Results 171 to 180 of about 17,484 (210)

Activity-dependent phosphorylation of CDYL by CDK5 regulates fear memory in mice. [PDF]

Transl Psychiatry
Lyu NY, Xie GG, Hu ZW, Lyu TJ, Qin R, Chen L, Wang Y.   +6 more
europepmc   +1 more source

Mechanically sensitized hydrogel microspheres trigger membrane receptor switch for cartilage repair. [PDF]

Bioact Mater
Lin F, Yao L, Xu Y, Xiang L, Zhang N, Zhuang Y, Jiang Q, Zhang Z, Cao Q, Chen J, Jiang L, Qian S, Shi Y, Xue D, Bao L, Yu X, Ye Z, Cui W.   +17 more
europepmc   +1 more source

miR-432 Exacerbates Obesity-Induced Dysregulation of Glucose and Lipid Homeostasis. [PDF]

Diabetes
Wang C, Hou Y, Zhang M, Wang J, Chu X, Liang M, Sun C, Xie J, Zhang J, Wang CY.   +9 more
europepmc   +1 more source

Discovery of small molecules and a druggable groove that regulate DNA binding and release of the AP-1 transcription factor ΔFOSB. [PDF]

J Biol Chem
McNeme S, Yim YY, Kumar A, Li Y, Hughes B, St Romain CP, Aglyamova G, Chen J, Nguyen ND, Fan S, Stephens GS, Zhao WN, Kruzshak S, Estill M, Brener C, Tofani S, Kumar A, Chen EP, Takatka N, Robison AJ, Chen H, Powell RT, Haggarty SJ, Stephan C, Nestler EJ, Chin J, Machius M, Zhou J, Rudenko G.   +28 more
europepmc   +1 more source

The Role of Serotonin in Brain Development: From Molecular Pathways to Neurodevelopmental Risk. [PDF]

Cell Mol Neurobiol
Chan WK, Rasmusson S, Shiadeh SMJ, Wilhelmsson R, Johansson ME, Elfving B, Müller HK, Mallard C, Ardalan M.   +8 more
europepmc   +1 more source

Tauopathies: Calmodulin Regulates Tau Hyperphosphorylation and Its Transformation into Disease-Specific Aggregates. [PDF]

Biomolecules
O'Day DH.
europepmc   +1 more source

Disruption of CDK5 regulatory subunit 1, p35, limits immunosuppressive M2 macrophages while maintaining functional M1 macrophages. [PDF]

Front Immunol
Zampieri JR, Choi SH, Myers JT, Tomchuck SL, Eid S, Askew D, Huang AY.   +6 more
europepmc   +1 more source

Monoclonal antibodies and small molecules: on the cutting edge of Alzheimer's disease therapy. [PDF]

Front Cell Dev Biol
Ouro A, Ben-Dor GA, Debasa-Mouce M, Gulkarov S, De Leon J, Castro-Mosquera M, Sobrino T, Bougea A, Reiss AB.   +8 more
europepmc   +1 more source

A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

Proceedings of the National Academy of Sciences of the United States of America, 2023
Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of the Cdk5 activator p35 into the truncated product p25, leading to prolonged Cdk5 activation and altered substrate specificity. Elevated p25 levels have been reported in humans and
Jay Penney, Debasis Patnaik, Ute Geigenmüller   +2 more
exaly   +6 more sources

Some of the next articles are maybe not open access.

Related searches:

A decade of CDK5

Nature Reviews Molecular Cell Biology, 2001
Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug ...
Li-Huei Tsai, Tsai Li-Huei
exaly   +3 more sources