SSUP-72/PINN-1 coordinates RNA-polymerase II 3' pausing and developmental gene expression in C. elegans. [PDF]
Nat CommunStubbe FX +3 more
europepmc +1 more source
Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins [PDF]
, 2002 Isabelle Frouin +5 more
openalex +1 more source
CDK inhibitors: cell cycle regulators and beyond.
Developmental Cell, 2008 A. Besson, S. Dowdy, James M. Roberts
semanticscholar +1 more source
Engineering the Future of Restorative Clinical Peripheral Nerve Surgery
Advanced Healthcare Materials, Volume 14, Issue 20, August 8, 2025.What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell +5 more
wiley +1 more source
Loss of G1-phase CDK-inhibition biases instability between genomic regions by unevenly reducing activity among replication origins. [PDF]
iScienceGomes F +9 more
europepmc +1 more source
Advanced Science, Volume 12, Issue 29, August 7, 2025.Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao +13 more
wiley +1 more source
LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5
Advanced Science, Volume 12, Issue 29, August 7, 2025.Li et al. innovatively map the kinase‐substrate network in esophageal cancer metastasis. Their study demonstrates that LIM domain kinase 1 (LIMK1) and Cyclin‐dependent kinase 5 (CDK5) synergistically increase the phosphorylation of β‐catenin, thereby activating the Wnt/β‐catenin signaling pathway to promote esophageal cancer metastasis.
Shu‐Jun Li +27 more
wiley +1 more source
Dynamic SAS-6 phosphorylation aids centrosome duplication and elimination in C. elegans oogenesis. [PDF]
EMBO RepQi F +15 more
europepmc +1 more source
Borrelidin Inhibits a Cyclin-dependent Kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae.
, 2001 Eiko Tsuchiya +4 more
openalex +2 more sources
Cancer Medicine, Volume 14, Issue 15, August 2025.Comparative analysis of thiotepa plus vinorelbine versus vinorelbine alone in patients with HER2‐negative metastatic breast cancer, using a propensity score emulated target trial. While no progression‐free survival benefit was observed in the overall population, vinorelbine–thiotepa was associated with significantly improved median progression‐free ...
Aurelia Robert +15 more
wiley +1 more source