Results 91 to 100 of about 3,471,294 (187)
Annals of Clinical Microbiology and AntimicrobialsAbstract Background During prolonged FDC therapy, the emergence of FDC non-susceptibility in CRAB has been reported. Here, we report a transmission cluster of FDC-non-susceptible CRAB in four patients, all naïve to FDC treatment, characterized by a premature stop codon and amino acid deletion in the PirA protein.
Alteri, Claudia +16 more
openaire +3 more sources
An NDM-Producing Escherichia coli Clinical Isolate Exhibiting Resistance to Cefiderocol and the Combination of Ceftazidime-Avibactam and Aztreonam: Another Step Toward Pan-β-Lactam Resistance [PDF]
, 2023 Patricia J. Simner +6 more
openalex +1 more source
Antibiotics, 2022 Multidrug resistant Gram-negative bacteremia represents a therapeutic challenge clinicians have to deal with. This concern becomes more difficult when causing germs are represented by carbapenem resistant Acinetobacter baumannii or difficult-to-treat ...
Andrea Marino +8 more
doaj +1 more source
Treatment of carbapenem-resistantPseudomonas aeruginosainfections: a case for cefiderocol
Expert Review of Anti-infective Therapy, 2022 Carbapenem-resistant (CR) Pseudomonas aeruginosa infections constitute a serious clinical threat globally. Patients are often critically ill and/or immunocompromised. Antibiotic options are limited and are currently centered on beta-lactam-beta-lactamase inhibitor (BL-BLI) combinations and the siderophore cephalosporin cefiderocol.This article reviews ...
Rafael, Canton +2 more
openaire +2 more sources
FEBS Open Bio, Volume 16, Issue 4, Page 751-765, April 2026.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
Journal of Global Antimicrobial Resistance, 2021 : Objectives: : Antimicrobial resistance, particularly carbapenem resistance, in Gram-negative pathogens poses a significant healthcare threat. Carbapenem resistance rates in Italy are among the highest in Europe.
Stefano Stracquadanio +4 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT S. maltophilia is a multidrug‐resistant nosocomial pathogen that poses significant challenges in CKD patients. Antibiotic selection in CKD is complicated by nephrotoxicity concerns and limited clinical data. Combination therapy and novel agents like cefiderocol and CZA‐ATM are emerging alternatives but require further validation.
Joydip Chowdhury +4 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background and Aims Pneumonia is an inflammatory condition of the lower respiratory tract, commonly caused by infection and associated with substantial morbidity and healthcare utilization. The burden of pneumonia on healthcare is exacerbated by limited data on pathogenic causes and associated antimicrobial resistance (AMR). Here, we conducted
Radmir Sarsenov +7 more
wiley +1 more source
Cefiderocol Retains Antibiofilm Activity in Multidrug-Resistant Gram-Negative Pathogens
Antimicrobial Agents and Chemotherapy, 2021 Cefiderocol is a siderophore cephalosporin with potent antibacterial activity against a broad range of Gram-negative pathogens, including multidrug-resistant strains. Siderophore antibiotics bind ferric iron and utilize iron transporters to cross the cell membrane.
Pybus, Christine A. +3 more
openaire +2 more sources
In vitro activity of cefiderocol against nosocomial Acinetobacter baumannii
Microbiology SpectrumThe emergence and spread of third-/fourth-generation cephalosporin and/or carbapenem-resistant Acinetobacter baumannii have become a significant global public health concern, making new treatment alternatives necessary.
Barbara Ymaña +20 more
doaj +1 more source