Results 1 to 10 of about 5,745 (188)

CDT1, transcriptionally regulated by E2F2, promotes lung adenocarcinoma progression [PDF]

Heliyon
CDT1, a gene that shows excessive expression in various malignancies, functions as a pivotal regulator of replication licensing. In this study, we observed a positive correlation in expression between CDT1 and E2F2 among patients with lung adenocarcinoma
Ｗei Liu
exaly   +6 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage [PDF]

FEBS Open Bio
Cdc10‐dependent transcript 1 (CDT1) is an essential protein for DNA replication licensing, which loads the mini‐chromosome maintenance (MCM) complex onto replication origins.
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
doaj   +3 more sources

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions [PDF]

Nature Communications
DNA replication is tightly regulated to occur once per cell cycle, with the MCM2-7 helicase loaded onto replication origins only during G1-phase. In higher eukaryotes, geminin negatively regulates this process during S-, G2- and M-phases by binding the ...
Joshua Tomkins, Lucy V. Edwardes, Sarah V. Faull, Matthew Peach, Peter J. Gillespie, Vera Leber, Anna Schmidt, Halil Bounoua, Nicholas Sim, Rosa Camarillo, J. Julian Blow, Alexis R. Barr, Anna Barnard, Christian Speck   +13 more
doaj   +3 more sources

Psychometric properties, pragmatic screening cut-offs, and feasibility of two Clock Drawing Test formats in older psychiatric outpatients: Associations with MMSE and HDS-R. [PDF]

PCN Rep
Abstract Aim To compare the psychometric properties, pragmatic screening cut‐offs, and feasibility of two Clock Drawing Test (CDT) formats in older psychiatric outpatients. Methods We retrospectively analyzed 447 outpatients aged ≥65 years who completed the Mini‐Mental State Examination (MMSE), the Hasegawa Dementia Scale‐Revised (HDS‐R), and two CDT ...
Hatasaki T, Sugawara N, Kawamata Y, Hasegawa C, Yasui-Furukori N.   +4 more
europepmc   +2 more sources

License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication. [PDF]

Bioessays
Origin licensing constitutes the first step in initiating eukaryotic genome replication. Licensed origins are marked by an MCM double hexamer complex. This article reviews the molecular mechanisms of MCM double hexamer loading in yeast and higher eukaryotes, based on insights gained from biochemical reconstitution and structural analyses.
Frisbie V, Bleichert F.
europepmc   +2 more sources

Transforming RNA Degradation into Accurate RNA Detection: RNase I-Assisted Rolling Circle Amplification for Clinical Samples. [PDF]

Angew Chem Int Ed Engl
Here, we transform this otherwise destructive enzymatic activity into a powerful diagnostic advantage through an RNase I–assisted rolling circle amplification (RI‐RCA) strategy. By integrating controlled RNase I–mediated RNA digestion with circular DNA templates, this approach enables direct and highly sensitive detection of target RNA sequences. Using
Mathai A, Lee CY, Zhang Z, Gu J, Brennan JD, Li Y.   +5 more
europepmc   +3 more sources

Chromatin licensing and DNA replication factor 1 as a potential prognostic and diagnostic biomarker for gastric cancer [PDF]

Scientific Reports
Accurate and timely genetic material replication is essential for preserving genomic integrity. The replication process begins with chromatin licensing and DNA replication factor 1 (CDT1). It has been demonstrated that dysregulated CDT1 expression causes
Sijia Wang, Min Cui, Na Zhou, Meichen Tong, Shuhua Wu, Hong Li, Zhang Cao   +6 more
doaj   +2 more sources

BHLHE22, targeted by deubiquitinating enzyme OTUD3, exerts an antitumor role in triple-negative breast cancer progression via transcriptionally inhibiting CDT1 [PDF]

Breast Cancer Research
Background Basic helix-loop-helix family, member e22 (BHLHE22), a basic helix loop helix transcription factor family member, functions vary in different types of cancer. Currently, its function in triple-negative breast cancer (TNBC) is unclear.
Lei Jiang, Junnan Xu, Cui Jiang, Yufeng Jia, Ye Zhang, Tao Sun   +5 more
doaj   +2 more sources

Combining AI to reveal CCDC3-mediated pathways of colorectal cancer liver metastasis [PDF]

npj Digital Medicine
In colorectal cancer liver metastases, chromosomal instability (CIN) serves as a critical hallmark linked to tumor aggressiveness and poor prognosis. This study integrated single-cell RNA sequencing, weighted gene co-expression network analysis, and non ...
Runze Huang, Qinyu Liu, Xin Jin, Xuanci Bai, Yibin Wu, Xigan He, Yixiu Wang, Ziting Jiang, Yongfa Zhang, Yi Shi, Lu Wang, Weiping Zhu   +11 more
doaj   +2 more sources

Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics [PDF]

Nature Communications
Cyclin-dependent kinases (CDKs) coordinate DNA replication and cell division, and play key roles in tissue homeostasis, genome stability and cancer development.
Anastasia Sosenko Piscitello, Ann-Sofie Nilsson, Michael Hawgood, Abid H. Sayyid, Vasilis S. Dionellis, Giovanni Giglio, Bruno Urién, Pratikiran Bajgain, Sotirios G. Ntallis, Jiri Bartek, Thanos D. Halazonetis, Bennie Lemmens   +11 more
doaj   +2 more sources