chen, Mingmei Li, Lingxiao Ye, Dongqin Huang, Jianjia Xiao, Yuchao Sang, Zizhen Wang, Jiehong Yang, Chengyong He, Jiabin Chen, Zhenghong Zuo, Xintan Chen   +11 more
wiley   +1 more source

MNAT1 in gastrointestinal cancers: mechanistic insights and therapeutic strategies-a narrative review. [PDF]

J Gastrointest Oncol
Zhang Y, Hu A, Wen C, Yang X, Wang X, Zheng S.   +5 more
europepmc   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, Volume 5, Issue 5, Page 495-513, October 2026.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Author Correction: The CDK Pho85 inhibits Whi7 Start repressor to promote cell cycle entry in budding yeast. [PDF]

EMBO Rep
Ros-Carrero C, Spiridon-Bodi M, Igual JC, Gomar-Alba M.   +3 more
europepmc   +1 more source

Targeting the PI3K/Akt Signaling Pathway: A Promising Therapeutic Strategy to Reduce Cancer Mortality and Overcome Chemoresistance

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims The phosphatidylinositol 3‐kinase (PI3K)/Akt signaling pathway is a central regulator of cellular properties that are essential for cancer progression, including cellular growth, survival, metabolism, and angiogenesis. Dysregulated PI3K/Akt signaling, often caused by genetic alterations in PIK3CA, loss of PTEN, or the ...
Md Mohiuddin
wiley   +1 more source

Power and Loneliness: The Role of Cultural Values

International Journal of Psychology, Volume 61, Issue 5, October 2026.
ABSTRACT Loneliness–the subjective, unpleasant state of social disconnectedness–has long been recognised as a public health concern and is estimated to affect 16% of the global population. There is some evidence for the social benefits of power in protecting one from loneliness, but theories and evidence remain inconsistent.
Hodar Lam, Zhaoyang Xie, Tong Xu, Emmanuel Affum‐Osei, Sharon G. Goto, Rong Wang, June Chun Yeung, Darius K‐S. Chan   +7 more
wiley   +1 more source

Proteolysis Targeting Chimera (PROTAC) Linkerology Enhances the CDK-Degradation Selectivity Profile of a Multi-CDK Inhibitor: Discovery of Potent, Anti-Leukemic CDK9 Degraders. [PDF]

ACS Pharmacol Transl Sci
Chan AM, Eberly C, Goodis CC, Nordquist EB, Weldemariam M, Carter-Cooper BA, Pogash S, Lapidus R, Kane MA, MacKerell AD, Civin CI, Fletcher S.   +11 more
europepmc   +1 more source

Resurgence of Sexually Transmitted Hepatitis C Virus Infection in Men Who Have Sex With Men Living With HIV

Journal of Medical Virology, Volume 98, Issue 10, October 2026.
ABSTRACT In 2023–2025, HCV transmission in men who have sex with men (MSM) living with HIV in Hong Kong resurged. This study aims to assess the epidemiologic patterns between 2011 and 2025. Among 288 MSM with sexually acquired HCV infection, 73% were diagnosed at least 12 months after HIV diagnosis, and 98% had ever achieved HIV viral load suppression.
Shui‐Shan Lee, Denise Pui‐Chung Chan, Bonnie Chun‐Kwan Wong, Danny King Fai Cheung, Ngai Sze Wong   +4 more
wiley   +1 more source