Results 181 to 190 of about 17,484 (210)
The Emerging Role of Cdk5 in Cancer [PDF]
Trends in Cancer, 2016 Cdk5 is an atypical cyclin-dependent kinase that is well characterized for its role in the central nervous system rather than in the cell cycle. However Cdk5 has been recently implicated in the development and progression of a variety of cancers including breast, lung, colon, pancreatic, melanoma, thyroid and brain tumors.
Karine Pozo, James A Bibb
exaly +3 more sources
Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5 [PDF]
Journal of Biological Chemistry, 2014 Cdk5 is a member of the cyclin-dependent kinase (Cdk) family. In contrast to other Cdks that promote cell proliferation, Cdk5 plays a role in regulating various neuronal functions, including neuronal migration, synaptic activity, and neuron death. Cdks responsible for cell proliferation need phosphorylation in the activation loop for activation in ...
Taro Saito, Ko Sato, Koji Tsutsumi
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Trends in Neurosciences, 2002
Recent research points to an involvement of deregulated cdk5 activity in the pathogenesis of mutant SOD1-mediated disease. In addition, inhibition of this activity might promote motor neuron survival. These observations have opened the door to further research into the role of cdk5 in ALS and other neurodegenerative diseases.
Li-Huei Tsai
exaly +3 more sources
Recent research points to an involvement of deregulated cdk5 activity in the pathogenesis of mutant SOD1-mediated disease. In addition, inhibition of this activity might promote motor neuron survival. These observations have opened the door to further research into the role of cdk5 in ALS and other neurodegenerative diseases.
Li-Huei Tsai
exaly +3 more sources
MAP1B phosphorylation is differentially regulated by Cdk5/p35, Cdk5/p25, and JNK
Biochemical and Biophysical Research Communications, 2005Mode I phosphorylated MAP1B is observed in developing and pathogenic brains. Although Cdk5 has been believed to phosphorylate MAP1B in the developing cerebral cortex, we show that a Cdk5 inhibitor does not suppress mode I phosphorylation of MAP1B in primary and slice cultures, while a JNK inhibitor does.
Takeshi Kawauchi +2 more
exaly +3 more sources
Cdk5-p39 is a labile complex with the similar substrate specificity to Cdk5-p35
Journal of Neurochemistry, 2007AbstractCyclin‐dependent kinase 5 (Cdk5) is a proline‐directed Ser/Thr kinase that plays important roles in various neuronal activities, including neuronal migration, synaptic activity, and neuronal cell death. Cdk5 is activated by association with a neuron‐specific activator, p35 or its isoform p39, but little is known about the kinase activity of ...
Taro Saito +2 more
exaly +3 more sources
Nature Neuroscience, 2001
Acetylcholine receptor gene expression is induced locally at the developing neuromuscular junction. A new paper shows that this process requires cyclin-dependent kinase 5.
Ming-Sum Lee, Li-Huei Tsai
openaire +1 more source
Acetylcholine receptor gene expression is induced locally at the developing neuromuscular junction. A new paper shows that this process requires cyclin-dependent kinase 5.
Ming-Sum Lee, Li-Huei Tsai
openaire +1 more source
Discovery of CDK5 Inhibitors through Structure-Guided Approach
ACS Medicinal Chemistry Letters, 2019 Data source: Supporting information, https://doi.org/10.1021/acsmedchemlett.9b00029 Link to a related website: https://figshare.com/articles/Discovery_of_CDK5_Inhibitors_through_Structure-Guided_Approach/7880807/files/14671538.pdf, Open Access via ...
Solomon Tadesse +2 more
exaly +2 more sources
Cdk5: A main culprit in neurodegeneration
International Journal of Neuroscience, 2019Objectives: Neurodegenerative diseases (NDs) such as Alzheimer Diseases (AD), Parkinson Diseases (PD) are a huge public health problem. The elucidation of their pathophysiological mechanism is one of our greatest challenges. Hyperactive immune system contributes to the pathophysiology of neurological disorders.
Krishna Kant, Gupta +1 more
openaire +2 more sources
Expression of Cdk5, p35, and Cdk5-associated kinase activity in the developing rat lens
Developmental Genetics, 1997We have investigated the expression of Cdk5 and its regulatory subunit, p35, in the developing rat lens from embryonic day 16 (E16) to postnatal day 8 (P8). Reverse transcription and polymerase chain reaction (RT/PCR) detected Cdk5 and p35 mRNA expression in lens epithelial cells and in differentiating lens fibers throughout this developmental period ...
C Y, Gao +4 more
openaire +2 more sources
The Role of Cdk5 in Alzheimer’s Disease
Molecular Neurobiology, 2015Alzheimer's disease (AD) is known as the most fatal chronic neurodegenerative disease in adults along with progressive loss of memory and other cognitive function disorders. Cyclin-dependent kinase 5 (Cdk5), a unique member of the cyclin-dependent kinases (Cdks), is reported to intimately associate with the process of the pathogenesis of AD. Cdk5 is of
Shu-Lei, Liu +5 more
openaire +2 more sources