Results 31 to 40 of about 5,745 (188)

Mitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response. [PDF]

PLoS ONE, 2015
Cdt1 begins to accumulate in M phase and has a key role in establishing replication licensing at the end of mitosis or in early G1 phase. Treatments that damage the DNA of cells, such as UV irradiation, induce Cdt1 degradation through PCNA-dependent CRL4-
Masayuki Morino, Kohei Nukina, Hiroki Sakaguchi, Takeshi Maeda, Michiyo Takahara, Yasushi Shiomi, Hideo Nishitani   +6 more
doaj   +1 more source

The SCFSkp2 Ubiquitin Ligase Complex Interacts with the Human Replication Licensing Factor Cdt1 and Regulates Cdt1 Degradation [PDF]

Journal of Biological Chemistry, 2003
DNA replication initiation is tightly controlled so that each origin only fires once per cell cycle. Cell cycle-dependent Cdt1 degradation plays an essential role in DNA replication control, as overexpression of Cdt1 leads to re-replication. In this study, we investigated the mechanisms of Cdt1 degradation in mammalian cells.
Xianghong, Li, Qiping, Zhao, Rong, Liao, Peiqing, Sun, Xiaohua, Wu   +4 more
openaire   +2 more sources

Mouse Geminin Inhibits Not Only Cdt1-MCM6 Interactions but Also a Novel Intrinsic Cdt1 DNA Binding Activity [PDF]

Journal of Biological Chemistry, 2002
DNA replication is controlled by the stepwise assembly of a pre-replicative complex and the replication apparatus. Cdt1 is a novel component of the pre-replicative complex and plays a role in loading the minichromosome maintenance (MCM) 2-7 complex onto chromatin.
Ken-ichiro, Yanagi, Takeshi, Mizuno, Zhiying, You, Fumio, Hanaoka   +3 more
openaire   +2 more sources

SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis

Cancer Medicine, 2021
Background Cisplatin is an extensively used chemotherapy agent for lung cancer, but its drug resistance serves as a huge obstacle for chemotherapy failure of lung cancer patients.
Yang Cao, Ping Li, Haicun Wang, Lei Li, Quanwang Li   +4 more
doaj   +1 more source

A helicase-tethered ORC flip enables bidirectional helicase loading

eLife, 2021
Replication origins are licensed by loading two Mcm2-7 helicases around DNA in a head-to-head conformation poised to initiate bidirectional replication. This process requires origin–recognition complex (ORC), Cdc6, and Cdt1.
Shalini Gupta, Larry J Friedman, Jeff Gelles, Stephen P Bell   +3 more
doaj   +1 more source

DNA replication licensing in somatic and germ cells [PDF]

, 2004
The DNA replication (or origin) licensing system ensures precise duplication of the genome in each cell cycle and is a powerful regulator of cell proliferation in metazoa.
Williams, C, Jung, Hyo-Il, Obermann, EC, Ellen C. Obermann, Kai Stoeber, Loddo, Marco, Kathryn Leigh Eward, Marco Loddo, Shreeram, S, Williams, GH, Obermann, Ellen C, Hyo-Il Jung, Williams, Craig, J. Julian Blow, Gareth H. Williams, Eward, Kathryn Leigh, Fanshawe, Thomas, Jung, HI, Shreeram, S., Prevost, Toby; id_orcid, Blow, J. Julian; id_orcid, A. Toby Prevost, Loddo, M, Williams, Gareth H., Thomas Fanshawe, Fanshawe, T, Obermann, Ellen C., Eward, KL, Williams, Gareth H, Jung, H-I, S. Shreeram, Blow, J Julian, Prevost, A. Toby, Stoeber, K, Stoeber, Kai, Blow, J. Julian, Prevost, AT, Blow, JJ, Craig Williams   +38 more
core   +1 more source

Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation. [PDF]

PLoS ONE, 2012
The DNA replication-licensing factor Cdt1 is present during the G1 phase of the cell cycle. When cells initiate S phase or are UV-irradiated, Cdt1 is recruited to chromatin-bound PCNA and ubiquitinated by CRL4(Cdt2) for degradation.
Hiroki Sakaguchi, Toshihiro Takami, Yoshinori Yasutani, Takeshi Maeda, Masayuki Morino, Takashi Ishii, Yasushi Shiomi, Hideo Nishitani   +7 more
doaj   +1 more source

Intermittent hypoxia-induced downregulation of microRNA-320b promotes lung cancer tumorigenesis by increasing CDT1 via USP37

Molecular Therapy: Nucleic Acids, 2021
Obstructive sleep apnea-hypopnea (OSAH) is correlated with an increased incidence of lung cancer. In our study, we explored the functional roles of microRNAs (miRNAs) in lung cancer patients that were complicated with OSAH involving the deubiquitination ...
Weihao Li, Kai Huang, Fengbiao Wen, Guanghui Cui, Haizhou Guo, Zhanfeng He, Song Zhao   +6 more
doaj   +1 more source

Mismatch repair regulates Cdt1 after UV damage [PDF]

Cell Cycle, 2017
Mismatch repair (MMR) corrects mismatches in newly synthesized DNA strands.1 Key factors in the recognition of the mismatched bases are the Msh2 and Msh6 ATPases, which act during DNA replication a...
Andreas, Panagopoulos, Stavros, Taraviras, Zoi, Lygerou   +2 more
openaire   +2 more sources

The Distribution of Cytotoxic Necrotizing Factors (CNF-1, CNF-2, CNF-3) and Cytolethal Distending Toxins (CDT-1, CDT-2, CDT-3, CDT-4) in Escherichia coli Isolates Isolated from Extraintestinal Infections and the Determination of their Phylogenetic Relationship by PFGE

International Journal of Clinical Practice, 2022
Backgrounds. Diagnostic markers of extraintestinal infection in Escherichia coli (E. coli) remain unclear in the literature. Extraintestinal pathogenic E. coli (ExPEC) is differentiated from other E.
Cansu Onlen Guneri, Fatih Koksal, Suna Kizilyildirim, Basak Bedir, Togrul Nagiyev   +4 more
doaj   +1 more source