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Nature Reviews Molecular Cell Biology, 2001
Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug ...
R, Dhavan, L H, Tsai
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Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug ...
R, Dhavan, L H, Tsai
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Trends in Neurosciences, 2002
Recent research points to an involvement of deregulated cdk5 activity in the pathogenesis of mutant SOD1-mediated disease. In addition, inhibition of this activity might promote motor neuron survival. These observations have opened the door to further research into the role of cdk5 in ALS and other neurodegenerative diseases.
Holger, Patzke, Li Huei, Tsai
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Recent research points to an involvement of deregulated cdk5 activity in the pathogenesis of mutant SOD1-mediated disease. In addition, inhibition of this activity might promote motor neuron survival. These observations have opened the door to further research into the role of cdk5 in ALS and other neurodegenerative diseases.
Holger, Patzke, Li Huei, Tsai
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MAP1B phosphorylation is differentially regulated by Cdk5/p35, Cdk5/p25, and JNK
Biochemical and Biophysical Research Communications, 2005Mode I phosphorylated MAP1B is observed in developing and pathogenic brains. Although Cdk5 has been believed to phosphorylate MAP1B in the developing cerebral cortex, we show that a Cdk5 inhibitor does not suppress mode I phosphorylation of MAP1B in primary and slice cultures, while a JNK inhibitor does.
Takeshi, Kawauchi +4 more
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Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5
Biotechnology Journal, 2007AbstractNormal Cdk5 activity, conferred mainly by association with its primary activator p35, is critical for normal function of the cell and must be tightly regulated. During neurotoxicity, p35 is cleaved to form p25, which becomes a potent and mislocalized hyperactivator of Cdk5, resulting in a deregulation of Cdk5 activity.
Sashi, Kesavapany +3 more
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2008
Recent studies have explored the indispensable roles of Cdk5 in presynapse. Presynapse is the structure in which neurotransmitter-containing synaptic vesicles are fused to the synaptic membrane and recycled to internal compartments via exocytosis and endocytosis, respectively.
Fan-Yan Wei, Kazuhito Tomizawa
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Recent studies have explored the indispensable roles of Cdk5 in presynapse. Presynapse is the structure in which neurotransmitter-containing synaptic vesicles are fused to the synaptic membrane and recycled to internal compartments via exocytosis and endocytosis, respectively.
Fan-Yan Wei, Kazuhito Tomizawa
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Expression of Cdk5, p35, and Cdk5-associated kinase activity in the developing rat lens
Developmental Genetics, 1997We have investigated the expression of Cdk5 and its regulatory subunit, p35, in the developing rat lens from embryonic day 16 (E16) to postnatal day 8 (P8). Reverse transcription and polymerase chain reaction (RT/PCR) detected Cdk5 and p35 mRNA expression in lens epithelial cells and in differentiating lens fibers throughout this developmental period ...
C Y, Gao +4 more
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Science of Aging Knowledge Environment, 2006
The cyclin-dependent kinase-5 (Cdk5) is critical to normal mammalian development and has been implicated in synaptic plasticity, learning, and memory in the adult brain. But Cdk-5 activity has also been linked to neurodegenerative diseases. Could a single protein have opposing effects?
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The cyclin-dependent kinase-5 (Cdk5) is critical to normal mammalian development and has been implicated in synaptic plasticity, learning, and memory in the adult brain. But Cdk-5 activity has also been linked to neurodegenerative diseases. Could a single protein have opposing effects?
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2023
The Hippo-YAP/TAZ pathway is the most prevalent evolutionary conserved pathway from Drosophila to mammals and plays a key role in controlling organ size, cell growth, self-renewal, and tissue homeostasis. Hippo pathway consists of MST/LATS kinase module and YAP/TAZ-TEAD transcription module and is generally regulated by transcriptional activity of YAP ...
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The Hippo-YAP/TAZ pathway is the most prevalent evolutionary conserved pathway from Drosophila to mammals and plays a key role in controlling organ size, cell growth, self-renewal, and tissue homeostasis. Hippo pathway consists of MST/LATS kinase module and YAP/TAZ-TEAD transcription module and is generally regulated by transcriptional activity of YAP ...
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Cdk5: A main culprit in neurodegeneration
International Journal of Neuroscience, 2019Objectives: Neurodegenerative diseases (NDs) such as Alzheimer Diseases (AD), Parkinson Diseases (PD) are a huge public health problem. The elucidation of their pathophysiological mechanism is one of our greatest challenges. Hyperactive immune system contributes to the pathophysiology of neurological disorders.
Krishna Kant, Gupta +1 more
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