Results 121 to 130 of about 28,778 (201)
Neurobiology of Disease, 2001 The potential contribution of cyclin-dependent protein kinase 5 (cdk5) to hyperphosphorylate protein tau, as claimed in Alzheimer's disease, was investigated in vivo.
C. Van den Haute +7 more
doaj +1 more source
The novel E3 ligase of PPAR?? TRIM25 regulates adipocyte differentiation [PDF]
, 2018 Department of Biological SciencesPeroxisome proliferator-activated receptor ?? (PPAR??) is a ligand-dependent transcription factor which regulates glucose homeostasis and adipocyte differentiation.
Lee, Jae Min
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CDK5: A new lead to survival [PDF]
Cell Cycle, 2013 The protein kinase CDK5 was originally discovered at a time when cyclin-dependent kinases were thought to be involved exclusively in cell cycle control. The CDK5 catalytic subunit was first identified based on its nucleotide sequence homology to other known CDK family members (cdc2, CDK2),1 while the enzyme activity was identified by protein ...
openaire +2 more sources
Neoplasia: An International Journal for Oncology ResearchAberrant expression of cyclin-dependent kinase 5 (Cdk5) has been reported in pituitary adenomas. However, the role of Cdk5 in the tumorigenesis remains unclear. We show that prenatal p25-activated Cdk5 phosphorylates minichromosome maintenance protein 2 (
Yingwei Huang +23 more
doaj +1 more source
CDK5 promotes HCC genesis and promotes cell migration by TPX2 [PDF]
, 2016 我国是世界上肝癌最高发的国家之一，由于其较高的发病率和致死率，严重威胁人民的健康，但目前大多数肝癌患者仍难以获得早期诊断及有效的治疗。细胞周期蛋白依赖性激酶5(cyclin-dependentkinase5，CDK5)是周期素依赖蛋白激酶家族的特殊成员，近年来发现其在肿瘤发生发展中起着关键的作用。CDK5通过与激活因子p35或p39结合后活化并磷酸化一系列下游分子，参与肿瘤细胞增殖、迁移、粘附、凋亡、细胞周期调控等。但CDK5对肝癌细胞功能的影响及其在肝癌中的调控机制还不清楚 ...
王付强
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Tumour Virus ResearchThe E6 oncoprotein encoded by the cancer-causing human papillomavirus (HPV) is vital for maintaining the ability of the virus to promote cell proliferation and cancer progression.
Chuanyun Xiao +4 more
doaj +1 more source
The CDK inhibitors in cancer research and therapy [PDF]
, 2018 Chemical compounds that interfere with an enzymatic function of kinases are useful for gaining insight into the complicated biochemical processes in mammalian cells.
Cicenas, Jonas, Valius, Mindaugas
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Influence of epigallocatechin-3-gallate on okadaic acid-induced cell death [PDF]
, 2015 Okadaična kiselina je selektivni inhibitor serin/treonin fosfataza (PP1 i PP2A) koje kataliziraju defosforilaciju tau proteina i pojačava ekspresiju gena cdk5 i p25. Cdk5 inhibira fosfataze i time inducira hiperfosforilaciju tau proteina.
Kopčok, Vedrana
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