Results 81 to 90 of about 118,570 (219)

Discovery of a Novel γ‐Glutamylcyclotransferase Inhibitor Plumbagin by Luminescence‐Based High‐Throughput Screening

Cancer Science, EarlyView.
A cell‐based high‐throughput screening system utilizing the luminescent probe LISA‐103 was developed to monitor γ‐glutamylcyclotransferase (GGCT) activity in cancer cells. Through this assay, plumbagin was identified as a novel GGCT inhibitor that induces cell cycle arrest and suppresses cancer cell growth. ABSTRACT γ‐Glutamylcyclotransferase (GGCT) is
Keiko Taniguchi, Yukie Nohara, Mano Horinaka, Kozue Nose, Masaya Mori, Hiromi Ii, Hiroko Kawakami, Kazuto Yano, Susumu Nakata, Taku Yoshiya, Toshiyuki Sakai   +10 more
wiley   +1 more source

‘What’ and ‘How’ to Measure in Allergy and Clinical Immunology: A Systematic Review of Core Outcome Sets and Outcome Harmonisation Processes

Clinical &Experimental Allergy, EarlyView.
This systematic review maps core outcome sets and harmonisation efforts in allergy and clinical immunology. Despite shared priorities such as quality of life and symptoms, substantial gaps and methodological inconsistencies remain, underscoring the need for broader coverage and standardised outcome measurement to improve comparability and clinical ...
Anastasia Demidova, Nata Kiknavelidze, Kristine Purtskhvanidze, Elvina Alieva, Mehrshad Ebrahimnejad, Svetlana Konchina, Azaliya Nurmeeva, Igor Matkovskii, Elmira Elmurzaeva, Siuzanna Davtian, Natalia Degtyareva, Karl Philipp Drewitz, Alan Asmanov, Nikolina Banjanin, Erna Botjes, Pasquale Comberiati, Joana Costa, Derek K. Chu, Michelle M. Epstein, Lyudmila Fedorova, Audrey Dunn Galvin, Mattia Giovannini, Matthew Greenhawt, Kristina R. Jamalyan, Christina J. Jones, Ekaterina Khaleva, Rebecca C. Knibb, Yael A. Leshem, Douglas P. Mack, Isabel Mafra, Mary Jane Marchisotto, Dragan Mijakoski, Asel Nurtazina, Cevdet Özdemir, Diego Peroni, Jennifer L. P. Protudjer, Pablo Rodríguez Del Rio, Ann‐Marie Malby Schoos, Anita Fossaluzza Schopfer, Sasho Stoleski, Julia Upton, Willem van de Veen, Jon Genuneit, Robert J. Boyle, Christian Apfelbacher, Daniel Munblit   +45 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Molecular and cellular effects of the combined treatment with Camptothecin and Roscovitine in human lung and colon adenocarcinoma cells [PDF]

, 2008
De Mattia, Roberta
core   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

A multi‐centre retrospective review of the bronchoscopic management of upper tracheal stenosis: An Australian perspective

Internal Medicine Journal, EarlyView.
Abstract Background Upper tracheal stenosis (UTS) is a rare process with multiple causes and variable approaches to treatment. Australian data on management patterns are lacking and patient resources reflecting local practices are scarce. Aims To describe the management strategies of UTS over 12 years among three teaching hospitals in New South Wales ...
Nathan Harb, David K. E. Chan, Eugenie Dale, Tsu‐Hui (Hubert) Low, Tajalli Saghaie, Alvin J. Ing, Jonathan Williamson   +6 more
wiley   +1 more source

Complex Regulation of RETINOBLASTOMA‐RELATED's Interactions With E2Fs via Phosphorylation

Plant, Cell &Environment, EarlyView.
ABSTRACT Arabidopsis RETINOBLASTOMA‐RELATED (RBR) regulates cell proliferation by interacting with E2F transcription factors and DIMERISATION PARTNER, RB‐LIKE, E2F AND MULTI‐VULVAL CLASS B COMPLEX (DREAM) components. Although CDK‐CYCD phosphorylation is believed to affect RBR's E2F‐binding capacity, the precise phosphorylation events inhibiting RBR's ...
Aladár Pettkó‐Szandtner, Fruzsina Vadai‐Nagy, Magdolna Gombos, Attila Hlacs, Eszter Molnár, Annamária Marton, Csaba Vizler, Rasik Shiekh Bin Hamid, Péter Kaló, Attila Fehér, Zoltán Magyar   +10 more
wiley   +1 more source

CDK Literature #1

, 2007
For each CDK News I try to write up what CDK related literature has been published recently, but I failed to do so for the last two issues. In order to not postpone writing it up until close to the deadline, I will write up things here, so that I can copy-paste it later for CDK News.
openaire   +1 more source

Alleviation of photoaging‐associated MMP upregulation, prostanoid biosynthesis, and cell cycle arrest with titanium dioxide, zinc oxide, and inorganic‐only (ZnO + TiO2) sunscreens

Photochemistry and Photobiology, EarlyView.
Inorganic sunscreens containing the UV filters titanium dioxide (TiO2) and/or zinc oxide (ZnO) alleviated various biomarkers of photoaging in human dermal fibroblasts, at a gene and protein level. The study provides novel insights that observe the impact of inorganic photoprotection through the molecular biology of skin.
Neil Dominic T. Pangilinan, Mohammad Shalbaf, Aline Souza, Bhaven Chavan, Mark A. Birch‐Machin   +4 more
wiley   +1 more source

Comparative Response of Canine and Human Osteosarcoma Tumour Cell Lines to Molecularly Targeted Anticancer Agents at Clinically Relevant Exposures With Analysis of Genomic Biomarkers

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Osteosarcoma (OSA) is a primary bone tumour occurring in children but is also prevalent in large breed dogs. Canine OSA (cOSA) has long been viewed as analogous to human OSA (hOSA) with cOSA serving as a surrogate for development of therapeutic approaches to treat the rarer human form.
Daniel L. Gustafson, Kala A. Early, Maritza A. Morales, Klaudia A. Poplawski, Sunetra Das, Dawn L. Duval   +5 more
wiley   +1 more source