Results 21 to 30 of about 57,522 (220)

Structural insights into the functional diversity of the CDK–cyclin family [PDF]

Open Biology, 2018
Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism
Daniel J. Wood, Jane A. Endicott
doaj   +1 more source

Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

iScience, 2023
Summary: Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints ...
Valdemaras Petrosius, Jan Benada, Olaf Nielsen, Erwin M. Schoof, Claus Storgaard Sørensen   +4 more
doaj   +1 more source

Selective cyclin-dependent kinase 4/6 inhibitors as anticancer drugs: Moving beyond hormone receptor-positive breast cancer

Indian Journal of Medical and Paediatric Oncology, 2019
The cyclin D-cyclin-dependent kinase (CDK) 4/6 pathway controls the cell cycle machinery by regulating the G1-to-S-phase transition. Dysregulation of this pathway, resulting in increased cellular proliferation, is frequently observed in a variety of ...
Tamojit Chaudhuri, K Govind Babu, K C Lakshmaiah, Lokanatha Dasappa, Linu Abraham Jacob, M C Suresh Babu, A H Rudresha, K N Lokesh, L K Rajeev   +8 more
doaj   +1 more source

The origin of CDK regulation [PDF]

Nature Cell Biology, 2001
The initiation of DNA replication is restrained by Cip/Kip proteins that inhibit Cdk2. Degradation of Xenopus Xic1, a Kip1 orthologue, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and (subsequent initiation of replication) is co-ordinately regulated at, and localised to, replication origins.
Li, Anatoliy, Blow, J. Julian
openaire   +3 more sources

Genetic background and climatic droplet keratopathy incidence in a Mapuche population from Argentina. [PDF]

PLoS ONE, 2013
PURPOSE:To determine whether the incidence of and susceptibility to climatic droplet keratopathy (CDK), an acquired, often bilateral degenerative corneal disease, is influenced by the genetic background of the individuals who exhibit the disorder ...
Theodore G Schurr, Matthew C Dulik, Thamara A Cafaro, María F Suarez, Julio A Urrets-Zavalia, Horacio M Serra   +5 more
doaj   +1 more source

Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch

Frontiers in Physiology, 2012
The G1/S transition is a crucial decision point in the cell cycle. At G1/S, there is an abrupt switch from a state of high CDK inhibitor (CKI) levels and low S-phase CDK activity to a state of high S-phase CDK activity and degraded CKI. In budding yeast,
Rainis eVenta, Ervin eValk, Mardo eKõivomägi, Mart eLoog   +3 more
doaj   +1 more source

Capturing CDKs in action: Live-cell biosensors pioneer the new frontiers in cell cycle research

Cell Structure and Function
Cyclin-dependent kinases (CDKs) orchestrate cell cycle progression through precise temporal control of substrate phosphorylation. While traditional biochemical approaches and phosphoproteomics have provided valuable insights into CDK-mediated regulation,
Sachiya Nakashima, Aika Toyama, Hironori Sugiyama, Kazuhiro Aoki, Yuhei Goto   +4 more
doaj   +1 more source

Regulation of a Cyclin-CDK-CDK Inhibitor Complex by Inositol Pyrophosphates [PDF]

Science, 2007
In budding yeast, phosphate starvation triggers inhibition of the Pho80-Pho85 cyclin–cyclin-dependent kinase (CDK) complex by the CDK inhibitor Pho81, leading to expression of genes involved in nutrient homeostasis. We isolated myo - d -inositol ...
Young-Sam, Lee, Sashidhar, Mulugu, John D, York, Erin K, O'Shea   +3 more
openaire   +2 more sources

Chronic Kidney Disease (CKD) Diagnosis using Machine Learning Methodology Classifications

Iraqi Journal for Computers and Informatics
Early diagnosis of kidney as well as pre-kidney disease is crucial for patients because it allows them to take control of their condition and could potentially avoid or delay more significant consequences that could lower their quality of life.
Ahmed Sami Jaddoa
doaj   +1 more source

Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells. [PDF]

PLoS Genetics, 2011
Cell proliferation and differentiation are regulated in a highly coordinated and inverse manner during development and tissue homeostasis. Terminal differentiation usually coincides with cell cycle exit and is thought to engage stable transcriptional ...
Jerome Korzelius, Inge The, Suzan Ruijtenberg, Martine B W Prinsen, Vincent Portegijs, Teije C Middelkoop, Marian J Groot Koerkamp, Frank C P Holstege, Mike Boxem, Sander van den Heuvel   +9 more
doaj   +1 more source