Results 231 to 240 of about 72,294 (253)

Emodin-induced cell cycle arrest: A promising approach for cancer therapy (Review). [PDF]

Med Int (Lond)
Das S, Kompala J, Laney K, Pathak S, Nayar R, Khurana S, Ghezzi A, Karthik L, Banerjee AG.   +8 more
europepmc   +1 more source

The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor‐αKlotho Complex Increases Sinoatrial Electrical Activity

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body phosphorus and calcium homeostasis by activating the FGF1 receptors (FGFR1)/α‐Klotho complex in the kidney and parathyroid glands.
Giorgia Bertoli, Patrizia Benzoni, Serena Canzolino, David Molla, Raffaella Milanesi, Chiara Piantoni, Makoto Kuro‐o, Carmen Delgado, Gema Ruiz‐Hurtado, Mirko Baruscotti, Annalisa Bucchi   +10 more
wiley   +1 more source

Cell cycle dysregulation: a central hub in colitis-associated colorectal carcinogenesis. [PDF]

Front Immunol
Fu Y, Wang Y, Wu S, Ying Y, Li J, Ou Y, Wang Y, Li L, Wu Y, Yan J, Yang Z.   +10 more
europepmc   +1 more source

An Acidic Tubulointerstitial Microenvironment Delays Cell‐Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz, Virginie Dubourg, Lea Schaude, Natalie Schröder, Eva Janßen, Isabelle Görlich, Stefanie Ruhs, Michael Kopf, Michael Gekle   +8 more
wiley   +1 more source

Cyclin-dependent kinase 4/6 inhibitors in granulosa cell tumors and their combination with hormonal therapy: a scoping review. [PDF]

Front Oncol
Pacholczak-Madej R, Łupkowski R, Górniak K, Puskulluoglu M.   +3 more
europepmc   +1 more source

A Type II CDK6 Degrader Enables Cellular Targeting beyond the Limits of Type II Inhibition. [PDF]

J Am Chem Soc
Kim JH, Mills CE, Kozicka Z, Scott DC, Jin C, Jiang Z, Dwyer BG, Geng Q, Toenjes ST, Byun WS, ElHarouni D, Li H, Ligon KL, Thornhill AM, Jones HM, Romero BA, Hinshaw SM, Ebert BL, Schulman BA, Donovan KA, Fischer ES, Gray NS.   +21 more
europepmc   +1 more source

Combined CDK4/6 Inhibition and Radiation: Effects on Cellular Senescence, Cell Cycle Regulation, and Cell Death in Mammary Carcinoma Cells. [PDF]

Cells
Quarz L, Distel LV, Corradini S, Hildebrand LS.   +3 more
europepmc   +1 more source

Contact-Network Phenotyping of the CDK Family Reveals Selective Distal C-Lobe Contact Redistribution by Modern CDK5 Inhibitors and a Quantitative Selectivity Landscape against CDK2 and CDK1. [PDF]

J Chem Inf Model
Nael MA, Alakonda LM, Elokely KM.
europepmc   +1 more source

Oral Estrogen Receptor Degraders Compared to Standard Endocrine Therapy in Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: A Systematic Review and Meta-Analysis. [PDF]

Cancers (Basel)
Goldvaser H, Khutsurauli S, Buchinger M, Safonov A, Grinshpun A.   +4 more
europepmc   +1 more source