Results 81 to 90 of about 72,294 (253)
BMC Genomics, 2023 as one of the oldest cultivated crops in the world, quinoa has been widely valued for its rich nutritional value and green health. In this study, 22 CDK genes (CqCDK01-CqCDK22) were identified from quinoa genome using bioinformatics method. The number of
Wangtian Wang, Wenyu Liu, Baoqiang Wang
doaj +1 more source
CRISPR editing and transgenics demonstrate RPM-1 restricts CDK-5 kinase activity.
, 2022 A) Protein sequence alignment showing two conserved CDK-5 residues (red) mutated to inactivate kinase activity. Workflow for evaluating CDK-5 kinase activity using CRISPR/Cas9 editing or transgenic engineering.
Brock Grill (561446) +5 more
core +1 more source
Advanced Science, EarlyView.Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song +8 more
wiley +1 more source
BMC Ophthalmology, 2021 Background Investigation of the prevalence of climatic droplet keratopathy (CDK) in Tacheng, Xinjiang, China. Methods A total of 1030 participants, in their 40s or older, from the Kazakh ethnic group in Tacheng, were randomly sampled by stratification ...
Zhixiang Hua +7 more
doaj +1 more source
, 2013 Cells coordinate spindle formation with DNA repair and morphological modifications to chromosomes prior to their segregation to prevent cell division with damaged chromosomes.
Philip W. Jordan (265255) +23 more
core +1 more source
The global dynamics of CDK substrate phosphorylation in a simplified CDK network [PDF]
, 2016 Cyclin-CDK complexes initiate S-phase and mitosis, but how these events are temporally separated is not fully understood. In S. pombe a single Cyclin-CDK is sufficient to order the cell cycle. Understanding how and when CDK substrates are phosphorylated,
Swaffer, MP
core
Animal Research and One Health, EarlyView.Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue +10 more
wiley +1 more source
S-faasi CDK spetsiifilisus rakutsükli fosforüleerimise ajastamises [PDF]
, 2020 Cell proliferation is an essential process in all organisms. Through a series of growth and division, the cell passes its genetic material to the next generation of cells.
Matiyevskaya, Frida
core
Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
British Journal of Clinical Pharmacology, EarlyView.Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra +8 more
wiley +1 more source
The present invention relates to novel CDK degraders of general formula (I). These novel compounds are useful in the treatment of diseases that are associated with CDK activity, such as cancer and ...
Konstantinidou, Markella +2 more
core +4 more sources