Results 31 to 40 of about 72,294 (253)

CDK-2 is required for dpl-1 and chd-1-mediated suppression of zyg-1.

, 2022
(A) Percent embryonic lethality among the progeny of wild-type and zyg-1(it25) dpl-1(bs21) strains following smd-1 (control) and cdk-2 RNAi. The progeny of wild-type animals subjected to cdk-2(RNAi) exhibit a small reduction in viability.
Peter A. Kropp (11349410), Lindsey K. Gentry (12342729), Prabhu Sankaralingam (12342735), Mary Bergwell (12342732), Yan Liu (25061), Kevin F. O’Connell (3685108), Eric Spooner (155228), Jyoti Iyer (3685111), Bruce Bowerman (36761), Amy Smith (408306), Sarah Guagliardo (5845718)   +10 more
core   +1 more source

CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]

, 2013
Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
Sarkar, S. (Sourav), Sourav Sarkar, Novák, Béla, Tibbles, Katherine L., Prakash Arumugam, Arumugam P., Bela Novak (5648875), Sarkar S., Arumugam Prakash, Arumugam, Prakash, Sourav Sarkar (430861), Katherine Louise Tibbles (478963), Katherine Louise Tibbles, Bela Novak, Sarkar Sourav, Novak Bela, Tibbles Katherine Louise, Prakash Arumugam (303310), Tibbles K.L., Novak B.   +19 more
core   +2 more sources

Cyclin-Dependent Kinase Inhibitors and Their Therapeutic Potential in Colorectal Cancer Treatment

Frontiers in Pharmacology, 2021
Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation. So far, more than ten CDKs have been described. Their direct interaction with cyclins allow progression through G1 phase, transitions to S and G2 phase and finally through mitosis (
Oana-Maria Thoma, Oana-Maria Thoma, Markus F. Neurath, Markus F. Neurath, Maximilian J. Waldner, Maximilian J. Waldner, Maximilian J. Waldner   +6 more
doaj   +1 more source

Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk [PDF]

, 2011
During meiosis, one round of deoxyribonucleic acid replication is followed by two rounds of nuclear division. In Saccharomyces cerevisiae, activation of the Cdc14 early anaphase release (FEAR) network is required for exit from meiosis I but does not lead
Sourav Sarkar, Millar, Jonathan B.A., Kerr, Gary W., Tibbles, Katherine L., Prakash Arumugam, Kerr, Gary, Gary W. Kerr, Sarkar, Sourav, Millar, Jonathan B. A., Katherine L. Tibbles, Jonathan B.A. Millar, Arumugam, Prakash, Mark Petronczki, Petronczki, Mark   +13 more
core   +1 more source

Clinical approach for diagnosing chronic kidney disease based on a series of cases in dogs [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Chronic kidney disease (CDK) is the condition most frequently diagnosed in nephrology in dogs. CDK is progressive and irreversible, but the patient can be treated to decrease the rate of progression and improve the quality of life.
A.M.F.R. Tovar, M.B. Carvalho, G.S. Silva, A. Bizare   +3 more
doaj   +1 more source

CDK-1 levels gradually increase as oocytes become more proximal and are required for NEB at -1 oocytes.

, 2023
A. N2 gonads were dissected, fixed, and stained for DNA (blue) and MPM-2 (white). An increase in MPM-2 signal is observed at the proximal oocyte positions in comparison to more distal oocytes. Scale bar represents a length of 2 μm. B.
Emilie Chien (16632457), W. Matthew Michael (3211092), Mezmur D. Belew (16632454)   +2 more
core   +1 more source

Whi5 regulation by site specific CDK-phosphorylation in Saccharomyces cerevisiae.

PLoS ONE, 2009
The Whi5 transcriptional repressor is a negative regulator of G1 cell cycle progression in Saccharomyces cerevisiae and is functionally equivalent to the Retinoblastoma (Rb) tumor suppressor protein in mammals. In early G1, Whi5 binds to and inhibits SBF
Michelle V Wagner, Marcus B Smolka, Rob A M de Bruin, Huilin Zhou, Curt Wittenberg, Steven F Dowdy   +5 more
doaj   +1 more source

Biological Role of CDK 11 and 12 in Cell Cycle and its Function in Tumorigenesis

Pakistan Journal of Medicine and Dentistry, 2020
Uninhibited proliferation and abnormal cell cycle regulation are the hallmarks of cancer. The main role of cyclin dependent kinases is to regulate the cell cycle and cell proliferation. These protein kinases are frequently down regulated or up regulated
Danish Mohammad, Rida Tafveez, Zain JawedAbubaker, Shamim Mushtaq   +3 more
doaj   +1 more source

Visualizing the metazoan proliferation-quiescence decision in vivo

eLife, 2020
Cell proliferation and quiescence are intimately coordinated during metazoan development. Here, we adapt a cyclin-dependent kinase (CDK) sensor to uncouple these key events of the cell cycle in Caenorhabditis elegans and zebrafish through live-cell ...
Rebecca C Adikes, Abraham Q Kohrman, Michael A Q Martinez, Nicholas J Palmisano, Jayson J Smith, Taylor N Medwig-Kinney, Mingwei Min, Maria D Sallee, Ononnah B Ahmed, Nuri Kim, Simeiyun Liu, Robert D Morabito, Nicholas Weeks, Qinyun Zhao, Wan Zhang, Jessica L Feldman, Michalis Barkoulas, Ariel M Pani, Sabrina L Spencer, Benjamin L Martin, David Q Matus   +20 more
doaj   +1 more source

Selective cyclin-dependent kinase 4/6 inhibitors as anticancer drugs: Moving beyond hormone receptor-positive breast cancer

Indian Journal of Medical and Paediatric Oncology, 2019
The cyclin D-cyclin-dependent kinase (CDK) 4/6 pathway controls the cell cycle machinery by regulating the G1-to-S-phase transition. Dysregulation of this pathway, resulting in increased cellular proliferation, is frequently observed in a variety of ...
Tamojit Chaudhuri, K Govind Babu, K C Lakshmaiah, Lokanatha Dasappa, Linu Abraham Jacob, M C Suresh Babu, A H Rudresha, K N Lokesh, L K Rajeev   +8 more
doaj   +1 more source