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Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1. [PDF]
Cell Death DisKrings KS +15 more
europepmc +1 more source
Molecular Simulation, 2022 CDK-1 and CDK-2 are two promising targets for cancer treatment as they are vital in tumor development, proliferation, and apoptosis during the cell cycle process.
Rajshekhar Karpoormath +2 more
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New Insights into CDK Regulators: Novel Opportunities for Cancer Therapy
Trends in Cell Biology, 2021 Cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), control the transition between different phases of the cell cycle. CDK/cyclin activity is regulated by CDK inhibitors (CKIs), currently comprising the CDK-interacting protein ...
Frédéric Lessard +2 more
exaly +2 more sources
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An Overview of CDK Enzyme Inhibitors in Cancer Therapy
Current Cancer Drug Targets, 2023BM Gurupadayya
exaly
Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes
Cell, 2023Miquel Rosas-Salvans +2 more
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Highlights of the Latest Advances in Research on CDK Inhibitors
Cancers, 2014Deividas Valiunas +2 more
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Recovery from a DNA‐damage‐induced G2 arrest requires Cdk‐dependent activation of FoxM1
EMBO Reports, 2010Lenno Krenning +2 more
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Recent development of CDK inhibitors: An overview of CDK/inhibitor co-crystal structures
European Journal of Medicinal Chemistry, 2019Quancheng Kan, Qingwang Liu, Xin Tian
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