Results 21 to 30 of about 57,313 (205)

Structural insights into the functional diversity of the CDK–cyclin family [PDF]

Open Biology, 2018
Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism
Daniel J. Wood, Jane A. Endicott
doaj   +1 more source

Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

iScience, 2023
Summary: Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints ...
Valdemaras Petrosius, Jan Benada, Olaf Nielsen, Erwin M. Schoof, Claus Storgaard Sørensen   +4 more
doaj   +1 more source

Genetic background and climatic droplet keratopathy incidence in a Mapuche population from Argentina. [PDF]

PLoS ONE, 2013
PURPOSE:To determine whether the incidence of and susceptibility to climatic droplet keratopathy (CDK), an acquired, often bilateral degenerative corneal disease, is influenced by the genetic background of the individuals who exhibit the disorder ...
Theodore G Schurr, Matthew C Dulik, Thamara A Cafaro, María F Suarez, Julio A Urrets-Zavalia, Horacio M Serra   +5 more
doaj   +1 more source

Capturing CDKs in action: Live-cell biosensors pioneer the new frontiers in cell cycle research

Cell Structure and Function
Cyclin-dependent kinases (CDKs) orchestrate cell cycle progression through precise temporal control of substrate phosphorylation. While traditional biochemical approaches and phosphoproteomics have provided valuable insights into CDK-mediated regulation,
Sachiya Nakashima, Aika Toyama, Hironori Sugiyama, Kazuhiro Aoki, Yuhei Goto   +4 more
doaj   +1 more source

Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch

Frontiers in Physiology, 2012
The G1/S transition is a crucial decision point in the cell cycle. At G1/S, there is an abrupt switch from a state of high CDK inhibitor (CKI) levels and low S-phase CDK activity to a state of high S-phase CDK activity and degraded CKI. In budding yeast,
Rainis eVenta, Ervin eValk, Mardo eKõivomägi, Mart eLoog   +3 more
doaj   +1 more source

Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells. [PDF]

PLoS Genetics, 2011
Cell proliferation and differentiation are regulated in a highly coordinated and inverse manner during development and tissue homeostasis. Terminal differentiation usually coincides with cell cycle exit and is thought to engage stable transcriptional ...
Jerome Korzelius, Inge The, Suzan Ruijtenberg, Martine B W Prinsen, Vincent Portegijs, Teije C Middelkoop, Marian J Groot Koerkamp, Frank C P Holstege, Mike Boxem, Sander van den Heuvel   +9 more
doaj   +1 more source

Chronic Kidney Disease (CKD) Diagnosis using Machine Learning Methodology Classifications

Iraqi Journal for Computers and Informatics
Early diagnosis of kidney as well as pre-kidney disease is crucial for patients because it allows them to take control of their condition and could potentially avoid or delay more significant consequences that could lower their quality of life.
Ahmed Sami Jaddoa
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Ubiquitin ligase activity inhibits Cdk5 to control axon termination.

PLoS Genetics, 2022
The Cdk5 kinase plays prominent roles in nervous system development, plasticity, behavior and disease. It also has important, non-neuronal functions in cancer, the immune system and insulin secretion.
Muriel Desbois, Karla J Opperman, Jonathan Amezquita, Gabriel Gaglio, Oliver Crawley, Brock Grill   +5 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source