Results 221 to 230 of about 72,294 (253)

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

Aging Cell, Volume 25, Issue 10, October 2026.
Our studies for the first time underscore the feasibility of long‐term SIRT6 activation as a pharmacological strategy to maintain the health of the intervertebral disc in the aging spine. ABSTRACT Aging is a critical risk factor for intervertebral disc degeneration, a major contributor to chronic low back pain.
Pranay Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah E. Bell, Mallory Toci, Olivia Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins, Ruteja A. Barve, Makarand V. Risbud   +11 more
wiley   +1 more source

Food-Derived Natural Compounds as Molecular Targets in Cancer Prevention. [PDF]

Pharmaceutics
Udayasankaran M, Shankar B, Radhakrishnan C, Moorthy SR, Samivel R, Vinayagam R, Gnanasampanthapandian D, Palaniyandi K.   +7 more
europepmc   +1 more source

The Human Ovary Exhibits Dynamic Molecular Remodeling in the Decades Post‐Menopause

Aging Cell, Volume 25, Issue 10, October 2026.
We analyzed the proteomes of healthy ovaries from 28 postmenopausal women (50–75 years old). We quantified 5812 proteins and observed progressive age‐associated shifts. This fundamentally shifts the notion of the postmenopausal ovary as an inert organ and demonstrates continuous molecular remodeling with relevance to tissue signaling and implications ...
Mark A. Watson, Bikem Soygur, Christina D. King, Pooja R. Devrukhkar, Simon Melov, Elisheva D. Shanes, Mary Ellen G. Pavone, Francesca E. Duncan, Birgit Schilling   +8 more
wiley   +1 more source

In-depth examination of the zinc-mitigation of the molecular effects of heat stress-induced intestinal damage in broilers. [PDF]

Poult Sci
Hu Y, Hu Y, Lin X, Liu HC, Odle J, See MT, Zhang L, Luo X.   +7 more
europepmc   +1 more source

The Role of EVs in the Aging Hematopoietic System

Aging Cell, Volume 25, Issue 10, October 2026.
Extracellular vesicles from aged bone marrow carry pro‐inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles therefore represent both a readout of hematopoietic aging and a potential therapeutic route.
Esra G. Kosebent, Nathalie Havranek, Karoline Kollmann, Kristina Kirschner, Eszter Doma, Kavya Gupta   +5 more
wiley   +1 more source

Investigating the Effects of Paralinguistic Configuration in Background Human Speech on Attention: Protocol for a Within-Subject Study. [PDF]

JMIR Res Protoc
Liang Z, Karlsson CD.
europepmc   +1 more source

Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs

Aging Cell, Volume 25, Issue 10, October 2026.
Single‐cell transcriptomic profiling across multiple organs identifies aging reshapes neutrophil differentiation from the bone marrow to peripheral tissues. Computation analysis identifies an age‐enriched Neu06‐IL6 neutrophil state and predicts IL‐6 as one of a candidate regulator for neutrophil remodeling.
Yuman Wang, Teding Chang, Yangguang Fu, Guangyu Liang, Huicheng Liu, Le Zhang, Jinhua Yan, Man Liu, Anding Liu, Cuntai Zhang   +9 more
wiley   +1 more source

Endothelial TLR4 at the Crossroads of Vascular Senescence and Targeted Senotherapeutics

Aging Cell, Volume 25, Issue 10, October 2026.
While Toll‐like receptor 4 (TLR4) mediates essential innate immune responses, its stress‐induced hyperactivation drives vascular endothelial senescence. The subsequent release of the senescence‐associated secretory phenotype (SASP) accelerates tissue aging and exacerbates various age‐related diseases.
Hyo‐Jin Kim, Jeong‐Hyung Lee, Cheol Hwangbo   +2 more
wiley   +1 more source

Chronic Senolytic Treatment and/or Aerobic Exercise Reduce Senescence and Improve Myocardial Function During Aging in the Heart

Aging Cell, Volume 25, Issue 10, October 2026.
Middle aged mice (12‐months‐old) administered senolytics and/or aerobic exercise for 9 months showed a significantly lower accumulation of senescent cardiomyocytes and improved myocardial function compared to mice aged naturally, independent of changes to the SASP.
Ryan T. Bevington, Amanda L. Johnson, Briana L. Hockey, Val A. Fajardo, Gianni Parise   +4 more
wiley   +1 more source