Results 11 to 20 of about 5,745 (188)
Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs. [PDF]
PLoS ONE, 2012 BACKGROUND: Maintenance of genome integrity is crucial for the propagation of the genetic information. Cdt1 is a major component of the pre-replicative complex, which controls once per cell cycle DNA replication. Upon DNA damage, Cdt1 is rapidly targeted
Athanasia Stathopoulou +7 more
doaj +5 more sources
USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication [PDF]
Molecular Oncology, 2016 DNA replication control is a key process in maintaining genomic integrity. Monitoring DNA replication initiation is particularly important as it needs to be coordinated with other cellular events and should occur only once per cell cycle. Crucial players
Santiago Hernández-Pérez +7 more
doaj +7 more sources
The prognostic significance of Cdc6 and Cdt1 in breast cancer [PDF]
Scientific Reports, 2017 DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers ...
Ravikiran Mahadevappa +8 more
doaj +7 more sources
Cdt1 stabilizes an open MCM ring for helicase loading [PDF]
Nature Communications, 2017 The loading and activation of the Mcm2-7 replicative helicase couples cell cycle progression to DNA replication. Here the authors use X-ray crystallography and single-particle electron microscopy to demonstrate how Ctd1 functions to promote MCM loading ...
Jordi Frigola +9 more
doaj +8 more sources
Identification of CDT1 as a prognostic marker in human lung adenocarcinoma using bioinformatics approaches [PDF]
PeerJ, 2023 Background Lung cancer has the highest cancer-related mortality worldwide. Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer (NSCLC).
Jing Jiang +12 more
doaj +3 more sources
Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage [PDF]
Journal of Biological Chemistry, 2008 The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA replication initiation. Mechanisms to ensure that metazoan origins initiate once per cell cycle include degradation of Cdt1 during S phase and inhibition of Cdt1 by the geminin protein.
Jonathan R, Hall +6 more
openaire +4 more sources
CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma [PDF]
Frontiers in Oncology, 2021 ObjectiveHepatocellular carcinoma (HCC) is one of the most common malignant tumors endangering human health and life in the 21st century. Chromatin licensing and DNA replication factor 1 (CDT1) is an important regulator of DNA replication licensing ...
Chenhui Cai +6 more
doaj +3 more sources
Functional domains of the Xenopus replication licensing factor Cdt1 [PDF]
Nucleic Acids Research, 2005 During late mitosis and early G1, replication origins are licensed for subsequent replication by loading heterohexamers of the mini-chromosome maintenance proteins (Mcm2-7). To prevent re-replication of DNA, the licensing system is down-regulated at other cell cycle stages.
Ferenbach, Andrew +3 more
openaire +4 more sources
Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways [PDF]
Cell Division, 2007 In eukaryotes, DNA replication is strictly regulated so that it occurs only once per cell cycle. The mechanisms that prevent excessive DNA replication are focused on preventing replication origins from being reused within the same cell cycle.
Kim Youngjo, Kipreos Edward T
doaj +2 more sources
Structural insights into the Cdt1-mediated MCM2–7 chromatin loading [PDF]
Nucleic Acids Research, 2011 Initiation of DNA replication in eukaryotes is exquisitely regulated to ensure that DNA replication occurs exactly once in each cell division. A conserved and essential step for the initiation of eukaryotic DNA replication is the loading of the mini-chromosome maintenance 2-7 (MCM2-7) helicase onto chromatin at replication origins by Cdt1. To elucidate
Liu, Changdong LIFS +7 more
openaire +4 more sources