Results 311 to 320 of about 74,242 (343)
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Cohesin and Cdk1: an anaphase barricade
Nature Cell Biology, 2010Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
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CDK1 in Breast Cancer: Implications for Theranostic Potential.
Anti-Cancer Agents in Medicinal Chemistry, 2020Breast cancer has been identified as one of the main cancer-related deaths among women during some last decades. Recent advances in the introduction of novel potent anti-cancer therapeutics in association with early detection methods led to a decrease in
Sepideh Izadi +7 more
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Cdk1 and cell morphology: connections and directions
Current Opinion in Cell Biology, 2009Cells undergo dramatic shape transitions as they progress through the cell cycle. Here, we discuss how communication between the ubiquitous cell cycle regulator Cdk1 and cell morphology factors such as Cdc42 coordinates the cell cycle and cell morphology in the budding and fission yeasts.
James B, Moseley, Paul, Nurse
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CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer
Gut, 2020Objective Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy.
Jin Huang +13 more
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2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors
Bioorganic & Medicinal Chemistry Letters, 2003Purine inhibitors of cyclin-dependent kinases attract attention as potential anticancer drugs because their first representative roscovitine recently entered clinical trials. Although well described in terms of structure-activity relationships, we still present here a novel modification of the purine scaffold influencing their inhibitory properties ...
Jirí, Moravec +9 more
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2014
Cdk1 is an important cell cycle regulator that, in association with different cyclin regulatory subunits, is responsible for signaling important cell cycle events in all eukaryotic cells. In budding yeast, inhibition of Cdk1 by selective deletion of cyclin subunits has been shown to prevent anaphase onset, suggesting that Cdk1 activity is critically ...
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Cdk1 is an important cell cycle regulator that, in association with different cyclin regulatory subunits, is responsible for signaling important cell cycle events in all eukaryotic cells. In budding yeast, inhibition of Cdk1 by selective deletion of cyclin subunits has been shown to prevent anaphase onset, suggesting that Cdk1 activity is critically ...
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High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma.
Gene, 2019BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer-related death. Increasing evidence suggests that cell cycle dysregulation is one of the hallmarks of cancer.
J. Piao +6 more
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Cep63 Recruits Cdk1 to the Centrosome—Letter
Cancer Research, 2015In 2011, we published a characterization of the phenotypes of Cep63 downregulation and overexpression in human cells in Cancer Research ([1][1]). Recently, it was shown that several antibodies commonly used to detect Cdk1 cross-react with Cep152 ([2][2]).
Mohammad, Alsara +4 more
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Characterization of a novel cdk1‐related kinase
European Journal of Biochemistry, 1999The p13suc1/p9CKShs proteins bind tightly to the cyclin‐dependent kinases cdk1 and cdk2. The distantly related protein, p15cdk‐BP, binds cdk4/6, cdk5 and cdk8. We now show that immobilized p15cdk‐BP binds both an HMG‐I kinase and a 35‐kDa protein that cross‐reacts with anti‐PSTAIRE antibodies (PSTAIRE is a totally conserved motif located in subdomain ...
L, Détivaud, G R, Pettit, L, Meijer
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Cdk1: the dominant sibling of Cdk2
Nature Cell Biology, 2005Cdk2 is thought to regulate entry into S phase, whereas Cdk1 controls the initiation of mitosis. New evidence shows that Cdk1 is equally capable of promoting the G1/S transition in Cdk2−/− cells, raising the question as to whether Cdk1 constitutes the predominant cyclin-dependent kinase in mammalian cells, or only compensates for Cdk2 function when it ...
Tarig Bashir, Michele Pagano
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