Results 81 to 90 of about 57,522 (220)

Diflubenzuron Caused Mitochondrial Dysfunction, Ca2+ Homeostasis Disruption, and Intrinsic Apoptosis in Trophoblastic Cells

Environmental Toxicology, EarlyView.
ABSTRACT Diflubenzuron is used as an insect growth inhibitor, and its potential risk to human health was raised owing to the possibility of environmental residues and human exposure. This study aimed to investigate the toxic mechanism of diflubenzuron on trophoblastic cells such as HTR8/SVneo and JEG‐3 cells. We investigated mitochondrial function, Ca2+
Miji Kim, Wonhyoung Park, Whasun Lim, Gwonhwa Song, Sunwoo Park   +4 more
wiley   +1 more source

Congenital dislocation of the knee: A protocol for management based on degree of knee flexion

Journal of Children's Orthopaedics, 2011
Purpose Congenital dislocation of the knee (CDK) is a relatively rare condition. It may occur as an isolated deformity, it may be associated with musculoskeletal anomalies such as developmental dysplasia of the hip and clubfoot, or it may occur as part ...
Tarek Hassan Abdelaziz, Shady Samir
doaj   +1 more source

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

Palbociclib in the Treatment of HR+/ HER2‐ Advanced or Metastatic Breast Cancer in Australia: A Real‐World Retrospective Analysis

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This study investigated the real‐world use of CDK4/6 inhibitors in Australian patients with HR+/HER2‐ advanced or metastatic breast cancer, providing data on patient demographics, treatment patterns, and outcomes with palbociclib. ABSTRACT Background There is limited real‐world data on the use of CDK4/6 inhibitors in Australian patients with HR+/HER2 ...
Louise Nott, Eugene Moylan, Maree Colosimo, Giles Stratton, Thomas Chiu, Mahsa H. Kouhkamari, Maureen Hitschfeld, Jessica Michie, Richard De Boer   +8 more
wiley   +1 more source

The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.

PLoS Genetics, 2013
CtIP plays an important role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair and interacts with Nbs1 and BRCA1, which are linked to Nijmegen breakage syndrome (NBS) and familial breast cancer, respectively.
Hailong Wang, Linda Z Shi, Catherine C L Wong, Xuemei Han, Patty Yi-Hwa Hwang, Lan N Truong, Qingyuan Zhu, Zhengping Shao, David J Chen, Michael W Berns, John R Yates, Longchuan Chen, Xiaohua Wu   +12 more
doaj   +1 more source

Global Variation in Timing of Allergenic Food Introduction for Food Allergy Prevention: An International Survey of Healthcare Professionals

Allergy, EarlyView.
This study examines the current state of food allergy prevention guideline implementation worldwide, identifying key variables that may explain the observed global variation. Among 731 healthcare professionals across 80 countries, geography and clinical specialty independently drove allergenic food introduction practices, creating an 8.5‐month practice
Agnes Sze‐yin Leung, Elizabeth Huiwen Tham, Kiwako Yamamoto‐Hanada, Derek K. Chu, Matthew Norris, Daria Levina, Daniel Munblit, Lamia Dahdah, Luciana Kase Tanno, Carmen Riggioni, Elsy M. Navarrete‐Rodriguez, Michael E. Levin, Thulja Trikamjee, William Guo, Chun Tong Lei, Chun Pong Lau, Supinda Bunyavanich, Nikolaos G. Papadopoulos, Adnan Custovic, Christina West, Gary Wing‐kin Wong   +20 more
wiley   +1 more source

CELL CYCLE REGULATOR: CYCLIN DEPENDENT KINASE 10 AS POTENTIAL TARGET IN CANCER

Pakistan Journal of Medicine and Dentistry, 2019
Cell cycle progression through each phase is regulated by series of kinase family, the cyclin dependent kinases (CDK). To understand this CDK machinery that controls normal cell cycles, by forming CDK/cyclin complexes thus assisting the identification ...
Muhammad Fazal Hussain Qureshi, Mahira Lakhani, Muzna Shah, Shamim Mushtaq   +3 more
doaj  

Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination

Allergy, EarlyView.
We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera, Benjamin Schwarz, Brittany Dulek, Ian S. LaCroix, Min Li, Lindsay Chatman, Muhammad B. Khalid, Ellen Zektser, Karen Laky, Stella Hartono, Eric Bohrnsen, Cole D. Kimzey, Eric Chu, Roa Harb, Pamela A. Frischmeyer‐Guerrerio   +14 more
wiley   +1 more source

Correlations between the levels of vitamin D, parathormone, calcium, blood phosphates in patients with chronic disease of the kidneys untreated with replacement renal therapy

Терапевтический архив, 2009
Aim. To characterize correlations between the levels of vitamin D, parathormone, calcium, blood phosphates in patients with different stages of chronic disease of the kidney (CDK) given no therapy replacing renal function (TRRF).
Aleksey Vladimirovich Smirnov, Mikhail Mikhaylovich Volkov, Ol'ga Vladimirovna Galkina, Aleksandr Anatol'evich Zhloba, Vladimir Leonidovich Emanuel', A V Smirnov, M M Volkov, O V Galkina, A A Zhloba, V L Emanel   +9 more
doaj  

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source