Results 1 to 10 of about 6,157 (185)

Psychometric properties, pragmatic screening cut‐offs, and feasibility of two Clock Drawing Test formats in older psychiatric outpatients: Associations with MMSE and HDS‐R [PDF]

PCN Reports
Aim To compare the psychometric properties, pragmatic screening cut‐offs, and feasibility of two Clock Drawing Test (CDT) formats in older psychiatric outpatients.
Takayo Hatasaki, Norio Sugawara, Yasushi Kawamata, Chie Hasegawa, Norio Yasui‐Furukori   +4 more
doaj   +3 more sources

CDT1, transcriptionally regulated by E2F2, promotes lung adenocarcinoma progression

Heliyon
CDT1, a gene that shows excessive expression in various malignancies, functions as a pivotal regulator of replication licensing. In this study, we observed a positive correlation in expression between CDT1 and E2F2 among patients with lung adenocarcinoma
Wei Liu
exaly   +5 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage [PDF]

FEBS Open Bio
Cdc10‐dependent transcript 1 (CDT1) is an essential protein for DNA replication licensing, which loads the mini‐chromosome maintenance (MCM) complex onto replication origins.
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
doaj   +2 more sources

Integrating single-cell analysis and machine learning algorithms to explore lactylation-related molecular mechanisms and therapeutic responses in clear cell renal cell carcinoma and identifying CDT1 as a potential biomarker [PDF]

Frontiers in Endocrinology
Background and aimLactylation is a novel histone modification driven by lactate accumulation, which has been implicated in clear cell renal cell carcinoma (ccRCC) progression.
Yue Zhang, Hang Zhou, Hang Zhou, Bihui Zhang, Xianchao Sun, Wangli Mei, Wangli Mei, Lin Zhou   +7 more
doaj   +2 more sources

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions [PDF]

Nature Communications
DNA replication is tightly regulated to occur once per cell cycle, with the MCM2-7 helicase loaded onto replication origins only during G1-phase. In higher eukaryotes, geminin negatively regulates this process during S-, G2- and M-phases by binding the ...
Joshua Tomkins, Lucy V. Edwardes, Sarah V. Faull, Matthew Peach, Peter J. Gillespie, Vera Leber, Anna Schmidt, Halil Bounoua, Nicholas Sim, Rosa Camarillo, J. Julian Blow, Alexis R. Barr, Anna Barnard, Christian Speck   +13 more
doaj   +2 more sources

BHLHE22, targeted by deubiquitinating enzyme OTUD3, exerts an antitumor role in triple-negative breast cancer progression via transcriptionally inhibiting CDT1 [PDF]

Breast Cancer Research
Background Basic helix-loop-helix family, member e22 (BHLHE22), a basic helix loop helix transcription factor family member, functions vary in different types of cancer. Currently, its function in triple-negative breast cancer (TNBC) is unclear.
Lei Jiang, Junnan Xu, Cui Jiang, Yufeng Jia, Ye Zhang, Tao Sun   +5 more
doaj   +2 more sources

Chromatin licensing and DNA replication factor 1 as a potential prognostic and diagnostic biomarker for gastric cancer [PDF]

Scientific Reports
Accurate and timely genetic material replication is essential for preserving genomic integrity. The replication process begins with chromatin licensing and DNA replication factor 1 (CDT1). It has been demonstrated that dysregulated CDT1 expression causes
Sijia Wang, Min Cui, Na Zhou, Meichen Tong, Shuhua Wu, Hong Li, Zhang Cao   +6 more
doaj   +2 more sources

Combining AI to reveal CCDC3-mediated pathways of colorectal cancer liver metastasis [PDF]

npj Digital Medicine
In colorectal cancer liver metastases, chromosomal instability (CIN) serves as a critical hallmark linked to tumor aggressiveness and poor prognosis. This study integrated single-cell RNA sequencing, weighted gene co-expression network analysis, and non ...
Runze Huang, Qinyu Liu, Xin Jin, Xuanci Bai, Yibin Wu, Xigan He, Yixiu Wang, Ziting Jiang, Yongfa Zhang, Yi Shi, Lu Wang, Weiping Zhu   +11 more
doaj   +2 more sources

An open-source pipeline for longitudinal single-cell tracking and cell-cycle/migration coupling analysis for neurotherapeutic screening. [PDF]

Neuroprotection
Integrated experimental and computational pipeline for longitudinal single‐cell tracking and cell‐cycle dynamics analysis. Schematic of the FUCCI (Fluorescence Ubiquitination‐based Cell Cycle Indicator) reporter system. The construct is driven by the CAG promoter (CMV enhancer + chicken β‐actin promoter) and encodes two fusion proteins: mKO2‐Cdt1 ...
Chandra N, Yang M, Wang H, Janowski M, Walczak P, Allier C, Liang Y.   +6 more
europepmc   +2 more sources

Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics [PDF]

Nature Communications
Cyclin-dependent kinases (CDKs) coordinate DNA replication and cell division, and play key roles in tissue homeostasis, genome stability and cancer development.
Anastasia Sosenko Piscitello, Ann-Sofie Nilsson, Michael Hawgood, Abid H. Sayyid, Vasilis S. Dionellis, Giovanni Giglio, Bruno Urién, Pratikiran Bajgain, Sotirios G. Ntallis, Jiri Bartek, Thanos D. Halazonetis, Bennie Lemmens   +11 more
doaj   +2 more sources