Results 41 to 50 of about 72,294 (253)

Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

iScience, 2023
Summary: Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints ...
Valdemaras Petrosius, Jan Benada, Olaf Nielsen, Erwin M. Schoof, Claus Storgaard Sørensen   +4 more
doaj   +1 more source

Structural insights into the functional diversity of the CDK–cyclin family [PDF]

Open Biology, 2018
Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism
Daniel J. Wood, Jane A. Endicott
doaj   +1 more source

cdk: CDK Release 1.5.11

, 2015
<p><a href="https://github.com/cdk/cdk/wiki/1.5.10-Release-Notes">https://github.com/cdk/cdk/wiki/1.5.11-Release-Notes</a></p ...
LuisFF, Syed Asad Rahman, Klas Jönsson, Yap Chun Wei, Arvid Berg, onkarshinde, zachcp, John May, Oliver Stueker, Uli Köhler, Miguel Correa, Carl Mäsak, ngn, Tomáš Pluskal, Rajarshi Guha, Daniel Szisz, Ralf Stephan, Dmitry Katsubo, PeterOdeus, rafeli, aclarkxyz, AndyHowlettGitHub, Cyrus Harmon, Jonathan Alvarsson, gilleain torrance, Mark Williamson, Stephan Beisken, Egon Willighagen, sambitgaan, mbv31602   +29 more
core   +1 more source

cdk: CDK Release 1.5.10

, 2014
<p><a href="https://github.com/cdk/cdk/wiki/1.5.10-Release-Notes">https://github.com/cdk/cdk/wiki/1.5.10-Release-Notes</a></p ...
LuisFF, Syed Asad Rahman, Yap Chun Wei, Arvid Berg, onkarshinde, John May, Oliver Stueker, Uli Köhler, Carl Mäsak, ngn, Rajarshi Guha, Daniel Szisz, Ralf Stephan, Dmitry Katsubo, KlasJoensson, PeterOdeus, rafeli, tomas-pluskal, aclarkxyz, CoderX, AndyHowlettGitHub, Cyrus Harmon, Jonathan Alvarsson, gilleain torrance, Mark Williamson, Stephan Beisken, Ola Spjuth, Egon Willighagen, sambitgaan, mbv31602   +29 more
core   +1 more source

cdk/cdk: CDK 2.2

, 2018
<p><a href="https://github.com/cdk/cdk/wiki/2.2-Release-Notes">2.2 Release Notes</a></p ...
John Mayfield, Syed Asad Rahman, Klas Jönsson, Lyle Burgoon, Yap Chun Wei, Arvid Berg, Alex Clark, Oliver Stueker, Uli Köhler, Tomáš Pluskal, Rajarshi Guha, kaibioinfo, Daniel Szisz, Ralf Stephan, Dmitry Katsubo, Hirotomo Moriwaki, Eric Bach, Michael Wenk, Nina Jeliazkova, AndyHowlettGitHub, Cyrus Harmon, Jonathan Alvarsson, Nikolay Kochev, gilleain torrance, Kazuya Ujihara, Saulius Gražulis, Mark J. Williamson, Egon Willighagen, mbv31602, kdole   +29 more
core   +1 more source

Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch

Frontiers in Physiology, 2012
The G1/S transition is a crucial decision point in the cell cycle. At G1/S, there is an abrupt switch from a state of high CDK inhibitor (CKI) levels and low S-phase CDK activity to a state of high S-phase CDK activity and degraded CKI. In budding yeast,
Rainis eVenta, Ervin eValk, Mardo eKõivomägi, Mart eLoog   +3 more
doaj   +1 more source

cdk: CDK Release 1.5.13

, 2016
<p><a href="https://github.com/cdk/cdk/wiki/1.5.13-Release-Notes">1.5.13 Release Notes</a></p ...
LuisFF, Syed Asad Rahman, Klas Jönsson, Yap Chun Wei, Arvid Berg, Alex Clark, onkarshinde, zachcp, John May, Oliver Stueker, Uli Köhler, Carl Mäsak, Tomáš Pluskal, Rajarshi Guha, Daniel Szisz, Ralf Stephan, Dmitry Katsubo, PeterOdeus, rafeli, Nina Jeliazkova, AndyHowlettGitHub, Cyrus Harmon, Jonathan Alvarsson, gilleain torrance, Mark Williamson, Stephan Beisken, Egon Willighⓐgen, sambitgaan, mbv31602, kdole   +29 more
core   +1 more source

Capturing CDKs in action: Live-cell biosensors pioneer the new frontiers in cell cycle research

Cell Structure and Function
Cyclin-dependent kinases (CDKs) orchestrate cell cycle progression through precise temporal control of substrate phosphorylation. While traditional biochemical approaches and phosphoproteomics have provided valuable insights into CDK-mediated regulation,
Sachiya Nakashima, Aika Toyama, Hironori Sugiyama, Kazuhiro Aoki, Yuhei Goto   +4 more
doaj   +1 more source

Chronic Kidney Disease (CKD) Diagnosis using Machine Learning Methodology Classifications

Iraqi Journal for Computers and Informatics
Early diagnosis of kidney as well as pre-kidney disease is crucial for patients because it allows them to take control of their condition and could potentially avoid or delay more significant consequences that could lower their quality of life.
Ahmed Sami Jaddoa
doaj   +1 more source

A CDK activity buffer ensures mitotic completion.

, 2022
The eukaryotic cell cycle is driven by the activity of cyclin-dependent kinases (CDKs). CDK activity rises over 50-fold during the cell cycle, from a low level in G1 to a high level in mitosis.
Paul Nurse (156843), Theresa U Zeisner (11103171), James O Patterson (8230974), Souradeep Basu (8665260)   +3 more
core   +1 more source