Results 31 to 40 of about 5,045 (159)
Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage [PDF]
Journal of Biological Chemistry, 2008 The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA replication initiation. Mechanisms to ensure that metazoan origins initiate once per cell cycle include degradation of Cdt1 during S phase and inhibition of Cdt1 by the geminin protein.
Jonathan R, Hall +6 more
openaire +2 more sources
Mismatch repair regulates Cdt1 after UV damage [PDF]
Cell Cycle, 2017 Mismatch repair (MMR) corrects mismatches in newly synthesized DNA strands.1 Key factors in the recognition of the mismatched bases are the Msh2 and Msh6 ATPases, which act during DNA replication a...
Andreas, Panagopoulos +2 more
openaire +2 more sources
International Journal of Clinical Practice, 2022 Backgrounds. Diagnostic markers of extraintestinal infection in Escherichia coli (E. coli) remain unclear in the literature. Extraintestinal pathogenic E. coli (ExPEC) is differentiated from other E.
Cansu Onlen Guneri +4 more
doaj +1 more source
Distinct and sequential re-replication barriers ensure precise genome duplication.
PLoS Genetics, 2020 Achieving complete and precise genome duplication requires that each genomic segment be replicated only once per cell division cycle. Protecting large eukaryotic genomes from re-replication requires an overlapping set of molecular mechanisms that prevent
Yizhuo Zhou +4 more
doaj +1 more source
DDB1 Maintains Genome Integrity through Regulation of Cdt1 [PDF]
Molecular and Cellular Biology, 2006 DDB1, a component of a Cul4A ubiquitin ligase complex, promotes nucleotide excision repair (NER) and regulates DNA replication. We have investigated the role of human DDB1 in maintaining genome stability. DDB1-depleted cells accumulate DNA double-strand breaks in widely dispersed regions throughout the genome and have activated ATM and ATR cell cycle ...
Courtney A, Lovejoy +3 more
openaire +2 more sources
MCM9 Binds Cdt1 and Is Required for the Assembly of Prereplication Complexes [PDF]
Molecular Cell, 2008 Prereplication complexes (pre-RCs) define potential origins of DNA replication and allow the recruitment of the replicative DNA helicase MCM2-7. Here, we characterize MCM9, a member of the MCM2-8 family. We demonstrate that MCM9 binds to chromatin in an ORC-dependent manner and is required for the recruitment of the MCM2-7 helicase onto chromatin.
Lutzmann, Malik, Méchali, Marcel
openaire +3 more sources
In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias
Cell Reports, 2017 Summary: Mammalian DNA replication origins are “licensed” by the loading of DNA helicases, a reaction that is mediated by CDC6 and CDT1 proteins. After initiation of DNA synthesis, CDC6 and CDT1 are inhibited to prevent origin reactivation and DNA ...
Sergio Muñoz +6 more
doaj +1 more source
Cell Division, 2006 In eukaryotic cells, replication of genomic DNA initiates from multiple replication origins distributed on multiple chromosomes. To ensure that each origin is activated precisely only once during each S phase, a system has evolved which features periodic
Fujita Masatoshi
doaj +1 more source
Scientific Reports, 2022 Recently, we reported that extent of proliferation of atypical hepatocytes (atypical hepatocytes) was most important histological risk factor for development of hepatocellular carcinoma (HCC) from chronic hepatitis C or liver cirrhosis. Here, we aimed to
Mitsuhiko Moriyama +16 more
doaj +1 more source
Geminin Stabilizes Cdt1 during Meiosis in Xenopus Oocytes [PDF]
Journal of Biological Chemistry, 2009 During the mitotic cell cycle, Geminin can act both as a promoter and inhibitor of initiation of DNA replication. As a promoter, Geminin stabilizes Cdt1 and facilitates its accumulation leading to the assembly of the pre-replication complex on DNA. As an inhibitor, Geminin prevents Cdt1 from loading the mini-chromosome maintenance complex onto pre ...
Yadushyla, Narasimhachar, Martine, Coué
openaire +2 more sources