Results 141 to 150 of about 72,294 (253)

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1

The FEBS Journal, EarlyView.
In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández, Estefany D. Guerrero‐Molina, Ulises Martínez‐Ortega, Aurora Lara‐Núñez, Jorge M. Vázquez‐Ramos   +4 more
wiley   +1 more source

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

The FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash, Olivier Haccard, Zhen Li, Nicolas Pollet, Kathrin Marheineke   +4 more
wiley   +1 more source

Phosphorylation of BigH1 regulates its expression pattern and promotes embryonic development

The FEBS Journal, EarlyView.
Phosphorylation is a key regulator of the linker histone variant BigH1 during Drosophila embryogenesis. We reveal that N‐terminal phosphorylation promotes the timely removal of BigH1 from chromatin. In contrast, C‐terminal phosphorylation supports early nuclear divisions and embryonic viability.
Ramóna Pék, Aladár Pettkó‐Szandtner, Anikó Szabó, Balázs Vedelek, Bence György Gombás, Zoltán Villányi, Péter Vilmos, Imre Miklós Boros, László Henn, Gyula Timinszky   +9 more
wiley   +1 more source

Cyclin/cdk complexes: their involvement in cell cycle progression and mitotic division

, 2015
DNA replication and mitosis are dependent on the activity of cyclin-dependent protein kinase (CDK) enzymes, which are heterodimers of a catalytic subunit with a cyclin subunit.
Moore, R., John, Peter Crook, Mews, M
core  

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

UK recommendations for Ki‐67 immunohistochemical staining and interpretation in breast cancer

Histopathology, EarlyView.
Where possible, a validated digital imaging system should be utilized. If this is not available, then intermediate scores (5%–30%) should be thoroughly assessed using the Ki‐67 International Working Group guidance. Difficult cases should be double scored.
Abeer M Shaaban, Andrew Dodson, Emad Rakha, Ian Ellis, Daniel Rea, Cecily Quinn, Elena Provenzano, Sarah Pinder, on behalf of the UK National Coordinating Committee for Breast Pathology (NCCBP), Association of Breast Pathology (ABP) and the UK National External Quality Assessment Scheme for Immunohistochemistry and In Situ Hybridisation (UK NEQAS ICC & ISH)   +9 more
wiley   +1 more source

Prevalence and Characteristics of North American Indigenous Inflammatory Skin Disease: A Systematic Scoping Review

International Journal of Dermatology, EarlyView.
This scoping review synthesizes evidence on atopic dermatitis (AD), psoriasis, and hidradenitis suppurativa in North American Indigenous peoples across 49 studies and 63 clinical trials. Findings reveal consistently high disease burden in AD, marked underrepresentation in trials and guidelines, and five evidence‐based recommendations to advance ...
Rachel Asiniwasis, Jordanna Roesler, Amira Muftah, Aysha Lukmanji, McKenzie Van Eaton, Kavya Yatham, Erin Watson, Eric McMullen, Gregory Kost, Colton Jensen, Oluwatosin Odeshi, Anna Chacon, Dana Slape, Brittany Waller, Kelsey Hinther, Mamata Pandey, Carolyn Jack, Derek K. Chu   +17 more
wiley   +1 more source

Excess endopolyploidy associated with cellular defects in neo‐autotetraploid Arabidopsis arenosa is in part corrected by a naturally evolved allele of CYCD3;2

New Phytologist, EarlyView.
Ploidy level distributions and endoreduplication profiles in diploid and tetraploid Arabidopsis arenosa. Summary Endopolyploidy (within‐organism polyploidy) is an often‐beneficial aspect of development. But polyploids, which have a higher baseline genome content, have been reported to have less endoreduplication than diploid relatives. Why has remained
Anis Meschichi, Marinela Dukić, Lars C. Schmid, Andreas L. Bachmann, Tadeas J. Priklopil, Hui San Tan, Kirsten Bomblies   +6 more
wiley   +1 more source

An Intronic Structural Variant in GhEBS1 Drives Cotton Fruit Size Divergence by Modulating Chromatin Accessibility and Gene Expression

Plant Biotechnology Journal, EarlyView.
ABSTRACT Fruit size is not only a crucial fitness trait in plant evolution but also an important agronomic target in crop domestication and improvement, yet its regulatory mechanisms remain poorly characterized. Here, we identified an F‐box E3 ubiquitin ligase gene, GhEBS1 (ENLARGED BOLL SIZE 1), as a positive regulator of cotton boll size via map ...
Furong Wang, Yu Chen, Zhangqiang Song, Ao Pan, Xuehan Huo, Jingxia Zhang, Yang Gao, Zhecheng Yuan, Mengchen Zhu, Mingyang Lei, Pei Zhang, Juan Zhou, Zhaohai Du, Shengli Wang, Jiaojiao Feng, Minghui Feng, Chuanban Li, Shoupu He, Tianzhen Zhang, Jun Zhang   +19 more
wiley   +1 more source