Results 31 to 40 of about 6,157 (185)

SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis

Cancer Medicine, 2021
Background Cisplatin is an extensively used chemotherapy agent for lung cancer, but its drug resistance serves as a huge obstacle for chemotherapy failure of lung cancer patients.
Yang Cao, Ping Li, Haicun Wang, Lei Li, Quanwang Li   +4 more
doaj   +1 more source

A helicase-tethered ORC flip enables bidirectional helicase loading

eLife, 2021
Replication origins are licensed by loading two Mcm2-7 helicases around DNA in a head-to-head conformation poised to initiate bidirectional replication. This process requires origin–recognition complex (ORC), Cdc6, and Cdt1.
Shalini Gupta, Larry J Friedman, Jeff Gelles, Stephen P Bell   +3 more
doaj   +1 more source

Mismatch repair regulates Cdt1 after UV damage [PDF]

Cell Cycle, 2017
Mismatch repair (MMR) corrects mismatches in newly synthesized DNA strands.1 Key factors in the recognition of the mismatched bases are the Msh2 and Msh6 ATPases, which act during DNA replication a...
Andreas, Panagopoulos, Stavros, Taraviras, Zoi, Lygerou   +2 more
openaire   +2 more sources

DNA replication licensing in somatic and germ cells [PDF]

, 2004
The DNA replication (or origin) licensing system ensures precise duplication of the genome in each cell cycle and is a powerful regulator of cell proliferation in metazoa.
Williams, C, Jung, Hyo-Il, Obermann, EC, Ellen C. Obermann, Kai Stoeber, Loddo, Marco, Kathryn Leigh Eward, Marco Loddo, Shreeram, S, Williams, GH, Obermann, Ellen C, Hyo-Il Jung, Williams, Craig, J. Julian Blow, Gareth H. Williams, Eward, Kathryn Leigh, Fanshawe, Thomas, Jung, HI, Shreeram, S., Prevost, Toby; id_orcid, Blow, J. Julian; id_orcid, A. Toby Prevost, Loddo, M, Williams, Gareth H., Thomas Fanshawe, Fanshawe, T, Obermann, Ellen C., Eward, KL, Williams, Gareth H, Jung, H-I, S. Shreeram, Blow, J Julian, Prevost, A. Toby, Stoeber, K, Stoeber, Kai, Blow, J. Julian, Prevost, AT, Blow, JJ, Craig Williams   +38 more
core   +1 more source

Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation. [PDF]

PLoS ONE, 2012
The DNA replication-licensing factor Cdt1 is present during the G1 phase of the cell cycle. When cells initiate S phase or are UV-irradiated, Cdt1 is recruited to chromatin-bound PCNA and ubiquitinated by CRL4(Cdt2) for degradation.
Hiroki Sakaguchi, Toshihiro Takami, Yoshinori Yasutani, Takeshi Maeda, Masayuki Morino, Takashi Ishii, Yasushi Shiomi, Hideo Nishitani   +7 more
doaj   +1 more source

Intermittent hypoxia-induced downregulation of microRNA-320b promotes lung cancer tumorigenesis by increasing CDT1 via USP37

Molecular Therapy: Nucleic Acids, 2021
Obstructive sleep apnea-hypopnea (OSAH) is correlated with an increased incidence of lung cancer. In our study, we explored the functional roles of microRNAs (miRNAs) in lung cancer patients that were complicated with OSAH involving the deubiquitination ...
Weihao Li, Kai Huang, Fengbiao Wen, Guanghui Cui, Haizhou Guo, Zhanfeng He, Song Zhao   +6 more
doaj   +1 more source

DDB1 Maintains Genome Integrity through Regulation of Cdt1 [PDF]

Molecular and Cellular Biology, 2006
DDB1, a component of a Cul4A ubiquitin ligase complex, promotes nucleotide excision repair (NER) and regulates DNA replication. We have investigated the role of human DDB1 in maintaining genome stability. DDB1-depleted cells accumulate DNA double-strand breaks in widely dispersed regions throughout the genome and have activated ATM and ATR cell cycle ...
Courtney A, Lovejoy, Kimberli, Lock, Ashwini, Yenamandra, David, Cortez   +3 more
openaire   +2 more sources

The Distribution of Cytotoxic Necrotizing Factors (CNF-1, CNF-2, CNF-3) and Cytolethal Distending Toxins (CDT-1, CDT-2, CDT-3, CDT-4) in Escherichia coli Isolates Isolated from Extraintestinal Infections and the Determination of their Phylogenetic Relationship by PFGE

International Journal of Clinical Practice, 2022
Backgrounds. Diagnostic markers of extraintestinal infection in Escherichia coli (E. coli) remain unclear in the literature. Extraintestinal pathogenic E. coli (ExPEC) is differentiated from other E.
Cansu Onlen Guneri, Fatih Koksal, Suna Kizilyildirim, Basak Bedir, Togrul Nagiyev   +4 more
doaj   +1 more source

Distinct and sequential re-replication barriers ensure precise genome duplication.

PLoS Genetics, 2020
Achieving complete and precise genome duplication requires that each genomic segment be replicated only once per cell division cycle. Protecting large eukaryotic genomes from re-replication requires an overlapping set of molecular mechanisms that prevent
Yizhuo Zhou, Pedro N Pozo, Seeun Oh, Haley M Stone, Jeanette Gowen Cook   +4 more
doaj   +1 more source

Geminin Stabilizes Cdt1 during Meiosis in Xenopus Oocytes [PDF]

Journal of Biological Chemistry, 2009
During the mitotic cell cycle, Geminin can act both as a promoter and inhibitor of initiation of DNA replication. As a promoter, Geminin stabilizes Cdt1 and facilitates its accumulation leading to the assembly of the pre-replication complex on DNA. As an inhibitor, Geminin prevents Cdt1 from loading the mini-chromosome maintenance complex onto pre ...
Yadushyla, Narasimhachar, Martine, Coué
openaire   +2 more sources