Results 161 to 170 of about 57,313 (205)

The cyclin‐dependent kinase inhibitor KIP‐RELATED PROTEIN 6 promotes stem cell death upon DNA damage in Arabidopsis roots

The Plant Journal, Volume 126, Issue 5, June 2026.
SUMMARY Maintenance of genome integrity is essential for plant growth and survival. Plants have evolved specialised DNA damage responses that coordinate DNA repair, cell cycle arrest and stem cell‐specific cell death. However, the mechanism through which damaged stem cells are selectively eliminated remains unclear.
Toshiki Wada, Ayako N. Sakamoto, Masaaki Umeda, Naoki Takahashi   +3 more
wiley   +1 more source

Considerations for establishing occupational exposure limits for small molecule kinase inhibitors in drug development. [PDF]

Front Toxicol
Nicholas T, Morinello E, Moudgal C, Beaulieu A, Graham J.   +4 more
europepmc   +1 more source

Intravesical Delivery of P21 mRNA–Loaded Lipid Nanoparticles as a Tumor Suppressor Replacement Therapy for Bladder Cancer

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Intravesical delivery of p21 mRNA‐loaded lipid nanoparticles (p21‐LNP) restores the tumor suppressor p21 in bladder cancer. Localized p21 expression directly induces cell cycle arrest, DNA damage and apoptosis, and ultimately inhibits orthotopic tumor growth with minimal systemic distribution and favorable safety.
Jie Zeng, Ziyi Cao, Chenghe Wang, Yingjie Xu   +3 more
wiley   +1 more source

Identification and functional evaluation of cyclin-dependent kinase genes reveals that CDKB1;1 and CDKB2;2 contribute to the balance of mitosis and endoreduplication in Medicago truncatula nodule. [PDF]

BMC Plant Biol
Wang R, Pan H.
europepmc   +1 more source

Congenital Knee Dislocation: A Case Report. [PDF]

Clin Case Rep
Castro-Lara M, Palencia Sagastume GE, Gaitán-Zambrano K, Baca Garcia CH, Palencia Sagastume JA, Maradiaga J.   +5 more
europepmc   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

PROTACs for Collateral Degradation: Is It Time to Back Up the Bus? [PDF]

ACS Med Chem Lett
Gao ZG, Burgess K.
europepmc   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Evaluation of New Coumarins for Anti-Cancer Activity in HL-60 Cell Line Supported by Molecular Docking, MD Simulation, and Binding Free Energy Calculations. [PDF]

Onco Targets Ther
Humayun N, Rabbi F, Sohail M, Khan A, Zeb A, Nisar A, Rahim A, Shao C, Wang S, Younas A.   +9 more
europepmc   +1 more source

Chemical Modification of 2,6,9-Trisubstituted Purine CDK Inhibitors: <i>tert</i>-Butylation at <i>N</i>7/<i>N</i>9 and Access to 2,6,7-Trisubstituted Analogs. [PDF]

ACS Omega
Valenta M, Stýskala J.
europepmc   +1 more source