Results 61 to 70 of about 72,294 (253)

Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER [PDF]

, 2021
In budding yeast, synchronization of waves of mitotic cyclins that activate the Cdk1 kinase occur through Forkhead transcription factors. These molecules act as controllers of their sequential order and may account for the separation in time of ...
Matteo Barberis, Barberis, M., Barberis, Matteo   +2 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Use of Directories on CDK Programs in the Educational Process [PDF]

, 2021
В данной статье рассматривается вопрос составления и использования электронных справочников по CDK-программам в образовательный процесс. Рассматриваются причины использования и полезность их применения.This article discusses the issue of compiling and ...
Kortusov, A. V., Кортусов, А. В.   +1 more
core   +1 more source

Requirement of PP2A-B56Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/CSte9 during Pre-Start G1 in S. pombe

iScience, 2020
Summary: Exit from the cell cycle during the establishment of quiescence and upon cell differentiation requires the sustained inactivation of CDK complexes.
Vilte Stonyte, Ruth Martín, Dario Segura-Peña, Nikolina Sekulić, Sandra Lopez-Aviles   +4 more
doaj   +1 more source

Study on the interaction preference between CYCD subclass and CDK family members at the poplar genome level

Scientific Reports, 2022
Cyclin-dependent kinases (CDKs) control the progression of the cell cycle. D-type cyclin (CYCD) is generally believed to form a complex with CDK and control the G1/S transition.
Chengcheng He, Jinghui Liang, Zhaoqun Wu, Xianglin Zhuge, Nan Xu, Hailing Yang   +5 more
doaj   +1 more source

Supplementary Data from Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase Catastrophe

, 2010
Supplementary Data from Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase ...
Fabrizio Galimberti (14902125), Vincent Memoli (3521477), Hua Li (46469), Jeff Settleman (383251), Duane A. Compton (14807480), Xi Liu (142824), Ethan Dmitrovsky (3230), Simon R. Green (5006501), James DiRenzo (118411), Sreenath V. Sharma (14885219), Sarah L. Thompson (14933456), Patricia Greninger (5540831)   +11 more
core   +1 more source

cdk/cdk: CDK 2.7

, 2022
Log4j 2.17.1 JNA-INCHI Reorgnaize Maven Modules Please use v2.7.
John Mayfield, Syed Asad Rahman, Klas Jönsson, Lyle Burgoon, Yap Chun Wei, Arvid Berg, Danny Katzel, Alex Clark, Oliver Stueker, Tomáš Pluskal, Rajarshi Guha, kaibioinfo, Daniel Szisz, Ralf Stephan, Dmitry Katsubo, Eric Bach, ficolas2, Xavier Linn, Michael Wenk, Krishna Dole, Nina Jeliazkova, AndyHowlettGitHub, Cyrus Harmon, Jonathan Alvarsson, Nikolay Kochev, gilleain torrance, Kazuya Ujihara, Saulius Gražulis, Mark J. Williamson, Egon Willighagen   +29 more
core   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Lineage-specific CDK activity dynamics characterize early mammalian development

Cell Reports
Summary: Cyclin-dependent kinases (CDKs) regulate proliferation dynamics and cell fate in response to extracellular inputs. It remains largely unknown how CDK activity fluctuates and influences cell commitment during early mammalian development. Here, we
Bechara Saykali, Andy D. Tran, James A. Cornwell, Matthew A. Caldwell, Paniz Rezvan Sangsari, Nicole Y. Morgan, Michael J. Kruhlak, Steven D. Cappell, Sergio Ruiz   +8 more
doaj   +1 more source

CDK activity provides temporal and quantitative cues for organizing genome duplication. [PDF]

PLoS Genetics, 2018
In eukaryotes, the spatial and temporal organization of genome duplication gives rise to distinctive profiles of replication origin usage along the chromosomes.
Anthony Perrot, Christopher Lee Millington, Blanca Gómez-Escoda, Diane Schausi-Tiffoche, Pei-Yun Jenny Wu   +4 more
doaj   +1 more source