Results 101 to 110 of about 3,471,294 (187)

A Survey of the Microbiome, Culturome and ARG Profile of a Cohort of Chronic Diabetic Foot Lesions

APMIS, Volume 134, Issue 4, April 2026.
ABSTRACT This study aimed to analyse the microbiome of chronic infected diabetic foot ulcers (DFUs) using parallel methods: traditional culture (the culturome), 16S rRNA gene sequencing (the microbiome) as well as the Antibiotic Resistance Gene (ARG) profile of isolated strains. Swab samples were collected in parallel from affected ulcers.
Karolina I. Pyrzanowska, Elspeth N. Smith, Chandra Ramalingam, Marni Greig, Rajiv A. Gandhi, Susan Heyes, Debora Sanger, Tracy Smith, David G. Partridge, Graham P. Stafford   +9 more
wiley   +1 more source

Cefiderocol: a promising antibiotic against multidrug-resistant Gram-negative bacteria [PDF]

Expert Review of Anti-infective Therapy, 2019
Spread of drug-resistant Gram-negative bacteria (GNB), including carbapenem-resistant (CR)-Pseudomonas aeruginosa, CR-Acinetobacter baumannii, and particularly the third-generation cephalosporin- a...
Shio-Shin, Jean, Shun-Chung, Hsueh, Wen-Sen, Lee, Po-Ren, Hsueh   +3 more
openaire   +2 more sources

Exploiting Pharmacokinetic/Pharmacodynamic Methods for Optimizing and Accelerating Drug Development of Innovative Anti‐Infectives

ChemMedChem, Volume 21, Issue 2, January 2026.
This article focuses on the interplay of absorbed, distributed, metabolized, and excreted (ADME) properties; in vivo pharmacokinetics (PK); and pharmacodynamics (PD) supported by in silico PK/PD modeling techniques to improve drug development by acceleration of processes and reducing attrition risks.
Katharina Rox
wiley   +1 more source

Recurrence of Postneurosurgical Central Nervous System Infection Caused by Acinetobacter baumannii in a Critically Ill Patient Treated With Cefiderocol. A Case Report

Case Reports in Infectious Diseases, Volume 2026, Issue 1, 2026.
Introduction Acinetobacter baumannii (A. baumannii), a gram‐negative bacterium, has become a significant hospital pathogen and the cause of severe nosocomial infections, especially in the intensive care unit (ICU). Bacterial meningitis is a recognized complication that can occur after neurosurgery, and the number of cases of multidrug‐resistant (MDR ...
Giuseppe Accurso, Angelica Ancona, Giovanni Marco Costa, Filippo Vitale, Domenico Petronaci, Giorgia Corpora, Luigi Profera, Antonino Giarratano, Santi Maurizio Raineri, Priya Gusain   +9 more
wiley   +1 more source

A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi, Swaran J. S. Flora   +9 more
wiley   +1 more source

Determinants of Antimicrobial Resistance in Acinetobacter baumannii Isolates From Intensive Care Patients in Latvia

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Background Acinetobacter baumannii is a leading nosocomial pathogen in intensive care units (ICUs), often resistant to multiple antibiotics. Data from the Baltic region remain scarce, limiting infection control and stewardship strategies. Methods We conducted an integrated phenotypic–genotypic analysis of A.
Mihails Dolgusevs, Nityanand Jain, Oksana Savicka, Reinis Vangravs, Jevgenijs Bodrenko, Liene Ostele-Cešķe, Gustavs Rindžs, Dace Zemite, Aigars Reinis, Baiba Rozentale, Divakar Sharma   +10 more
wiley   +1 more source

Frequency of cefiderocol heteroresistance among patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections

JAC-Antimicrobial Resistance
Abstract Background Cefiderocol exhibits potent in vitro activity against carbapenem-resistant Acinetobacter baumannii (CRAb), but this activity has not consistently translated to improved outcomes among patients.
Ryan K Shields, Ava J Dorazio, Giusy Tiseo, Kevin M Squires, Alessandro Leonildi, Cesira Giordano, Ellen G Kline, Simona Barnini, Alina Iovleva, Marissa P Griffith, Daria Van Tyne, Yohei Doi, Marco Falcone   +12 more
openaire   +3 more sources

Challenges Facing Two Outbreaks of Carbapenem-Resistant Acinetobacter baumannii: From Cefiderocol Susceptibility Testing to the Emergence of Cefiderocol-Resistant Mutants

Antibiotics
Carbapenem-resistant Acinetobacter baumannii (CRAB) infections are associated with poor outcomes depending on patient’s conditions, clinical severity and type of infection, and treatment is challenging given the limited therapeutic options available. The aim of this study was to describe the clinical and microbiological characteristics of two outbreaks
Montserrat Rodríguez-Aguirregabiria, Fernando Lázaro-Perona, Juana Begoña Cacho-Calvo, Mª Soledad Arellano-Serrano, Juan Carlos Ramos-Ramos, Eduardo Rubio-Mora, Mariana Díaz-Almirón, Mª José Asensio-Martín   +7 more
openaire   +5 more sources

Biosynthesis of H2S and Siderophores Targeting Gram‐Negative Bacterial Resistance to Reactive Oxygen Species

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Discover how Gram‐negative bacteria develop resistance to reactive oxygen species, and how scientists aim to overcome this challenge. Abstract Reactive oxygen species (ROS) are a promising alternative bactericide. However, it is questioned that bacteria can potentially develop resistance to ROS, similar to their resistance against antibiotics and ...
Congyang Mao, Wanyu Jin, Yiming Xiang, Yizhou Zhu, Jun Wu, Xiangmei Liu, Shuilin Wu, Wei Qiao, Kenneth M. C. Cheung, Kelvin Wai Kwok Yeung   +9 more
wiley   +1 more source

Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy
ABSTRACT We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM ...
Kaan Kocer, Truong Nhat My, Bui Tien Sy, Lisa Göpel, Thirumalaisamy P. Velavan, Le Huu Song, Silke Peter, Sébastien Boutin, Adesola Olalekan, Dennis Nurjadi   +9 more
openaire   +3 more sources