Results 121 to 130 of about 3,471,294 (187)

In vitro activity of cefiderocol against Pseudomonas aeruginosa demonstrating evolved resistance to novel β-lactam/β-lactamase inhibitors [PDF]

, 2023
Ryan K. Shields, Ellen G Kline, Kevin M Squires, Daria Van Tyne, Yohei Doi   +4 more
openalex   +1 more source

A Val292 substitution combined with an alanine duplication (ADUP) in the Ω loop of ADC β-lactamase confers reduced susceptibility to advanced β-lactam agents, including cefiderocol

mBio
Intrinsic Acinetobacter-derived cephalosporinases (ADCs) in Acinetobacter baumannii are AmpC-type β-lactamases that confer resistance to β-lactam agents, typically through insertion sequence (IS) element-driven overexpression.
Akito Kawai, Christi L. McElheny, Ryan K. Shields, Cesar A. Arias, David L. Paterson, Robin Patel, Robert A. Bonomo, Vance G. Fowler, David van Duin, Yohei Doi   +9 more
doaj   +1 more source

Hetero-antagonism of avibactam and sulbactam with cefiderocol in carbapenem-resistant Acinetobacter spp.

Microbiology Spectrum
Cefiderocol, a siderophore-cephalosporine conjugate antibiotic, shows promise as a therapeutic option for carbapenem-resistant (CR) Acinetobacter infections. While resistance has already been reported in A. baumannii, combination therapies with avibactam
Olivia Wong, Vyanka Mezcord, Christina Lopez, German Matias Traglia, Fernando Pasteran, Marisel R. Tuttobene, Alejandra Corso, Marcelo E. Tolmasky, Robert A. Bonomo, María Soledad Ramirez   +9 more
doaj   +1 more source

In vitro activity of ceftazidime/avibactam, cefiderocol, meropenem/vaborbactam and imipenem/relebactam against clinical strains of the Stenotrophomonas maltophilia complex.

PLoS ONE
BackgroundInfections caused by Stenotrophomonas maltophilia and related species are increasing worldwide. Unfortunately, treatment options are limited, whereas the antimicrobial resistance is increasing.MethodsWe included clinical isolates identified as ...
Braulio Josué Méndez-Sotelo, Mónica Delgado-Beltrán, Melissa Hernández-Durán, Claudia Adriana Colín-Castro, José Esquivel-Bautista, Sandra Angélica Ortega-Oliva, Jossue Ortiz-Álvarez, Rodolfo García-Contreras, Rafael Franco-Cendejas, Luis Esau Lopez Jacome   +9 more
doaj   +1 more source

Cefiderocol Comparative Resistance and Clinical Predictors in CRE-BSI: Data from an OXA-48–Endemic Region with Rising OXA-48/NDM Coproducers

Antibiotics
Background/Objectives: Bloodstream infections (BSIs) caused by carbapenem-resistant Enterobacterales (CREs) are a growing public health threat due to limited therapeutic options and high mortality.
Rıdvan Dumlu, Ali Mert
doaj   +1 more source

Cefiderocol susceptibility of Achromobacter spp.: study of an accurately identified collection of 230 strains

Annals of Clinical Microbiology and Antimicrobials
Background Achromobacter spp. are opportunistic pathogens, mostly infecting immunocompromised patients and patients with cystic fibrosis (CF) and considered as difficult-to-treat pathogens due to both intrinsic resistance and the possibility of acquired ...
Vincent Jean-Pierre, Pauline Sorlin, Alix Pantel, Raphaël Chiron, Jean-Philippe Lavigne, Katy Jeannot, Hélène Marchandin, Collaborative study group on antimicrobial resistance of Achromobacter spp.   +7 more
doaj   +1 more source

Clonal lineage and biofilm growth shape cefiderocol activity in Acinetobacter baumannii from oncology patients

Frontiers in Cellular and Infection Microbiology
IntroductionAcinetobacter baumannii is a leading cause of healthcare-associated infections in immunocompromised patients and frequently exhibits multidrug resistance.
Ilaria Cavallo, Francesca Sivori, Mauro Truglio, Massimo Francalancia, Elva Abril, Giorgia Fabrizio, Sara Petrolo, Francesca Maione, Grazia Prignano, Arianna Mastrofrancesco, Fulvia Pimpinelli, Enea Gino Di Domenico   +11 more
doaj   +1 more source

In vitro activity of cefiderocol against Gram-negative aerobic bacilli in planktonic and biofilm form–alone and in combination with bacteriophages

Scientific Reports
Multi-drug resistant Gram-negative pathogens are increasingly difficult-to-treat perpetrators of infections. New, innovative, and more multifaceted therapies for the treatment of multi-drug resistant strains are thus urgent to hinder further drug ...
Rima Fanaei Pirlar, Nexhmije Halili, Tina Travnik, Andrej Trampuz, Svetlana Karbysheva   +4 more
doaj   +1 more source

P37 Molecular characterization of resistance and heteroresistance to cefiderocol in clinical Gram-negative isolates [PDF]

Francesca Young, C.D. Watson, Sylvia Rofael, Emmanuel Wey, Indran Balakrishnan   +4 more
openalex   +1 more source

A New Hope Against Antimicrobial-Resistance Wars: Cefiderocol

The increasing diffusion of antimicrobial resistance represents one of the major public health problems worldwide. In the last years, novel antimicrobial molecules have been developed to contrast the emergence of antimicrobial resistance and to provide a valuable therapeutic options against multi drug-resistant (MDR) GNB microorganisms.
Gabriele Bianco, Matteo Boattini, Monica Cricca, Lucia Diella, Milo Gatti, Luca Rossi, Michele Bartoletti, Vittorio Sambri, Davide Gibellini, Rossella Fonnesu, Sara Comini, Paolo Gaibani   +11 more
openaire   +1 more source