Results 1 to 10 of about 44,476 (276)

Intraoperative Redosing of Cefazolin and Risk for Surgical Site Infection in Cardiac Surgery [PDF]

Emerging Infectious Diseases, 2001
Intraoperative redosing of prophylactic antibiotics is recommended for prolonged surgical procedures, although its efficacy has not been assessed. We retrospectively compared the risk of surgical site infections in 1,548 patients who underwent cardiac ...
Giorgio Zanetti, Richard Giardina, Richard Platt   +2 more
doaj   +7 more sources

Caveats of Metronidazole Addition for Surgical Site Infection Prophylaxis in Gynecologic Surgeries [PDF]

Pharmacology Research & Perspectives
Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
Minh‐Hoang Tran, Kim‐Huong Truong‐Nguyen   +1 more
doaj   +3 more sources

Clinical pharmacology of cefazolin

Advances in Biomedical and Health Sciences, 2022
Cefazolin is a first-generation cephalosporin that is active against gram-positive bacteria and has modest activity against gram-negative organisms, and cefazolin is excreted by glomerular filtration.
Gian Maria Pacifici
doaj   +2 more sources

Effect of Inadequate Treatment in Adult Patients with Community-Acquired Acute Pyelonephritis Due to Enterobacterales Under Empirical Management with Cefazolin [PDF]

Antibiotics
Background/Objectives: First-generation cephalosporins are used in some countries, primarily in Latin America and other low-resource regions, as a first-line or alternative empirical treatment for patients with acute pyelonephritis (AP). This study aimed
Laura Cristina Nocua-Báez, Patricia Reyes, Jorge Alberto Cortes   +2 more
doaj   +2 more sources

Cefazolin Alone Versus Cefazolin With Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Total Joint Arthroplasty [PDF]

Arthroplasty Today
Background: Prosthetic joint infection is a serious complication of total knee arthroplasty (TKA) and total hip arthroplasty (THA). While cefazolin is the standard prophylactic antibiotic, some groups have considered adding aminoglycosides (gentamycin or
Meera M. Dhodapkar, MD, MHS, Scott J. Halperin, MD, MHS, Zachary Radford, MD, Lee E. Rubin, MD, FAAOS, FAOA, Jonathan N. Grauer, MD, Mengnai Li, FAAOS, MD, PhD   +5 more
doaj   +2 more sources

Cefazolin inoculum effect among methicillinsusceptible Staphylococcus aureus isolated from patients with skin infections [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2021
Objective. To evaluate frequency and intensity of cefazolin inoculum effect among methicillin-susceptible staphylococci isolated from patients with skin infections. Materials and Methods.
Vaganova А.N., Borisenko S.V., Nesterova E.V., Trofimova N.N., Litvinenko I.V., Petunova Y.G., Roca W.V., Verbov V.N.   +7 more
doaj   +1 more source

Overproduction of Chromosomal ampC β-Lactamase Gene Maintains Resistance to Cefazolin in Escherichia coli Isolates

Microbiology Spectrum, 2022
Cefazolin, an active in vitro agent against Escherichia coli, is used to treat urinary and biliary tract infections. Cefazolin is used widely as an antibiotic, and the increase in the emergence of cefazolin-resistant E.
Masato Kawamura, Ryota Ito, Yurina Tamura, Mio Takahashi, Miho Umenai, Yuriko Chiba, Takumi Sato, Shigeru Fujimura   +7 more
doaj   +1 more source

Safety of Cefazolin in Prophylaxis in Β-Lactam Allergic Children

Bezmiâlem Science, 2022
Objective:Cefazolin is a first-generation cephalosporin, particularly effective against gram positive agents such as staphylococci and streptococci. Despite this narrow spectrum, it is important in surgical prophylaxis.
Ayşe SÜLEYMAN, Esra YÜCEL, Zeynep TAMAY, Nermin GÜLER   +3 more
doaj   +1 more source

Population pharmacokinetic model of cefazolin in total hip arthroplasty

Scientific Reports, 2021
Cefazolin is an antibiotic recommended for infection prevention in total hip arthroplasty (THA). However, the dosing regimen necessary to achieve therapeutic concentrations in obese patients remains unclear.
J. Lanoiselée, R. Chaux, S. Hodin, S. Bourayou, A. Gibert, R. Philippot, S. Molliex, P. J. Zufferey, X. Delavenne, E. Ollier   +9 more
doaj   +1 more source

Increased Rate of Early Periprosthetic Joint Infection in Total Hip Arthroplasty With the Use of Alternatives to Cefazolin Despite Additional Gram-Negative Coverage

Arthroplasty Today, 2022
Background: Periprosthetic joint infection (PJI) remains one of the most devastating complications following total joint arthroplasty. Appropriate prophylactic antimicrobial administration and antibiotic stewardship are major factors impacting the risk ...
Dionisio Ortiz, III, MD, Greg M. Teo, MD, Katherine Lygrisse, MD, Vinay K. Aggarwal, MD, William J. Long, MD, FRCSC   +4 more
doaj   +1 more source