Comparative Functional Effects of Abemaciclib and Arcyriaflavin A in <i>MYCN</i>-Amplified and Non-Amplified Neuroblastoma Cells: An Exploratory Transcriptomic Study. [PDF]
Int J Mol SciÇerçi B +4 more
europepmc +1 more source
Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms
Medicinal Research Reviews, Volume 46, Issue 6, Page 1735-1752, November 2026.ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino +3 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley +1 more source
The non-canonical CDK2 activator SPY1 uses separable mechanisms to activate phosphorylated and unphosphorylated CDK2. [PDF]
Biochem JFawcett LP, Levinson NM.
europepmc +1 more source
Nucleolin Alterations and ROS Production Associate With Sensitivity of AML Cells to Venetoclax
The FASEB Journal, Volume 40, Issue 19, 15 October 2026.Venetoclax‐induced Bcl‐2 inhibition corresponds with Mcl‐1 attenuation and decrease of Nucleolin (NCL) level and activity in sensitive cells. Simultaneously, distinct cell subpopulations with opposite mitochondrial (CellROX label, magenta) and cellular (H2DCFDA stain, green) ROS occur, and the H2DCFDA‐positive population shows markers of early ...
Kateřina Wolfová +2 more
wiley +1 more source
Targeting CDK-2 With Novel Indole-Pyrazole Hybrids: Discovery of Potent Anticancer Agents Supported by Mechanistic and In Silico Studies. [PDF]
Drug Dev ResEldehna WM +10 more
europepmc +1 more source
WHI3 Regulation of CDK in S. cerevisiae.
, 2018 There are many diseases associated with malfunc4ons in the cell cycle. For instance, aneuploidy—when daughter cells have the abnormal number of chromosomes—results from improper cell division.
Lacefield, Soni +2 more
core
ChemMedChem, Volume 21, Issue 19, 14 October 2026.A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain +6 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, Volume 20, Issue 10, Page 2490-2509, October 2026.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
uORF-mediated translational control of CAK and Cdk activation in response to low nutrients in yeast. [PDF]
EMBO RepBlank HM +5 more
europepmc +1 more source