Results 11 to 20 of about 57,313 (205)
BMC Genomics, 2021 Background Cyclin-dependent kinases (CDKs) are protein kinases regulating important cellular processes such as cell cycle and transcription. Many CDK genes also play a critical role during adipogenic differentiation, but the role of CDK gene family in ...
Cuili Pan +8 more
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Cyclin-Dependent Kinase Inhibitors and Their Therapeutic Potential in Colorectal Cancer Treatment
Frontiers in Pharmacology, 2021 Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation. So far, more than ten CDKs have been described. Their direct interaction with cyclins allow progression through G1 phase, transitions to S and G2 phase and finally through mitosis (
Oana-Maria Thoma +6 more
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Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
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An RB insensitive to CDK regulation
Molecular & Cellular Oncology, 2017 The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays ...
Manel Joaquin +2 more
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Clinical approach for diagnosing chronic kidney disease based on a series of cases in dogs [PDF]
Arquivo Brasileiro de Medicina Veterinária e ZootecniaChronic kidney disease (CDK) is the condition most frequently diagnosed in nephrology in dogs. CDK is progressive and irreversible, but the patient can be treated to decrease the rate of progression and improve the quality of life.
A.M.F.R. Tovar +3 more
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Whi5 regulation by site specific CDK-phosphorylation in Saccharomyces cerevisiae.
PLoS ONE, 2009 The Whi5 transcriptional repressor is a negative regulator of G1 cell cycle progression in Saccharomyces cerevisiae and is functionally equivalent to the Retinoblastoma (Rb) tumor suppressor protein in mammals. In early G1, Whi5 binds to and inhibits SBF
Michelle V Wagner +5 more
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Biological Role of CDK 11 and 12 in Cell Cycle and its Function in Tumorigenesis
Pakistan Journal of Medicine and Dentistry, 2020 Uninhibited proliferation and abnormal cell cycle regulation are the hallmarks of cancer. The main role of cyclin dependent kinases is to regulate the cell cycle and cell proliferation. These protein kinases are frequently down regulated or up regulated
Danish Mohammad +3 more
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CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis. [PDF]
PLoS ONE, 2016 Cell proliferation is driven by cyclical activation of cyclin-dependent kinases (CDKs), which produce distinct biochemical cell cycle phases. Mitosis (M phase) is orchestrated by CDK-1, complexed with mitotic cyclins.
A Sophia Gayek, Ryoma Ohi
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Visualizing the metazoan proliferation-quiescence decision in vivo
eLife, 2020 Cell proliferation and quiescence are intimately coordinated during metazoan development. Here, we adapt a cyclin-dependent kinase (CDK) sensor to uncouple these key events of the cell cycle in Caenorhabditis elegans and zebrafish through live-cell ...
Rebecca C Adikes +20 more
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Indian Journal of Medical and Paediatric Oncology, 2019 The cyclin D-cyclin-dependent kinase (CDK) 4/6 pathway controls the cell cycle machinery by regulating the G1-to-S-phase transition. Dysregulation of this pathway, resulting in increased cellular proliferation, is frequently observed in a variety of ...
Tamojit Chaudhuri +8 more
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