CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis. [PDF]
PLoS ONE, 2016 Cell proliferation is driven by cyclical activation of cyclin-dependent kinases (CDKs), which produce distinct biochemical cell cycle phases. Mitosis (M phase) is orchestrated by CDK-1, complexed with mitotic cyclins.
A Sophia Gayek, Ryoma Ohi
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CDK control pathways integrate cell size and ploidy information to control cell division [PDF]
eLife, 2021 Maintenance of cell size homeostasis is a property that is conserved throughout eukaryotes. Cell size homeostasis is brought about by the co-ordination of cell division with cell growth and requires restriction of smaller cells from undergoing mitosis ...
James Oliver Patterson +3 more
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An RB insensitive to CDK regulation
Molecular & Cellular Oncology, 2017 The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays ...
Manel Joaquin +2 more
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Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer [PDF]
MedCommCyclins and cyclin‐dependent kinases (CDKs) are frequently dysregulated in human cancers and represent compelling therapeutic targets. Beyond their well‐recognized roles in cell cycle control, CDK/cyclin complexes orchestrate diverse oncogenic processes,
Suya Zheng +9 more
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Cyclin-dependent kinase-inhibitor screening and structural analysis identify a CDK-like kinase candidate in Naegleria fowleri [PDF]
Parasites & VectorsBackground Primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri is a highly fatal central nervous system infection for which effective treatment options remain limited. This study explored CDK-related pathways in N.
Min-Jeong Kim, Joo Hwan No
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Idiopathic Congenital Dislocation of the Knee: Case Series of Spontaneous Reduction [PDF]
Journal of Orthopaedic Case ReportsIntroduction: Idiopathic congenital dislocation of the knee (CDK) represents a distinct clinical category. Grade III CDK, defined as knee flexion
Nabil Alassaf
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Dynamic regulation of origin firing factors links CDK activity to dormant origin activation [PDF]
Nature CommunicationsEukaryotic cells license far more potential replication origins than they use, but how origin firing rate is tuned in S phase, especially under replication stress, remains unclear. Here, we identify a regulatory mechanism by which cyclin-dependent kinase
Md Shahadat Hossain +5 more
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Customer Appointment Analysis in Automobile Dealerships
Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2022 Appointment scheduling prior to in-person visit to vehicle service centers is a well-known activity in our daily lives; we often do that to save our- selves time during our visits.
Priya Saha +2 more
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A Journey through Time on the Discovery of Cell Cycle Regulation
Cells, 2022 All living organisms on Earth are made up of cells, which are the functional unit of life. Eukaryotic organisms can consist of a single cell (unicellular) or a group of either identical or different cells (multicellular).
Rustem Uzbekov, Claude Prigent
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CDK1/2/5 blockade: killing two birds with one stone
OncoImmunology, 2021 Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death.
Jiao Liu, Rui Kang, Daolin Tang
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